3-Methylpiperidine-2,6-dione
- CAS No.
- 29553-51-3
- Chemical Name:
- 3-Methylpiperidine-2,6-dione
- Synonyms
- 3-Methyl-2,6-piperidinedione;3-Methylpiperidine-2,6-dione;2,6-Dioxo-3-methyl-piperazine;2,6-Piperidinedione, 3-methyl-
- CBNumber:
- CB62549486
- Molecular Formula:
- C6H9NO2
- Molecular Weight:
- 127.14
- MDL Number:
- MFCD13178824
- MOL File:
- 29553-51-3.mol
- MSDS File:
- SDS
3-Methylpiperidine-2,6-dione price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | EBA55351 | 3-Methylpiperidine-2,6-dione | 29553-51-3 | 0.5g | $300.9 | 2026-06-04 | Buy |
| Biosynth | EBA55351 | 3-Methylpiperidine-2,6-dione | 29553-51-3 | 5g | $885 | 2026-06-04 | Buy |
| Matrix Scientific | 310524 | 3-Methylpiperidine-2,6-dione | 29553-51-3 | 250.00mg | $78 | 2026-05-19 | Buy |
| Matrix Scientific | 310524 | 3-Methylpiperidine-2,6-dione | 29553-51-3 | 1.00g | $200 | 2026-05-19 | Buy |
| Synthonix | M43382 | 3-Methylpiperidine-2,6-dione 97% | 29553-51-3 | 100mg | $250 | 2026-05-06 | Buy |
3-Methylpiperidine-2,6-dione Chemical Properties,Uses,Production
Synthesis
18069-17-5
29553-51-3
Preparative Example 23: Synthesis of 3-methylpiperidine-2,6-dione Acetic anhydride (appropriate amount) was added to commercially available 2-methylglutaric acid (1 g, 6.8 mmol) at room temperature, and the mixture was refluxed and stirred at 60°C for 8 hours. After confirming the completion of the reaction by thin layer chromatography (TLC), the remaining acetic anhydride was removed under reduced pressure. The concentrated compound was dissolved in tetrahydrofuran (THF) and aqueous ammonia solution (1.7 mL, 14.6 mmol) was slowly added at 0 °C, followed by stirring for 8 h at room temperature. Upon completion of the reaction, the remaining ammonia solution was removed under reduced pressure, acetic anhydride was added, and then refluxed at 60 °C for 8 hours. The residual acetic anhydride was removed under reduced pressure. The concentrate was purified by column chromatography (eluent: ethyl acetate/hexane=1:1) to afford 682 mg (yield: 78%) of 3-methylpiperidine-2,6-dione. 1H NMR (400 MHz, MeOH-d4) δ 1.24-1.28 (m, 3H), 1.71-1.77 (m, 1H), 2.04-2.08 (m, 1H), 2.57-2.65 (m, 3H); MS (m/z) 128 (M+1).
References
[1] Patent: WO2009/82134, 2009, A2. Location in patent: Page/Page column 84-85
[2] Journal of the American Chemical Society, 1943, vol. 65, p. 270
[3] Bulletin de l'Academie Polonaise des Sciences, Serie des Sciences Chimiques, 1981, vol. 29, # 1-2, p. 11 - 16
[4] Journal of the American Chemical Society, 1982, vol. 104, # 25, p. 7257 - 7267
3-Methylpiperidine-2,6-dione Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
3-Methylpiperidine-2,6-dione Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
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| Shanghai Zhen Li Biological Technology Co., Ltd | 021-16621358918; 18516310516;16621358918;13045646768 | zhenlipharma888@163.com | China | 19060 | 58 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| Wuhan FengyaoTonghui Chemical Products Co., Ltd. | 027-87466105 15377573527 | 2678564200@qq.com | China | 17968 | 58 |
| Jinan Kabotang Biological Technology Co.,Ltd. | 0531-61320525 15866703830 | figo.gao@foxmail.com | China | 7601 | 58 |
| Suzhou Rovathin Foreign Trade Co.,Ltd | 0512-65816829 18662214788 | info@rovathin.com.cn | China | 9965 | 58 |
