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ChemicalBook >> CAS DataBase List >>N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide

N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide

N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide Structure
N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide structure
CAS No.
253168-86-4
Chemical Name:
N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide
Synonyms
N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide;rac-Apremilast;(+/-)-Apremilast;Apremilast Impurity 70;Apremilast Impurity E (racemate);Apremilast Impurity 44（rac-Apremilast）;N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide;Acetamide, N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-
CBNumber:
CB62703798
Molecular Formula:
C22H24N2O7S
Molecular Weight:
460.5
MDL Number:
MFCD22543851
MOL File:
253168-86-4.mol
MSDS File:
SDS
Last updated:2025-04-18 09:51:20
Product description Number Pack Size Price
N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide >98% E60636 100mg $1580
N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide >98% E60636 250mg $4740
N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide >98% E60636 1g $18960
N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide >98% AA0039TM 100mg $1781
N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide 98% W170143 100MG $345
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N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide Properties

Boiling point 741.3±60.0 °C(Predicted)
Density 1.381±0.06 g/cm3(Predicted)
pka 14.01±0.20(Predicted)
form Solid
color Light yellow to yellow
FDA UNII N5UK68MGDZ

N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Synthonix E60636 N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide >98% 253168-86-4 100mg $1580 2026-05-06 Buy
Synthonix E60636 N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide >98% 253168-86-4 250mg $4740 2026-05-06 Buy
Synthonix E60636 N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide >98% 253168-86-4 1g $18960 2026-05-06 Buy
aablocks AA0039TM N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide >98% 253168-86-4 100mg $1781 2026-05-28 Buy
ACHEMBLOCK W170143 N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide 98% 253168-86-4 100MG $345 2026-05-27 Buy
Product number Packaging Price Buy
E60636 100mg $1580 Buy
E60636 250mg $4740 Buy
E60636 1g $18960 Buy
AA0039TM 100mg $1781 Buy
W170143 100MG $345 Buy

N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide Chemical Properties,Uses,Production

Uses

(Rac)-Apremilast ((Rac)-CC-10004) is the racemic mixture of Apremilast. (Rac)-Apremilast has anti-inflammatory properties and can be used for research on inflammatory diseases, such as psoriasis[1][2].

IC 50

hPDE4D: 0.3 nM (IC50)

References

[1] Armstrong AW, et al. Deucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: Efficacy and safety results from the 52-week, randomized, double-blinded, placebo-controlled phase 3 POETYK PSO-1 trial. J Am Acad Dermatol. 2023 Jan;88(1):29-39. DOI:10.1016/j.jaad.2022.07.002
[2] Man H W, et al. Discovery of (S)-N-{2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1, 3-dioxo-2, 3-dihydro-1 H-isoindol-4-yl} acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-α inhibitor[J]. Journal of medicinal chemistry, 2009, 52(6): 1522-1524.

N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide Suppliers

Global( 34)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19935 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 marketing1@neostarunited.com China 8827 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
AFINE CHEMICALS LIMITED 		+86-571-85134551 +86-18958018566 info@afinechem.com China 15050 58
QUALITY CONTROL SOLUTIONS LTD. 		+86-0755-66853366 +86-13670046396 export03@qcsrm.com China 24318 58
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Suzhou Carbonwell Pharma-Tech Co., Ltd 0512-0512-88981216 13776013740 1320558046@qq.com China 72 58
Zhongshan Haihong Medicine Co. Ltd 0760-86925768 18824993998 seas168@126.com China 60 58
Quality Control Solutions Ltd. 0755-66853366 13670046396 orders@qcsrm.com China 18188 56
Shanghai Kewel Chemical Co., Ltd. 021-64609169 18901607656 greensnown@163.com China 9883 50
Supplier Advantage
BOC Sciences 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
AFINE CHEMICALS LIMITED 		58
QUALITY CONTROL SOLUTIONS LTD. 		58
Adamas Reagent, Ltd. 59
Suzhou Carbonwell Pharma-Tech Co., Ltd 58
Zhongshan Haihong Medicine Co. Ltd 58
Quality Control Solutions Ltd. 56
Shanghai Kewel Chemical Co., Ltd. 50

253168-86-4(N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide)Related Search:

Apremilast Impurity 84 3-Ethoxy-4-methoxy benzonitrile 3-Nitrophthalic acid Apremilast Impurity 19 Apremilast Impurity 15
Apremilast impurity 18 1H-Isoindole-1,3(2H)-dione, 2-[1-(3-ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethyl]- 4-acetamidophthalic acid 1-Methyl-3-nitrophthalate 4-Nitrophthalic acid
Apremilast Impurity 4 BenzeneMethanaMine, 4-ethoxy-3-Methoxy-a-[(Methylsulfonyl)Methyl]- Apremilast-d8 Apremilast Impurity 25 1-(3,4-Diethoxyphenyl)-2-(methylsulfonyl)ethan-1-amine
Apremilast Impurity 28 (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Apremilast Impurity 34

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N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide rac-Apremilast Acetamide, N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- Apremilast Impurity 70 (+/-)-Apremilast Apremilast Impurity E (racemate) N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide Apremilast Impurity 44（rac-Apremilast） 253168-86-4