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2-Chloro-N-(2,6-dimethylphenyl)acetamide

2-Chloro-N-(2,6-dimethylphenyl)acetamide structure

CAS No.: 1131-01-7

Chemical Name:: 2-Chloro-N-(2,6-dimethylphenyl)acetamide

Synonyms: Lidocaine EP Impurity H;2-CHLORO-2',6'-ACETOXYLIDIDE;N-CHLOROACETYL-2,6-DIMETHYLANILINE;NSC 37260;2-Chloro-N-(2;acetoxylidide;AKOS BBS-00000875;LIDOCAINE EP IMP H;TIMTEC-BB SBB003566;IFLAB-BB F0133-0019

CBNumber:: CB0151081

Molecular Formula:: C10H12ClNO

Molecular Weight:: 197.66

MDL Number:: MFCD00000926

MOL File:: 1131-01-7.mol

MSDS File:: SDS

Last updated:2026-06-19 07:28:27

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2-Chloro-N-(2,6-dimethylphenyl)acetamide Properties

Melting point	150-151 °C(lit.)
Boiling point	316.8±30.0 °C(Predicted)
Density	1.1363 (rough estimate)
refractive index	1.5330 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Crystalline Powder or Needles
pka	12.91±0.70(Predicted)
color	White to brown
Water Solubility	Soluble in Chloroform, Methanol. Insoluble in water.
BRN	781309
Stability	Light Sensitive
InChI	1S/C10H12ClNO/c1-7-4-3-5-8(2)10(7)12-9(13)6-11/h3-5H,6H2,1-2H3,(H,12,13)
InChIKey	FPQQSNUTBWFFLB-UHFFFAOYSA-N
SMILES	Cc1cccc(C)c1NC(=O)CCl
CAS DataBase Reference	1131-01-7(CAS DataBase Reference)
FDA UNII	5D2B69OAPX
NIST Chemistry Reference	2-Chloro-2',6'-acetoxylidide(1131-01-7)
EPA Substance Registry System	Acetamide, 2-chloro-N-(2,6-dimethylphenyl)- (1131-01-7)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39

WGK Germany

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29214200

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

REACH Registrations

Active

NFPA 704

	1
2		0

2-Chloro-N-(2,6-dimethylphenyl)acetamide price More Price(64)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR1673	N-(2,6-Dimethylphenyl)chloroacetamide Pharmaceutical Secondary Standard; Certified Reference Material	1131-01-7	100mg	$801	2026-04-30	Buy
Sigma-Aldrich	194921	N-(2,6-Dimethylphenyl)chloroacetamide 99%	1131-01-7	10g	$86.9	2026-04-30	Buy
Sigma-Aldrich	1366080	Lidocaine Related Compound H United States Pharmacopeia (USP) Reference Standard	1131-01-7	50MG	$1570	2026-04-30	Buy
TCI Chemical	C2307	2-Chloro-2',6'-dimethylacetanilide >98.0%(GC)(N)	1131-01-7	5g	$35	2026-04-30	Buy
TCI Chemical	C2307	2-Chloro-2',6'-dimethylacetanilide >98.0%(GC)(N)	1131-01-7	25g	$85	2026-04-30	Buy

Product number	Packaging	Price	Buy
PHR1673	100mg	$801	Buy
194921	10g	$86.9	Buy
1366080	50MG	$1570	Buy
C2307	5g	$35	Buy
C2307	25g	$85	Buy

2-Chloro-N-(2,6-dimethylphenyl)acetamide Chemical Properties, Uses, Production

Chemical Properties

beige needles or crystalline powder

Uses

Lidocaine intermediate.

Uses

2-Chloro-2',6'-dimethylacetanilide is used in the determination of the enantiomers of tocainide in blood plasma by gas-liquid chromatography with electron-capture detection. It is a nonsteroidal antinflammatory drug.

General Description

N-(2,6-Dimethylphenyl)chloroacetamide (2-chloro-2′,6′-acetoxylidide) is nonsteroidal antinflammatory drug.

Synthesis

593-71-5

28556-81-2

2-Chloro-N-(2,6-dimethylphenyl)acetamide

1131-01-7

General method: Chloroiodomethane (1.5 eq.) is slowly added to a solution of 2,6-dimethylphenyl isocyanate (1.0 eq.) in anhydrous ether (1 M concentration) at -78 °C. After 2 minutes of reaction, a 1.5 M solution of methyl lithium-lithium bromide (1.25 equiv.) ether was added dropwise over 5 minutes. Maintaining this temperature, the reaction mixture was stirred for the indicated time (see Table 1 and Scheme 2 for specific times). Upon completion of the reaction, aqueous ammonium chloride solution (2 mL/mmol substrate) was added, the cooling bath was removed, and stirring was continued until the mixture was brought to room temperature. Subsequently, the reaction mixture was extracted with ether (2 x 5 mL) and the organic phase was washed sequentially with water (5 mL) and brine (10 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give pure 2,6-dimethylchloroacetanilide.

References

[1] Chemical Communications, 2013, vol. 49, # 75, p. 8383 - 8385
[2] Synthesis (Germany), 2014, vol. 46, # 21, p. 2897 - 2909

2-Chloro-N-(2,6-dimethylphenyl)acetamide synthesis

Synthesis of 2-Chloro-N-(2,6-dimethylphenyl)acetamide from 2,6-Dimethylaniline

2-Chloro-N-(2,6-dimethylphenyl)acetamide Preparation Products And Raw materials

Raw materials

N-Methylaniline Anhydrous benzene Chloroacetyl chloride Chloroiodomethane 2,6-Dimethylaniline

2,6-Dimethyl-1-nitrobenzene 2,6-Dimethylphenyl isocyanate Sodium acetate Sodium bicarbonate Chloroacetic anhydride

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Preparation Products

Pyrazole Nefiracetam Lidocaine Impurity

2-Chloro-N-(2,6-dimethylphenyl)acetamide Suppliers

Global Suppliers ( 406)

Supplier	Tel	Email	Country	ProdList	Advantage
Z IntellecChem& Tech. Co., Ltd	0511-15050866711; 15050866711	contact@zintellec.com	China	93	62
Jinan Shengqi Pharmaceutical Co., Ltd	0531-82687819 15610111696	xgc01@orgachem.com	China	176	58
Shandong Kanghong New Material Technology Co., Ltd	17686625089; 17686625089	shandongkanghong@qq.com	China	102	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66

Supplier	Advantage
Z IntellecChem& Tech. Co., Ltd	62
Jinan Shengqi Pharmaceutical Co., Ltd	58
Shandong Kanghong New Material Technology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TAIYUAN RHF CO.,LTD.	56
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Capot Chemical Co., Ltd	66

View Latest Price from 2-Chloro-N-(2,6-dimethylphenyl)acetamide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-16	2-Chloro-N-(2,6-dimethylphenyl)acetamide 1131-01-7		1KG	98%min	500kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-08-10	2-Chloro-N-(2,6-dimethylphenyl)acetamide 1131-01-7	$1.00	1kg	98	1000	S&Y Biochem Co.,Ltd
2026-06-30	2-Chlor-2',6'-dimethylacetanilid 1131-01-7		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd

2-Chloro-N-(2,6-dimethylphenyl)acetamide
1131-01-7
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

2-Chloro-N-(2,6-dimethylphenyl)acetamide
1131-01-7
$1.00
98
S&Y Biochem Co.,Ltd

2-Chlor-2',6'-dimethylacetanilid
1131-01-7
98%
Shaanxi Dideu New Materials Co. Ltd

2-Chloro-N-(2,6-dimethylphenyl)acetamide Spectrum

2-Chloro-N-(2,6-dimethylphenyl)acetamide(1131-01-7)MS 2-Chloro-N-(2,6-dimethylphenyl)acetamide(1131-01-7)¹HNMR 2-Chloro-N-(2,6-dimethylphenyl)acetamide(1131-01-7)¹³CNMR 2-Chloro-N-(2,6-dimethylphenyl)acetamide(1131-01-7)IR1 2-Chloro-N-(2,6-dimethylphenyl)acetamide(1131-01-7)IR2 2-Chloro-N-(2,6-dimethylphenyl)acetamide(1131-01-7)Raman

1131-01-7 (2-Chloro-N-(2,6-dimethylphenyl)acetamide) Related Search:

Chloroacetamide 4'-Nitroacetanilide 4'-Aminoacetanilide N,N-Dimethyl-1,4-phenylenediamine N-Acetylsulfanilyl chloride

N,N-Dimethylaniline p-Acetotoluidide Acetaminophen Acetamide N,N-Dimethylacetamide

2-Benzoylacetanilide Difluorochloromethane Metazachlor Machette Alachlor

Diethatyl ethyl Metolachlor DIMETHACHLOR

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Chloro-2',6'-diMethylacetanilide 2',6'-DiMethyl-2-chloroacetanilide ChloroacetaMido-2,6-xylidine N-(2,6-Xylyl)chloroacetaMide NSC 37260 2-Chloro-N-(2,6-dimethylphenyl)acetamide2-Chloro-N-(2,6-dimethylphenyl)acetamide 2-Chloro-N-(2 6-diMethylphenyl)acetaMide N-(2,6-Dimethylphenyl)chloroacetamide 99% 2-Chloro-N-(2,6-dimethylphenyl)acetamide 2-Chloro-2',6'-acetoxylidide 2',6'-Acetoxylidide, 2-chloro- (8CI) 2-chloro-N-(2,6-dimethylphenyl)ethanamide acetoxylidide N-(2,6-Dimethylphenyl)chloroacetamide Lidocaine Impurity H(EP) Lidocaine Impurity 8(Lidocaine EP Impurity H) Lidocaine BP Impurity H JR-8652, 2-Chloro-N-(2,6-dimethylphenyl)acetamide, 97% 2-Chlor-2',6'-dimethylacetanilid Acetamide, 2-chloro-N-(2 1-Chloroacetylamino-2,6-dimethylbenzene 2',6'-Acetoxylidide, 2-chloro- 2-Chloro-2',6'-dimethylacetanilide 2-Chloroaceto-2,6-xylidide 2-chloro-n-(2,6-dimethylphenyl)-acetamid Acetamide, 2-chloro-N-(2,6-dimethylphenyl)- Chloroacet-2,6-xylide Chloroaceto-2,6-xylidide N-CHLORACETYL-2,6-DIMETHYLANILINE TIMTEC-BB SBB003566 2-CHLORO-N-(2,6-DIMETHYLPHENYL)ACETAMIDE AKOS BBS-00000875 CHLOROACETYL-2,6-DIMETHYLANILINE IFLAB-BB F0133-0019 Chloroaceto-2,6-xylidide~alpha-Chloro-2,6-dimethylacetanilide à-chloro-2,6-dimethylacetanilide ALPHA-Chloro-2'',6''-dimethylacetanilide N-(Chloroacetyl)-2,6-diethylaniline 2-Chlorl-N-(2,6-dimethylpheny)acetamide 2-CHLORO-2'',6''-DIMETHYLACETANILIDE (LIDOCAINE) CHLORO ACETYL XYLIDIDE 2-Chloro-N-(2,6-dimethylphenyl)acetamide,98% Lidocaine Impurity H Reference 2-Chloro-2',6'-dimethylacetanilide > Lidocaine hydrochloride impurity888 LIDOCAINE HYDROCHLORIDE EP IMPURITY H Lidocaine EP Impurity H（2-chloro-N-(2,6-dimethylphenyl)acetamide） Lidocaine Related Compound H (2-Chloro-N-(2,6-dimethylphenyl)acetamide) (1366080) 10-PHENOXYPHENYLACETIC&ACID Lidocaine USP Related Compound H ChloroAcetyl Xylidine?(N-Chloroacetyl 2,6 Dimethylaniline) 2-Chloro-N-(2,6- dimethylphenyl)acet amide / CAX Base 2-Chloro-N - (2,6-xylenyl) acetamide 2-Chloro-2',6'-dimethylacetanilide, ≥ 98.0% LIDOCAINE EP IMP H 2-Chloro-2',6'-dimethylacetanilide / Lidocaine EP Impurity H Lidocaine EP Impurity 8 Lidocaine EP Impurity H (Lidocaine USP Related Compound H)