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(+/-)-15-Deoxy-16r-hydroxy-17-cyclobutyl prostaglandin E1

CAS No.
433219-55-7
Chemical Name:
(+/-)-15-Deoxy-16r-hydroxy-17-cyclobutyl prostaglandin E1
Synonyms
BUTAPROST (FREE ACID);(R)-BUTAPROST (FREE ACID);(S)-Butaprost (free acid);PAYNQYXOKJDXAV-ZHIWTBQHSA-N;(+/-)-15-Deoxy-16r-hydroxy-17-cyclobutyl prostaglandin E1;(+/-)-15-DEOXY-16S-HYDROXY-17-CYCLOBUTYL PROSTAGLANDIN E1;9-OXO-11ALPHA, 16R-DIHYDROXY-17-CYCLOBUTYL-PROST-13E-EN-1-OIC ACID;9-OXO-11ALPHA, 16S-DIHYDROXY-17-CYCLOBUTYL-PROST-13E-EN-1-OIC ACID;Cyclopentaneheptanoic acid, 3-hydroxy-2-[(1E,4S)-4-hydroxy-4-(1-propylcyclobutyl)-1-buten-1-yl]-5-oxo-, (1R,2R,3R)-
CBNumber:
CB6711207
Molecular Formula:
C23H38O5
Molecular Weight:
394.54
MDL Number:
MFCD05863943
MOL File:
433219-55-7.mol
MSDS File:
SDS
Last updated:2026-09-12 18:54:22

(+/-)-15-Deoxy-16r-hydroxy-17-cyclobutyl prostaglandin E1 Properties

storage temp. Store at -20°C
solubility DMF: 25 mg/ml; DMSO: 25/mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 100 μg/ml

SAFETY

Risk and Safety Statements

(+/-)-15-Deoxy-16r-hydroxy-17-cyclobutyl prostaglandin E1 price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13741 Butaprost (free acid) ≥95% 433219-55-7 500μg $120 2026-04-30 Buy
Cayman Chemical 13741 Butaprost (free acid) ≥95% 433219-55-7 1mg $228 2026-04-30 Buy
Cayman Chemical 13741 Butaprost (free acid) ≥95% 433219-55-7 5mg $960 2026-04-30 Buy
Cayman Chemical 13741 Butaprost (free acid) ≥95% 433219-55-7 10mg $1559 2026-04-30 Buy
ChemScene CS-0106575 (S)-Butaprost free acid 433219-55-7 1mg $788 2026-06-04 Buy
Product number Packaging Price Buy
13741 500μg $120 Buy
13741 1mg $228 Buy
13741 5mg $960 Buy
13741 10mg $1559 Buy
CS-0106575 1mg $788 Buy

(+/-)-15-Deoxy-16r-hydroxy-17-cyclobutyl prostaglandin E1 Chemical Properties, Uses, Production

Description

Butaprost is an EP2 selective agonist which has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells.1,2 Prostaglandin free acids generally bind to their cognate receptors with 10 to 100 times the affinity of the corresponding ester derivative. Consistent with this trend, butaprost binds to membranes from EP2 receptor-transfected CHO cells with a Ki value of 2,400 nM, whereas butaprost (free acid) and CAY10399 (the 2-series congener of butaprost free acid) exhibit significantly lower Ki values of 73 and 92 nM, respectively.3 Butaprost (free acid) is therefore another useful tool for characterizing EP receptor-mediated signalling events.

Uses

(S)-Butaprost (free acid) is a potent and highly selective agonist of EP2 receptor[1].

References

1. Kiriyama, M., Ushikubi, F., Kobayashi, T., et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells Br. J. Pharmacol. 122(2),217-224(1997).
2. Lawrence, R.A., and Jones, R.L. Investigation of the prostaglandin E (EP-) receptor subtype mediating relaxation of the rabbit jugular vein Br. J. Pharmacol. 105,817-824(1992).
3. Tani, K., Naganawa, A., Ishida, A., et al. Design and synthesis of a highly selective EP2-receptor agonist Bioorg. Med. Chem. Lett. 11,2025-2028(2001).

(+/-)-15-Deoxy-16r-hydroxy-17-cyclobutyl prostaglandin E1 Preparation Products And Raw materials

Raw materials

Preparation Products

(+/-)-15-Deoxy-16r-hydroxy-17-cyclobutyl prostaglandin E1 Suppliers

Global Suppliers ( 26)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 sales@molcore.com China 49709 58
(R)-BUTAPROST (FREE ACID) BUTAPROST (FREE ACID) 9-OXO-11ALPHA, 16S-DIHYDROXY-17-CYCLOBUTYL-PROST-13E-EN-1-OIC ACID 9-OXO-11ALPHA, 16R-DIHYDROXY-17-CYCLOBUTYL-PROST-13E-EN-1-OIC ACID (+/-)-15-DEOXY-16S-HYDROXY-17-CYCLOBUTYL PROSTAGLANDIN E1 PAYNQYXOKJDXAV-ZHIWTBQHSA-N Cyclopentaneheptanoic acid, 3-hydroxy-2-[(1E,4S)-4-hydroxy-4-(1-propylcyclobutyl)-1-buten-1-yl]-5-oxo-, (1R,2R,3R)- (S)-Butaprost (free acid) (+/-)-15-Deoxy-16r-hydroxy-17-cyclobutyl prostaglandin E1 433219-55-7