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ChemicalBook >> CAS DataBase List >>6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Structure
6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine structure
CAS No.
914612-23-0
Chemical Name:
6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
Synonyms
CIVENTICHEM CV-5309;6-benzyl-4-chloro-5;6-Benzyl-4-chloro-5,6,7,8...;6-benzyl-4-chloro-5H,6H,7H,8H-pyrido[4,3-d]pyriMidine;6-benzyl-4-chloro-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine;-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE;6-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE;Pyrido[4,3-d]pyrimidine, 4-chloro-5,6,7,8-tetrahydro-6-(phenylmethyl)-;6-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE ISO 9001：2015 REACH
CBNumber:
CB6290209
Molecular Formula:
C14H14ClN3
Molecular Weight:
259.73
MDL Number:
MFCD08273929
MOL File:
914612-23-0.mol
MSDS File:
SDS
Last updated:2026-05-28 01:27:33
Product description Number Pack Size Price
6-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE 97% 52650 0.25G $145
6-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE 97% 52650 1G $259
6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine 070201 1.00g $151
6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine 070201 5.00g $449
6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine 070201 10.00g $785
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6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Properties

Boiling point 396.6±42.0 °C(Predicted)
Density 1.273±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 5.01±0.20(Predicted)
Appearance Light yellow to yellow Powder
InChI InChI=1S/C14H14ClN3/c15-14-12-9-18(7-6-13(12)16-10-17-14)8-11-4-2-1-3-5-11/h1-5,10H,6-9H2
InChIKey RPJAAZOTUXKSEV-UHFFFAOYSA-N
SMILES C1=NC(Cl)=C2CN(CC3=CC=CC=C3)CCC2=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AstaTech 52650 6-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE 97% 914612-23-0 0.25G $145 2026-04-30 Buy
AstaTech 52650 6-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE 97% 914612-23-0 1G $259 2026-04-30 Buy
Matrix Scientific 070201 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine 914612-23-0 1.00g $151 2026-05-18 Buy
Matrix Scientific 070201 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine 914612-23-0 5.00g $449 2026-05-18 Buy
Matrix Scientific 070201 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine 914612-23-0 10.00g $785 2026-05-18 Buy
Product number Packaging Price Buy
52650 0.25G $145 Buy
52650 1G $259 Buy
070201 1.00g $151 Buy
070201 5.00g $449 Buy
070201 10.00g $785 Buy

6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Chemical Properties,Uses,Production

Uses

Pyridine [4,3-D]pyrimidine compounds are nitrogen-containing heterocyclic compounds with unique structures and functions, occupying a very important position in organic chemistry and becoming one of the hot topics in chemical research today. Pyridine [4,3-D]pyrimidine derivatives possess biological activities such as antibacterial, anticancer, anti-inflammatory, antidiabetic, and antiviral activity, and their synthesis has attracted much attention.

Synthesis

A mixture of 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (5.0 g, 0.02 mol), phosphoryl chloride(3.30 mL, 0.035 mol), acetonitrile (80 mL) and DMF (catalytic amount) was heated to at 70° C for 1 hour. The mixture was reduced in vacuo and the remaining black residue was taken up in dichloromethane (250 ml) and poured over ice. The mixture was carefully neutralized with the addition of solid sodium bicarbonate. The layers were separated and the organic dried over sodium sulfate and reduced in vacuo. The mixture was chromatographed using an ethyl acetate: hexanes gradient on an isco flash chromatography system. The combined pure fractions were reduced in vacuo to yield 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine as a yellow oil.

References

[1] Patent: US2006/258689, 2006, A1. Location in patent: Page/Page column 23; 28
[2] Patent: US2008/275037, 2008, A1. Location in patent: Page/Page column 23
[3] Patent: WO2008/123963, 2008, A1. Location in patent: Page/Page column 44
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 11, p. 3124 - 3132
[5] Patent: WO2011/103715, 2011, A1. Location in patent: Page/Page column 40

6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one Dichloromethane trichlorophosphate N,N-Dimethylformamide Sodium bicarbonate
Acetonitrile

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Preparation Products

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6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Suppliers

Global( 95)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29812 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49979 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Hubei Ipure Biology Co., Ltd 		+8618062405514 ada@ipurechemical.com China 10236 58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		86 18062405514 18062405514 ada@ipurechemical.com CHINA 3461 58
ANHUI WITOP BIOTECH CO., LTD 		+8618071025641 eric@witopchemical.com China 23541 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 +86-17392587031 1059@dideu.com China 9996 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 17705817739 info@dycnchem.com China 52704 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
career henan chemical co 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Hubei Ipure Biology Co., Ltd 		58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58

View Lastest Price from 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE pictures 2025-06-25 6-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE
914612-23-0
 $1.10 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
6-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE pictures 2019-09-03 6-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE
914612-23-0
 $7.00 1KG 99% Career Henan Chemical Co

6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Spectrum

6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine(914612-23-0)1HNMR

914612-23-0(6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine)Related Search:

Pyrido[4,3-d]pyrimidine, 4-chloro-5,6,7,8-tetrahydro- 6-benzyl-4-chloro-2-(methylsulfanyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine 6-BENZYL-2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE 6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE
Pyrido[4,3-d]pyrimidine, 4-chloro-5,6,7,8-tetrahydro-6-(phenylmethyl)-, hydrochloride (1:1)

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6-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE -BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE 6-Benzyl-4-chloro-5,6,7,8... 6-benzyl-4-chloro-5 6-benzyl-4-chloro-5H,6H,7H,8H-pyrido[4,3-d]pyriMidine CIVENTICHEM CV-5309 Pyrido[4,3-d]pyrimidine, 4-chloro-5,6,7,8-tetrahydro-6-(phenylmethyl)- 6-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE ISO 9001：2015 REACH 6-benzyl-4-chloro-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine 914612-23-0 pyrimidine Heterocycle-Pyrimidine series