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MG-115

MG-115 structure

CAS No.: 133407-86-0

Chemical Name:: MG-115

Synonyms: MG-115;Z-LLnV;(S)-MG115;Z-LL-NVA-CHO;MG115, Z-LLnV;Z-LEU-LEU-NVA-H;Z-LEU-LEU-NVA-CHO;z-leu-leu-norvalinal;Z-LEU-LEU-NVA-ALDEHYDE;MG-115 (DMSO solution)

CBNumber:: CB0195607

Molecular Formula:: C25H39N3O5

Molecular Weight:: 461.6

MDL Number:: MFCD00274411

MOL File:: 133407-86-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:55

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MG-115 Properties

Boiling point	678.8±55.0 °C(Predicted)
Density	1.082±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: soluble
form	powder
pka	11.14±0.46(Predicted)
color	white
InChIKey	WVUWUETVYUPHEM-FKBYEOEOSA-N
SMILES	C(N)(=O)[C@H](CC(C)C)N(C(=O)[C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)[C@H](C=O)CCC
UNSPSC Code	12352209
NACRES	NA.77

SAFETY

Risk and Safety Statements

WGK Germany	3
Storage Class	11 - Combustible Solids

MG-115 price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	474780	MG-115 Potent reversible proteasome inhibitor (K	133407-86-0	5mg	$285	2026-04-30	Buy
Sigma-Aldrich	C6706	Z-Leu-Leu-Norvalinal ≥90% (HPLC), powder	133407-86-0	1mg	$99.3	2023-06-20	Buy
Cayman Chemical	15413	(S)-MG115 ≥95%	133407-86-0	1mg	$57	2026-04-30	Buy
Cayman Chemical	15413	(S)-MG115 ≥95%	133407-86-0	5mg	$141	2026-04-30	Buy
Cayman Chemical	15413	(S)-MG115 ≥95%	133407-86-0	10mg	$252	2026-04-30	Buy

Product number	Packaging	Price	Buy
474780	5mg	$285	Buy
C6706	1mg	$99.3	Buy
15413	1mg	$57	Buy
15413	5mg	$141	Buy
15413	10mg	$252	Buy

MG-115 Chemical Properties,Uses,Production

Description

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (K_i = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.

Uses

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.[Cayman Chemical]

Uses

MG-115 is a compound that inhibits the chymotrypsin-like activity of the proteasome.

Definition

ChEBI: N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamic acid (phenylmethyl) ester is a peptide.

General Description

Potent reversible proteasome inhibitor (K_i = 21 nM and 35 nM for 20S and 26S proteasome, respectively).

Biochem/physiol Actions

Product does not compete with ATP.

References

1. involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome. imamura, t., haruta, t., takata, y., usui, i., iwata, m., ishihara, h., ishiki, m., ishibashi, o., ueno, e., sasaoka, t., kobayashi, m. j. biol. chem. (1998)

MG-115 Preparation Products And Raw materials

Raw materials

Preparation Products

MG-115 Suppliers

Global( 121)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Fine Biotech Co.，Ltd	18221172427; 18221172427	sale@fine-biotech.com	China	227	58
Shanghai Zhuyan Biotechnology Co., Ltd.	17521259211	17521259211@163.com	China	136	58
Alabiochem Tech.Co., Ltd.	512-58900862 400-0707518	sales@alabiochem.com	China	988	59
Nanjing Dulai Biotechnology Co., Ltd.	025-84699383-8003;025-846993838003-8003 18013301590	njduly@126.com	China	3293	55
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4773	55
ApexBio Technology LLC	+1-832-696-8203	info@apexbt.com	United States	477	60
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60

Supplier	Advantage
Shanghai Fine Biotech Co.，Ltd	58
Shanghai Zhuyan Biotechnology Co., Ltd.	58
Alabiochem Tech.Co., Ltd.	59
Nanjing Dulai Biotechnology Co., Ltd.	55
Guangzhou Isun Pharmaceutical Co., Ltd	55
ApexBio Technology LLC	60
Bide Pharmatech Ltd.	60
Sigma-Aldrich	80
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60

MG-115 Spectrum

MG-115(133407-86-0)MS MG-115(133407-86-0)¹HNMR

133407-86-0(MG-115)Related Search:

Trypsin trysin-chymotrypsin Basic protease MG-132 LACTACYSTIN

MG-115 Z-Leu-Leu-4,5-dehydro-Leu-aldehyde Z-Leu-Leu-Arg-AMC MG-262 GAMMA-SECRETASE INHIBITOR

Z-LLL-AMC Z-Leu-Leu-Glu-7-amino-4-trifluoromethylcoumarin Z-Leu-Leu-Leu-FMK N-Cbz-Leu-Leu-Glu beta-naphthylamide Z-Leu-Leu-Glu-AMC

1 mg Proteasome inhibitor MG-115Z-Leu-Leu-Nva-h(aldehyde) 5 mg Proteasome inhibitor MG-115Z-Leu-Leu-Nva-h(aldehyde) Proteasome inhibitor MG-115Z-Leu-Leu-Nva-h(aldehyde)

1of4

PROTEASOME INHIBITOR MG-115 N-CBZ-LEU-LEU-NORVALINAL MG-115 Z-LL-NVA-CHO Z-LEU-LEU-NVA-ALDEHYDE Z-LEU-LEU-NVA-CHO Z-LEU-LEU-NVA-H Z-LEU-LEU-NVA-H (ALDEHYDE) CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-NORVALINAL CARBOBENZOXY-L-LEUCYL-L-LEUCYL-NORVALINAL BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-NORVALINAL z-leu-leu-norvalinal N-carbobenzyloxy-Leu-Leu-norvalinal MG115, Z-LLnV Z-Leu-Leu-Norvalinal,MG115, Z-LLnV (S)-MG115 MG-115 (DMSO solution) Z-LLnV MG-115 - CAS 133407-86-0 - Calbiochem L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formylbutyl]- Benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-oxo-1-(((S)-1-oxopentan-2-yl)amino)pentan-2-yl)amino)-1-oxopentan-2-yl)carbamate MG-115, proteasome inhibitor Benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate 133407-86-0 C25H39N3O5 Inhibitors BioChemical Biochemicals and Reagents Application Index Cell Signaling Enzymes Proteasome, Calpain and Lysosomal Proteases Proteasomes Enzymes, Inhibitors, and Substrates Calpain and Lysosomal Proteases Proteasome Inhibitors Aldehydes and Substrates Application Index Bioactive Small Molecules Biochemicals and Reagents Building Blocks C13-C60 Calpain and Proteasome Inhibitors Carbonyl Compounds Cell Biology Cell Signaling and Neuroscience Cell Signaling Enzymes Chemical Synthesis Endoplasmic Reticulum Stress Enzymes Inhibitors Intracellular Protein Degradation Nitric Oxide and Cell Stress Organic Building Blocks Proteasome Proteasomes Z ProteasomeInhibitors