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1-(4-Nitrophenyl)piperazine

1-(4-Nitrophenyl)piperazine Structure
1-(4-Nitrophenyl)piperazine structure
CAS No.
6269-89-2
Chemical Name:
1-(4-Nitrophenyl)piperazine
Synonyms
AKOS BBS-00003599;Piperazine-Ph-NO2;RARECHEM AH CK 0146;TIMTEC-BB SBB003475;LABOTEST-BB LT00076049;1-(P-NITROPHENYL)PIPERAZINE;1-(4-NITROPHENYL)PIPERAZINE;1-Nitro-4-piperazinobenzene;N-(4-NITROPHENYL)PIPERAZINE;N-(P-NITROPHENYL) PIPERAZINE
CBNumber:
CB6322746
Molecular Formula:
C10H13N3O2
Molecular Weight:
207.23
MDL Number:
MFCD00005961
MOL File:
6269-89-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:16:46
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1-(4-Nitrophenyl)piperazine Properties

Melting point 131-133 °C (lit.)
Boiling point 346.25°C (rough estimate)
Density 1.1933 (rough estimate)
refractive index 1.4830 (estimate)
storage temp. Storage temp. 2-8°C
form Crystalline Powder, Crystals and/or Chunks
pka 8.68±0.10(Predicted)
color White to beige to gray
InChI InChI=1S/C10H13N3O2/c14-13(15)10-3-1-9(2-4-10)12-7-5-11-6-8-12/h1-4,11H,5-8H2
InChIKey VWOJSRICSKDKAW-UHFFFAOYSA-N
SMILES N1(C2=CC=C([N+]([O-])=O)C=C2)CCNCC1
CAS DataBase Reference 6269-89-2(CAS DataBase Reference)
FDA UNII SE8XST987K
NIST Chemistry Reference N-p-nitrophenylpiperazine(6269-89-2)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  26-37/39-24/25-36
RIDADR  2811
WGK Germany  3
Hazard Note  Irritant
HazardClass  6.1
PackingGroup  III
HS Code  29335990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

1-(4-Nitrophenyl)piperazine price More Price(79)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 279773 1-(4-Nitrophenyl)piperazine 97% 6269-89-2 5g $84.8 2026-04-30 Buy
TCI Chemical N0694 1-(4-Nitrophenyl)piperazine >98.0%(T) 6269-89-2 5g $25 2026-04-30 Buy
TCI Chemical N0694 1-(4-Nitrophenyl)piperazine >98.0%(T) 6269-89-2 25g $69 2026-04-30 Buy
Usbiological 408201 1-(4-Nitrophenyl)piperazine 6269-89-2 1g $319 2026-06-03 Buy
Usbiological 408201 1-(4-Nitrophenyl)piperazine 6269-89-2 5g $410 2026-06-03 Buy
Product number Packaging Price Buy
279773 5g $84.8 Buy
N0694 5g $25 Buy
N0694 25g $69 Buy
408201 1g $319 Buy
408201 5g $410 Buy

1-(4-Nitrophenyl)piperazine Chemical Properties, Uses, Production

Chemical Properties

yellow to ochre powder

Uses

1-(4-Nitrophenyl)piperazine is a useful synthetic intermediate in the synthesis of Itraconazole (I937500); an orally active antimycotic structurally related to Ketoconazole. Also antifungal.

General Description

Inclusion interactions of 1-(4-nitrophenyl)piperazine with 4-sulfonatocalix[n]arenes were investigated by UV spectroscopy and fluorescence spectroscopy.

Synthesis

Piperazine

110-85-0

4-Chloronitrobenzene

100-00-5

1-(4-Nitrophenyl)piperazine

6269-89-2

A solution of 1-chloro-4-nitrobenzene (650 g, 4.140 mol) in diethylene glycol dimethyl ether (1 L) was slowly added dropwise to a solution of piperazine (2.84 Kg, 33.12 mol) in diethylene glycol dimethyl ether (500 mL) at 100 °C. The reaction mixture was stirred continuously at 100°C for 6 hours. Upon completion of the reaction, the mixture was cooled to 40-45 °C and water (5 L) was slowly added to quench the reaction. Subsequently, the mixture was warmed to room temperature and stirring was continued for 1 hour. The precipitated solid was collected by filtration, washed sequentially with water (1 L) and petroleum ether (500 mL), and dried to give 700 g (81% yield) of 4-nitrophenylpiperazine as a yellow solid. [TLC detection conditions: ethyl acetate:petroleum ether (3:7); Rf value: 0.70].

References

[1] Tetrahedron Letters, 1999, vol. 40, # 31, p. 5655 - 5659
[2] Organic Letters, 2016, vol. 18, # 20, p. 5272 - 5275
[3] Patent: WO2016/79536, 2016, A1. Location in patent: Page/Page column 34-35
[4] Patent: WO2017/203270, 2017, A1. Location in patent: Page/Page column 30; 33; 34
[5] Patent: WO2018/45106, 2018, A1. Location in patent: Paragraph 00133

1-(4-Nitrophenyl)piperazine Preparation Products And Raw materials

Raw materials

Piperazine 4-(4-Nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester Bis(2-chloroethyl)amine hydrochloride 4-Nitroaniline 4-Fluoronitrobenzene
4-Chloronitrobenzene 1-Bromo-4-nitrobenzene

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Preparation Products

4-(1-Acetylpiperazin-4-yl)phenol 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine 1-Methyl-4-(4-nitrophenyl)piperazine

1-(4-Nitrophenyl)piperazine Suppliers

Global Suppliers ( 301)
Supplier Tel Email Country ProdList Advantage
Huaian Jiamu Biotechnology Co., Ltd. 0517-83187139 18205232085 cai@jiamu-bio.com China 2999 58
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Supplier Advantage
Huaian Jiamu Biotechnology Co., Ltd. 58
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56

View Latest Price from 1-(4-Nitrophenyl)piperazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-(4-Nitrophenyl)piperazine pictures 2026-06-30 1-(4-Nitrophenyl)piperazine
6269-89-2
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
Palbociclib Impurity 14 pictures 2026-03-12 Palbociclib Impurity 14
6269-89-2
 10mg 98% 500mg ShenZhen H&D Pharmaceutical Technology Co., LTD
1-(4-Nitrophenyl)piperazine pictures 2021-07-13 1-(4-Nitrophenyl)piperazine
6269-89-2
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

1-(4-Nitrophenyl)piperazine Spectrum

1-(4-Nitrophenyl)piperazine(6269-89-2)1HNMR1-(4-Nitrophenyl)piperazine(6269-89-2)IR1-(4-Nitrophenyl)piperazine(6269-89-2)Raman

6269-89-2 (1-(4-Nitrophenyl)piperazine) Related Search:

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1-(3-NITROPHENYL)-PIPERAZINE Propiophenone 1-Acetyl-4-(4-nitrophenyl)piperazine 1-(4-METHOXYPHENYL)-4-(4-NITROPHENYL)PIPERAZINE 1-(3-Nitrophenyl)piperazin-2-one
4-Nitro-7-(1-piperazinyl)-2,1,3-benzoxadiazole 1-(4-HYDROXYPHENYL)-4-(4-NITROPHENYL)-PIPERAZINE 1-Methyl-4-(4-nitrophenyl)piperazine 1-(2,4-Dinitrophenyl)-piperazine HCl 1-Methyl-4-(3-nitrophenyl)piperazine
1-(2-Chloro-4-nitrophenyl)-piperazine 1-(2-NITROPHENYL)PIPERAZINE,1-(2-Nitrophenyl)piperazine ,98% BUTTPARK 83\09-70

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Piperazine-Ph-NO2 1-(4-nitrophenyl)piperazin-4-ium AKOS BBS-00003599 1-(P-NITROPHENYL)PIPERAZINE 1-NITRO-4-(1-PIPERAZINYL)BENZENE 1-(4-NITROPHENYL)PIPERAZINE 1-(4-NITRO-PHENYL)-PIPERAZINE DIHYDROCHLORIDE 1-(4-NITROPHENYL)PIPERAZINE HCL LABOTEST-BB LT00076049 1-(4-Nitrophenyl)piperazine 97% N-(P-NITROPHENYL) PIPERAZINE 1-(4-Nitrophenyl)piperazine, 98+% 1-Nitro-4-piperazinobenzene 1-Nitro-4-(piperazin-1-yl)benzene, 4-(Piperazin-1-yl)nitrobenzene Piperazine, 1-(4-nitrophenyl)- N-(4-NITROPHENYL)PIPERAZINE RARECHEM AH CK 0146 TIMTEC-BB SBB003475 1-(4-Nitrophenyl)piperazine> 4-Nitrophenyl piperazine, 97% 1-(4-Nitrophenyl)piperazine - [N93451] 6269-89-2 C10H14N3O2 C0H13N3O2 AMINE Building Blocks Heterocyclic Building Blocks Piperazines CHIRAL CHEMICALS Phenyls & Phenyl-Het Building Blocks Heterocyclic Building Blocks Piperazines Nitrogen cyclic compounds Piperidines, Piperidones, Piperazines pharmacetical Phenyls & Phenyl-Het Piperaizine API intermediates