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16(R)-AFP 07 (free acid)

16(R)-AFP 07 (free acid) Structure
16(R)-AFP 07 (free acid) structure
CAS No.
773825-80-2
Chemical Name:
16(R)-AFP 07 (free acid)
Synonyms
16(R)-AFP 07;16(R)-AFP 07 (free acid);PVHIRYQSPDZLLG-HWMGRDFZSA-N;Pentanoic acid, 5-[(3aR,4R,5R,6aS)-3,3-difluorohexahydro-5-hydroxy-4-[(1E,3R,4S)-3-hydroxy-4-methyl-1-nonen-6-ynyl]-2H-cyclopenta[b]furan-2-ylidene]-, (5Z)- (9CI);(5Z)-5-[(3aR,4R,5R,6aS)-3,3-difluoro-5-hydroxy-4-[(E,3R,4S)-3-hydroxy-4-methylnon-1-en-6-ynyl]-4,5,6,6a-tetrahydro-3aH-cyclopenta[b]furan-2-ylidene]pentanoic acid
CBNumber:
CB62589923
Molecular Formula:
C22H30F2O5
Molecular Weight:
412.47
MDL Number:
MOL File:
773825-80-2.mol
MSDS File:
SDS
Last updated:2026-05-28 04:13:10
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16(R)-AFP 07 (free acid) Properties

Boiling point 557.8±50.0 °C(Predicted)
Density 1.24±0.1 g/cm3(Predicted)
solubility DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 1 mg/ml
pka 4.70±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319-H336
Precautionary statements  P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
NFPA 704
3
2 0

16(R)-AFP 07 (free acid) price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10991 16(R)-AFP 07 (free acid) ≥98% 773825-80-2 500μg $303 2026-04-30 Buy
Cayman Chemical 10991 16(R)-AFP 07 (free acid) ≥98% 773825-80-2 1mg $574 2026-04-30 Buy
Cayman Chemical 10991 16(R)-AFP 07 (free acid) ≥98% 773825-80-2 5mg $2401 2026-04-30 Buy
AK Scientific 7006EC (5E)-5-[(3Ar,4R,5R,6aS)-3,3-difluoro-5-hydroxy-4-[(E,3S,4R)-3-hydroxy-4-methylnon-1-en-6-ynyl]-4,5,6,6a-tetrahydro-3aH-cyclopenta[b]furan-2-ylidene]pentanoicacid 773825-80-2 1mg $677 2021-12-16 Buy
Product number Packaging Price Buy
10991 500μg $303 Buy
10991 1mg $574 Buy
10991 5mg $2401 Buy
7006EC 1mg $677 Buy

16(R)-AFP 07 (free acid) Chemical Properties, Uses, Production

Description

Prostaglandin I2 is an unstable prostanoid which, through the ‘I prostanoid’ (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki = 0.561 nM).1 AFP 07 shows weaker affinity for EP receptors, with Ki values > 100 nM for EP1-3 and > 10 nM for EP4.1,2 16(R)-AFP 07 is an epimer of AFP 07. Its biological properties, particularly through the IP and EP receptors, remain to be evaluated.

Uses

Prostaglandin I2 is an unstable prostanoid which, through the ‘I prostanoid’ (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki=0.561 nM).1 AFP 07 shows weaker affinity for EP receptors, with Ki values > 100 nM for EP1-3 and > 10 nM for EP4. 16(R)-AFP 07 is an epimer of AFP 07. Its biological properties, particularly through the IP and EP receptors, remain to be evaluated.

References

1. Chang, C.s., Negishi, M., Nakano, T., et al. 7,7-Difluoroprostacyclin derivative, AFP-07, a highly selective and potent agonist for the prostacyclin receptor Prostaglandins 53(2),83-90(1997).
2. Jones, R.L., and Chan, K. Distinction between relaxations induced via prostanoid EP4 and IP1 receptors in pig and rabbit blood vessels Br. J. Pharmacol. 134(2),313-324(2001).

16(R)-AFP 07 (free acid) Preparation Products And Raw materials

Raw materials

Preparation Products

16(R)-AFP 07 (free acid) Suppliers

Global Suppliers ( 17)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8137 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
TargetMol 400-821-0310 15002144251 xuexiang.shao@tsbiochem.com China 29128 58
Supplier Advantage
BOC Sciences 65
Shanghai Hongye Biotechnology Co. Ltd 58
BOC Sciences 58
MedBioPharmaceutical Technology Inc 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol 58

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16(R)-AFP 07 (free acid) PVHIRYQSPDZLLG-HWMGRDFZSA-N 16(R)-AFP 07 (5Z)-5-[(3aR,4R,5R,6aS)-3,3-difluoro-5-hydroxy-4-[(E,3R,4S)-3-hydroxy-4-methylnon-1-en-6-ynyl]-4,5,6,6a-tetrahydro-3aH-cyclopenta[b]furan-2-ylidene]pentanoic acid Pentanoic acid, 5-[(3aR,4R,5R,6aS)-3,3-difluorohexahydro-5-hydroxy-4-[(1E,3R,4S)-3-hydroxy-4-methyl-1-nonen-6-ynyl]-2H-cyclopenta[b]furan-2-ylidene]-, (5Z)- (9CI) 773825-80-2 773525-80-2 C22H30F2O5