6-Cyano-2-naphthol
- CAS No.
- 52927-22-7
- Chemical Name:
- 6-Cyano-2-naphthol
- Synonyms
- 6-HYDROXY-2-NAPHTHONITRILE;6-CYANO-2-NAPHTHOL;2-Cyano-6-naphthol;CYANO(6-)-2-NAPTHOL;6-CYANO-2-NAPHTHALENOL;6-CYANO-2-NAPHTHOL 99%;Nafamostat Impurity 22;Nafamostat Impurity 25;6-Cyano-2-naphthol ,99%;Crisaborole Impurity 87
- CBNumber:
- CB6310673
- Molecular Formula:
- C11H7NO
- Molecular Weight:
- 169.18
- MDL Number:
- MFCD01863480
- MOL File:
- 52927-22-7.mol
- MSDS File:
- SDS
| Melting point | 165.5-170.5 °C (lit.) |
|---|---|
| Boiling point | 383.1±15.0 °C(Predicted) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Ethanol, Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 8.57±0.40(Predicted) |
| color | Pale Brown to Brown |
| InChI | InChI=1S/C11H7NO/c12-7-8-1-2-10-6-11(13)4-3-9(10)5-8/h1-6,13H |
| InChIKey | WKTNIBWKHNIPQR-UHFFFAOYSA-N |
| SMILES | C1=C2C(C=C(O)C=C2)=CC=C1C#N |
| CAS DataBase Reference | 52927-22-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29269090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
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6-Cyano-2-naphthol price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 530263 | 6-Cyano-2-naphthol 97% | 52927-22-7 | 25g | $373 | 2026-04-30 | Buy |
| TCI Chemical | H0995 | 6-Hydroxy-2-naphthonitrile >98.0%(GC)(T) | 52927-22-7 | 5g | $112 | 2026-04-30 | Buy |
| TRC | TRC-C981980-5G | 6-Cyano-2-naphthol | 52927-22-7 | 5g | $307 | 2026-06-03 | Buy |
| TRC | TRC-C981980-1G | 6-Cyano-2-naphthol | 52927-22-7 | 1g | $142 | 2026-06-03 | Buy |
| TRC | TRC-C981980-10G | 6-Cyano-2-naphthol | 52927-22-7 | 10g | $511 | 2026-06-03 | Buy |
6-Cyano-2-naphthol Chemical Properties, Uses, Production
Synthesis
In a 5000 mL three-necked flask, add 350 g of 6-hydroxy-2-naphthaldehyde (2.0 mol), 278 g of hydroxylamine hydrochloride (4.0 mol), and 3500 mL of dimethyl sulfoxide. Stir and heat to 100 °C, maintain the reaction temperature for 1 hour, then cool to room temperature. Mix the reaction solution with a large amount of water, and precipitate a solid with stirring. Filter, wash the filter cake with water to obtain a wet crude product, which is directly recrystallized from ethanol/water solution to give 237 g of a grayish-white purified product, yield 70%.
Chemical Properties
Brown Crystalline Solid. 6-Cyano-b-naphthol [52927-22-7], 6-cyano2-hydroxynaphthalene, 6-hydroxy-2-naphthoic acid nitrile, Mr 169.17, mp 166 – 167℃ This nitrile is used as an intermediate for the production of liquid crystals and monoamino-oxidase-inhibiting naphthalene-2-oxyalkylamines, which are used as antidepressive agents.
Uses
Intermediate of Nafamostat mesilate (N210000).
Uses
Reactant for:
- Palladium-catalyzed reduction
- Nickel-catalyzed cross-coupling reactions
- Palladium-catalyzed Heck reactions
General Description
6-Cyano-2-naphthol (6CN2) is an aromatic alcohol that can be synthesized from 6-bromo-2-naphthol. It is a superphotoacid with the ground state pKa* value of 8.4 and excited state pKavalue of 0.2, respectively. 6CN2 protonates PANI-ES (polyaniline emeraldine salt) to form PANI-EB (emeraldine base), which shows enhanced conductivity. The proton-transfer kinetics and photophysical behavior of 6CN2 have been investigated.
6-Cyano-2-naphthol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Xuanshuo Pharmaceutical Technology Co. LTD | 15269103900 | suchangzhou@shiningpharm.com | China | 383 | 58 |
| Hunan Furui Biopharma Technology Co., Ltd. | 15901640172，19275032510 15901640172 | sales03@hn-furui.com | China | 380 | 55 |
| Shanghai Goyic Pharmaceutical & Chemical Co., Ltd. | 021-50689757 15618953996 | sales@goyic.com | China | 310 | 58 |
| Shanghai Langruibang Pharmaceutical Technology Co., Ltd | 010-88755821 18612220856 | marketing@langrb.com | China | 419 | 58 |
| Shanghai Fuchunle Biotechnology Co., Ltd. | 15902102743 18121362927 | shelley@fortunabiotech.com | China | 108 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Latest Price from 6-Cyano-2-naphthol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-13 | 6-Cyano-2-naphthol
52927-22-7
|
1G | 99% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2024-04-22 | 6-Cyano-2-naphthol
52927-22-7
|
$1780.00 | 1Kg | 97 | 500 Kg | R&D Scientific Inc. | |
 |
2023-02-13 | 6-Hydroxy-2-naphthonitrile
52927-22-7
|
$10.00 | 1KG | 99% | 50MT | Hebei baicao biology science and technology co., ltd |
-
- 6-Cyano-2-naphthol
52927-22-7
- 99%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- 6-Cyano-2-naphthol
52927-22-7
- $1780.00
- 97
- R&D Scientific Inc.
-
- 6-Hydroxy-2-naphthonitrile
52927-22-7
- $10.00
- 99%
- Hebei baicao biology science and technology co., ltd
