o-Toluidine hydrochloride
- CAS No.
- 636-21-5
- Chemical Name:
- o-Toluidine hydrochloride
- Synonyms
- nci-c02335;o-ToluidineHCL;2-Toluidine HCl;o-Tolidine hydroch;ORTHO-TOLUIDINEHCL;rcrawastenumberu222;o-Toluidine Chloride;Prilocaine impurity B;PRILOCAINE RC A/ORTHO;O-TOLUIDINIUM CHLORIDE
- CBNumber:
- CB6264228
- Molecular Formula:
- C7H10ClN
- Molecular Weight:
- 143.61
- MDL Number:
- MFCD00012959
- MOL File:
- 636-21-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 215-217 °C(lit.) |
|---|---|
| Boiling point | 242 °C |
| Density | 1.0968 (rough estimate) |
| refractive index | 1.5760 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| color | White to Grey |
| BRN | 3558629 |
| Stability | Stable. Incompatible with oxidizing agents, alkalies. Light and moisture sensitive. |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1S/C7H9N.ClH/c1-6-4-2-3-5-7(6)8;/h2-5H,8H2,1H3;1H |
| InChIKey | OGVXWEOZQMAAIM-UHFFFAOYSA-N |
| SMILES | C1(C)=CC=CC=C1N.Cl |
| Toxicology and Carcinogenesis | Bioassay of o-Toluidine Hydrochloride for Possible Carcinogenicity (CASRN 636-21-5) |
| CAS DataBase Reference | 636-21-5(CAS DataBase Reference) |
| FDA UNII | DX2X117B81 |
| Proposition 65 List | o-Toluidine Hydrochloride |
| EPA Substance Registry System | o-Toluidine hydrochloride (636-21-5) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H312+H332-H350 |
| Precautionary statements | P201-P261-P280-P308+P313 |
| Hazard Codes | T |
| Risk Statements | 45-20/21/22 |
| Safety Statements | 53-36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | XU7350000 |
| TSCA | TSCA listed |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| HS Code | 2921430000 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Carc. 1B |
| Hazardous Substances Data | 636-21-5(Hazardous Substances Data) |
o-Toluidine hydrochloride price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR3107 | Prilocaine Related Compound A pharmaceutical secondary standard, certified reference material | 636-21-5 | 200MG | $563 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1561019 | Prilocaine Related Compound A United States Pharmacopeia (USP) Reference Standard | 636-21-5 | 100mg | $1410 | 2026-04-30 | Buy |
| Biosynth | FT161143 | o-Toluidine hydrochloride | 636-21-5 | 5g | $150 | 2026-06-04 | Buy |
| Biosynth | FT161143 | o-Toluidine hydrochloride | 636-21-5 | 2g | $150 | 2026-06-04 | Buy |
| Biosynth | FT161143 | o-Toluidine hydrochloride | 636-21-5 | 1g | $150 | 2026-06-04 | Buy |
o-Toluidine hydrochloride Chemical Properties, Uses, Production
Chemical Properties
white crystalline powder
Uses
o-Toluidine and o-toluidine hydrochloride are used primarily as intermediates in the manufacture of more than 90 dyes and pigments (NCI 1979, IARC 1982, 2000). They are used in acid-fast dyestuffs, azo pigments and dyes, triarylmethane dyes, sulfur dyes, and indigo compounds and as a photographic dye. o-Toluidine is also used as an intermediate for synthetic rubber and rubber vulcanizing chemicals, pharmaceuticals, and pesticides and as a curing agent in epoxy resin systems. Other minor uses of o-toluidine and its hydrochloride salt are as an intermediate in organic synthesis and as an ingredient in a clinical laboratory reagent for glucose and hemoglobin analyses.
Uses
o-Toluidine Chloride is a carcinogenic and toxic aromatic amine contained in hair dye, henna and dyed hair samples. Prilocaine USP Related Compound A
General Description
Green crystals or white crystalline solid. Melting point 215-217°F. Highly toxic.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
O-TOLUIDINE HYDROCHLORIDE acts as a weak acid. Incompatible with oxidizing agents and with alkalis .
Fire Hazard
Flash point data for O-TOLUIDINE HYDROCHLORIDE are not available; however, O-TOLUIDINE HYDROCHLORIDE is probably combustible.
Safety Profile
Confirmed carcinogen with experimental carcinogenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also o- TOLUIDINE.
Synthesis
88-72-2
636-21-5
The general procedure for the synthesis of o-biphenylamine hydrochloride from o-nitrotoluene was as follows: the catalyst precursor in the form of 0.04 M CuSO4 and 0.004 M CoCl2 solution (3.0 ml, 3.0 mol/mol CuSO4, 0.3 mol/ml CoCl2) was added to magnetically stirred 25 ml methanol solution of o-nitrotoluene (4 mmol). The reaction was initiated by the addition of an initial portion of 210 mg (5.6 mmol) of NaBH4, and a change in the color of the reaction solution to black (in situ generated catalyst) accompanied by the escape of violent gases was observed. Subsequently, NaBH4 (7 × 35 mg, 7 × 0.9 mmol) was added in portions at 3 min intervals. The reaction was carried out at room temperature and atmospheric pressure, and due to the exothermic nature of the reaction, the temperature of the reaction mixture was usually raised to 30-40 °C, and additional cooling was usually not required for small-scale reactions. For large scale reactions (10 mmol), a reflux condenser needs to be connected. After 25 minutes of reaction, the reaction was quenched by adding 30 ml of water and extracted with 3 x 40 ml of CH2Cl2. The organic layers were combined and dried with MgSO4. After removal of the desiccant, an ether solution (10 ml) of 6 M HCl was added to form a more stable hydrochloride, followed by removal of excess HCl, CH2Cl2, and Et2O under reduced pressure (10 mmHg).The amine products were analyzed by GC-MS, 1H-NMR, and 13C-NMR. The NMR data of the compounds are listed in Table 2.
Carcinogenicity
o-Toluidine and o-toluidine hydrochloride are reasonably anticipatedto be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals.
References
[1] RSC Advances, 2015, vol. 5, # 57, p. 45760 - 45766
[2] Journal of Organic Chemistry, 1982, vol. 47, # 18, p. 3577 - 3581
[3] Organic Preparations and Procedures International, 2014, vol. 46, # 2, p. 176 - 182
o-Toluidine hydrochloride Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| UHN Shanghai Research & Development Co., Ltd. | 021-58958002 18930822973 | sales@uhnshanghai.com | China | 1983 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Maya High Purity Chemicals | +86 (573) 82222445 (0)18006601000 452520369 | sales@maya-r.com | China | 11693 | 57 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from o-Toluidine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | O-TOLUIDINE HYDROCHLORIDE
636-21-5
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- O-TOLUIDINE HYDROCHLORIDE
636-21-5
- $9.80
- ≥99%
- Career Henan Chemical Co
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