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Z-LEU-LEU-GLU-AMC

Z-LEU-LEU-GLU-AMC structure

CAS No.: 348086-66-8

Chemical Name:: Z-LEU-LEU-GLU-AMC

Synonyms: Z-ILE-AMC;Z-LLE-AMC;Z-LLG-AMC;Z-LEU-LEU-GLU-MCA;Z-LEU-LEU-GLU-AMC;Z-LEU-LEU-GLY-AMC;CBZ-LEU-LEU-GLU-AMC;Proteasome Substrate II;Cbz-Leu-Leu-Glu-AMC, Z-LLE-AMC;PROTEASOME SUBSTRATE II (FLUOROGENIC)

CBNumber:: CB6298942

Molecular Formula:: C35H44N4O9

Molecular Weight:: 664.75

MDL Number:: MFCD01074989

MOL File:: 348086-66-8.mol

Last updated:2025-08-21 22:16:43

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Z-LEU-LEU-GLU-AMC Properties

Boiling point	967.8±65.0 °C(Predicted)
Density	1.253±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: soluble
form	solid
pka	4.43±0.10(Predicted)
color	Solid lyophilized powder
Sequence	{Z}-Leu-Leu-Glu-{AMC}
UNSPSC Code	12352209
NACRES	NA.77

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3

Z-LEU-LEU-GLU-AMC price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C0483	Z-Leu-Leu-Glu-7-amido-4-methylcoumarin ≥95%, solid	348086-66-8	5MG	$426	2025-07-31	Buy
Sigma-Aldrich	539141	Proteasome Substrate II, Fluorogenic Fluorogenic proteasome substrate.		5 mg	$288	2025-07-31	Buy
Cayman Chemical	10008117	Z-LLE-AMC ≥95%	348086-66-8	1mg	$44	2024-03-01	Buy
Cayman Chemical	10008117	Z-LLE-AMC ≥95%	348086-66-8	5mg	$130	2024-03-01	Buy
Cayman Chemical	10008117	Z-LLE-AMC ≥95%	348086-66-8	10mg	$235	2024-03-01	Buy

Product number	Packaging	Price	Buy
C0483	5MG	$426	Buy
539141	5 mg	$288	Buy
10008117	1mg	$44	Buy
10008117	5mg	$130	Buy
10008117	10mg	$235	Buy

Z-LEU-LEU-GLU-AMC Chemical Properties,Uses,Production

Description

Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment.

Uses

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin has been used as a fluorogenic substrate for peptidyl glutamyl peptide hydrolase (PGPH) in rat soleus muscle, neonatal cardiomyocytes and rat brain samples.

Uses

A fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (caspase-like) activity of the proteasome which may be stimulated in the presence of Mg2+ ions and rapidly inactivated by N-acetylimidazole

General Description

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin is a fluoropeptide. It acts as a substrate for caspase-like activity.

Biochem/physiol Actions

Fluorogenic substrate for the measurement of the peptidylglutamyl-peptide hydrolyzing activity of the 20S proteasome.

storage

+4°C

References

[1] MARIAN ORLOWSKI. Regulation of the peptidylglutamyl-peptide hydrolyzing activity of the pituitary multicatalytic proteinase complex[J]. Biochemistry Biochemistry, 1991, 30 24: 5999-6005. DOI: 10.1021/bi00238a025
[2] ELKE GEIER. A Giant Protease with Potential to Substitute for Some Functions of the Proteasome[J]. Science, 1999, 283 5404. DOI: 10.1126/science.283.5404.978
[3] MOHAMED-AMINE HAMOUDA. The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells.[J]. Oncotarget, 2014, 5 15: 6252-6266. DOI: 10.18632/oncotarget.2193
[4] LAURA TADLOCK. Transforming growth factor-beta inhibition of proteasomal activity: a potential mechanism of growth arrest.[J]. American journal of physiology. Cell physiology, 2003, 285 2: C277-85. DOI: 10.1152/ajpcell.00550.2002

Z-LEU-LEU-GLU-AMC Preparation Products And Raw materials

Raw materials

Preparation Products

Z-LEU-LEU-GLU-AMC Suppliers

Global( 103)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32432	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30229	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10473	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	Cecilia@youngshechem.com	China	2345	58
Nanjing TGpeptide	+86-13347807150	support@tgpeptide.com	China	3279	58
Changsha MOL Changes Biotechnology Co., Ltd.	+8619375158599	info@molchanges.com	China	5218	58
DONBOO AMINO ACID COMPANY	+8618051385538	donboo@donboo.com	China	9363	58
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64

Supplier	Advantage
BOC Sciences	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Zhejiang J&C Biological Technology Co.,Limited	58
Nextpeptide Inc	58
Chengdu Youngshe Chemical Co., Ltd.	58
Nanjing TGpeptide	58
Changsha MOL Changes Biotechnology Co., Ltd.	58
DONBOO AMINO ACID COMPANY	58
VDM Biochemicals	64

View Lastest Price from Z-LEU-LEU-GLU-AMC manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-08-21	Z-LLE-AMC 348086-66-8	US $852.00-468.00 / mg			10g	TargetMol Chemicals Inc.

Z-LLE-AMC
348086-66-8
US $852.00-468.00 / mg
TargetMol Chemicals Inc.

348086-66-8(Z-LEU-LEU-GLU-AMC)Related Search:

Z-LEU-LEU-ARG-AMC Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN Z-LEU-LEU-OH Z-LLL-AMC BENZYLOXYCARBONYL-L-LEUCYL-L-ARGINYLGLYCYLGLYCINE 4-METHYLCOUMARYL-7-AMIDE

H-GLU(AMC)-OH MG-115 Z-LEU-LEU-GLU-AMC Z-LEU-LEU-GLU-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN GLUTAMIC ACID(ANILIDE)-OH

1of2

CBZ-LEU-LEU-GLU-AMC CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-GLUTAMIC-ACID-ALPHA-(4-METHYLCOUMARINYL)-7-AMIDE BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-GLUTAMIC ACID ALPHA-(4-METHYLCOUMARYL-7-AMIDE) PROTEASOME SUBSTRATE II (FLUOROGENIC) Z-LEU-LEU-GLU-7-AMIDO-4-METHYLCOUMARIN Z-LEU-LEU-GLU-7-AMINO-4-METHYLCOUMARIN Z-LEU-LEU-GLU-AMC Z-LEU-LEU-GLU-MCA Z-LLE-AMC Z-ILE-AMC N-[(Phenylmethoxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-alpha-glutamine Z-LLG-AMC (5S,8S,11S)-5,8-Diisobutyl-11-((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatetradecan-14-oic acid Cbz-Leu-Leu-Glu-AMC, Z-LLE-AMC Z-LEU-LEU-GLY-AMC benzyloxycarbonyl-L-leucyl-L-leucyl-L-glutamic acid α-(4-methylcoumaryl-7-amide) Proteasome Substrate II L-α-Glutamine, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- 348086-66-8 C35H44N4O9 Proteasome substrate II.