4-Nitrophthalic acid
- CAS No.
- 610-27-5
- Chemical Name:
- 4-Nitrophthalic acid
- Synonyms
- 4-NPA;5-NITROPHTHALIC ACID;1,2-Benzenedicarboxylic acid, 4-nitro-;NSC 5395;4-NO2-PA;AKOS B028755;4-NitrophthaL;4-Nitrophthalic;4-nitro-phthalate;4-Nitrophthalicaci
- CBNumber:
- CB3467453
- Molecular Formula:
- C8H5NO6
- Molecular Weight:
- 211.13
- MDL Number:
- MFCD00007252
- MOL File:
- 610-27-5.mol
- MSDS File:
- SDS
| Melting point | 159-161 °C (lit.) |
|---|---|
| Boiling point | 350.79°C (rough estimate) |
| Density | 1.6342 (rough estimate) |
| refractive index | 1.5282 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 880g/l |
| form | Crystalline Powder |
| pka | pK1:2.11 (25°C) |
| color | Yellow to beige |
| PH | 1 (10g/l, H2O, 20℃) |
| Odor | Odorless |
| PH Range | 1 |
| Water Solubility | 880 g/l at 20 °C |
| BRN | 1882262 |
| InChI | 1S/C8H5NO6/c10-7(11)5-2-1-4(9(14)15)3-6(5)8(12)13/h1-3H,(H,10,11)(H,12,13) |
| InChIKey | SLBQXWXKPNIVSQ-UHFFFAOYSA-N |
| SMILES | OC(=O)c1ccc(cc1C(O)=O)[N+]([O-])=O |
| CAS DataBase Reference | 610-27-5(CAS DataBase Reference) |
| FDA UNII | KGN4549BTD |
| EPA Substance Registry System | 1,2-Benzenedicarboxylic acid, 4-nitro- (610-27-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29173980 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Nitrophthalic acid price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 274755 | 4-Nitrophthalic acid 92% | 610-27-5 | 25g | $95.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | 274755 | 4-Nitrophthalic acid 92% | 610-27-5 | 5g | $35.8 | 2023-06-20 | Buy |
| TCI Chemical | N0244 | 4-Nitrophthalic Acid >98.0%(HPLC)(T) | 610-27-5 | 25g | $45 | 2026-04-30 | Buy |
| TCI Chemical | N0244 | 4-Nitrophthalic Acid >98.0%(HPLC)(T) | 610-27-5 | 500g | $536 | 2026-04-30 | Buy |
| TRC | TRC-N515300-5G | 4-Nitrophthalic Acid | 610-27-5 | 5g | $73 | 2026-06-03 | Buy |
4-Nitrophthalic acid Chemical Properties, Uses, Production
Chemical Properties
Light-Beige Solid
Uses
4-Nitrophthalic Acid is an impurity of Apremilast.
General Description
The tissue-specific activity of 4-nitrophthalic acid was studied.
Synthesis
31643-49-9
610-27-5
The general procedure for the synthesis of 4-nitrophthalic acid from 4-nitrophthalonitrile was as follows: 4-nitrophthalonitrile (2 mmol) was dissolved in 5 ml of [bmim]HSO4 ionic liquid and the reaction mixture was heated at 60-65°C for 1-3 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was poured into water containing crushed ice to induce precipitation of the product. Subsequently, the precipitate is collected by filtration and dried. The product yield of this method was generally higher than 90% and the purity of the product met the requirements without further purification. The filtrate was concentrated under vacuum, washed twice with diethyl ether and concentrated again under high vacuum. After drying, about 95% of the ionic liquid was recovered, and its authenticity was verified by comparison with the original ionic liquid. The recovered ionic liquid showed comparable efficiency to the original ionic liquid in the reaction of converting nitrile to acid and could be reused 5-6 times without significant reduction in activity.
Purification Methods
Crystallise 4-nitrophthalic acid from Et2O, EtOAc or *C6H6 (m 166o). The amide has m 200o (from EtOH). [Beilstein 9 H 828, 9 IV 4234.]
References
[1] Tetrahedron Letters, 2014, vol. 55, # 28, p. 3802 - 3804
4-Nitrophthalic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Greenspring Biotechnology (Jiangsu) Co., Ltd. | 0523-87726088 13705266400 | 524535288@qq.com | China | 117 | 58 |
| Shanxi Libolong New Materials Co., Ltd | 19135980588 | 13935924147@163.cn | China | 17 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
View Latest Price from 4-Nitrophthalic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | 4-Nitrophthalic acid
610-27-5
|
$44.65 | 25Kg/Drum | 99.00%HPLC | 3tons/month | Asia Chem I and E (Jiangsu) Co Ltd | |
 |
2026-05-28 | 4-Nitrophthalic acid
610-27-5
|
$10.70 | 10kg | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-03-12 | Pomalidomide Impurity 44
610-27-5
|
10mg | 98% | 500mg | ShenZhen H&D Pharmaceutical Technology Co., LTD |
-
- 4-Nitrophthalic acid
610-27-5
- $44.65
- 99.00%HPLC
- Asia Chem I and E (Jiangsu) Co Ltd
-
- 4-Nitrophthalic acid
610-27-5
- $10.70
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- Pomalidomide Impurity 44
610-27-5
- 98%
- ShenZhen H&D Pharmaceutical Technology Co., LTD
