Succinyl phosphonate
- CAS No.
- 26647-82-5
- Chemical Name:
- Succinyl phosphonate
- Synonyms
- Butanoic acid, 4-oxo-4-phosphono-
- CBNumber:
- CB62736697
- Molecular Formula:
- C4H4O8P2-4
- Molecular Weight:
- 242.017282
- MDL Number:
- MFCD28900668
- MOL File:
- 26647-82-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H332 |
| Precautionary statements | P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362-P403+P233-P501 |
Succinyl phosphonate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Crysdot | CD31002462 | Succinyl phosphonate 98+% | 26647-82-5 | 5mg | $243 | 2026-05-27 | Buy |
| Crysdot | CD31002462 | Succinyl phosphonate 98+% | 26647-82-5 | 10mg | $347 | 2026-05-27 | Buy |
| CSNpharm | CSN18172 | SuccinylPhosphonate | 26647-82-5 | 1mg | $140 | 2021-12-16 | Buy |
| CSNpharm | CSN18172 | SuccinylPhosphonate | 26647-82-5 | 10mg | $480 | 2021-12-16 | Buy |
Succinyl phosphonate Chemical Properties, Uses, Production
Uses
Succinyl phosphonate is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts[1][4]. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner[2]. Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ[3].
References
[1] Biryukov AI, et al. Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle. FEBS Lett. 1996 Mar 11;382(1-2):167-70. DOI:10.1016/0014-5793(96)00166-4
[2] Bunik VI, et al. Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutaratedehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 2005 Aug 9;44(31):10552-61. DOI:10.1021/bi0503100
[3] Zündorf G, et al. alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ. Neuroscience. 2009 Jan 23;158(2):610-6. DOI:10.1016/j.neuroscience.2008.10.015
[4] Bunik VI, et al. Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 2005 Aug 9;44(31):10552-61. DOI:10.1021/bi0503100
Succinyl phosphonate Preparation Products And Raw materials
Raw materials
Preparation Products
Succinyl phosphonate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
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| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4648 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| ChemeGen | 18818260767 | 2625930290@qq.com | China | 6966 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 50706066 15221275939 | shenlinxing@macklin.cn | China | 14849 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
