HS-PEG7-CH2CH2N3
- CAS No.
- 2148986-06-3
- Chemical Name:
- HS-PEG7-CH2CH2N3
- Synonyms
- Azido-PEG7-Thiol;HS-PEG7-CH2CH2N3;23-azido-3,6,9,12,15,18,21-heptaoxatricosane-1-thiol
- CBNumber:
- CB63309441
- Molecular Formula:
- C16H33N3O7S
- Molecular Weight:
- 411.51
- MDL Number:
- MFCD34470049
- MOL File:
- 2148986-06-3.mol
HS-PEG7-CH2CH2N3 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA01K7D1 | 23-Azido-3,6,9,12,15,18,21-heptaoxatricosane-1-thiol min.90% | 2148986-06-3 | 250mg | $407 | 2026-05-30 | Buy |
| aablocks | AA01K7D1 | 23-Azido-3,6,9,12,15,18,21-heptaoxatricosane-1-thiol min.90% | 2148986-06-3 | 1g | $707 | 2026-05-30 | Buy |
| aablocks | AA01K7D1 | 23-Azido-3,6,9,12,15,18,21-heptaoxatricosane-1-thiol >96% | 2148986-06-3 | 5g | $3505 | 2026-05-30 | Buy |
| aablocks | AA01K7D1 | 23-Azido-3,6,9,12,15,18,21-heptaoxatricosane-1-thiol >96% | 2148986-06-3 | 10g | $5542 | 2026-05-30 | Buy |
| aablocks | AA01K7D1 | 23-Azido-3,6,9,12,15,18,21-heptaoxatricosane-1-thiol >96% | 2148986-06-3 | 25g | $10221 | 2026-05-30 | Buy |
HS-PEG7-CH2CH2N3 Chemical Properties, Uses, Production
Uses
HS-PEG7-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. HS-PEG7-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Biological Activity
HS-PEG7-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
PEGs
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
HS-PEG7-CH2CH2N3 Preparation Products And Raw materials
Raw materials
Preparation Products
HS-PEG7-CH2CH2N3 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80514535 19917294565 | et@chemextension.com | China | 5061 | 58 |
| Nanjing Bairuikang Biotechnology Co., Ltd. | 18168036974 | wangweicss@126.com | China | 1379 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 38900 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Yanfen Biochemical Technology Co.,LTD | 13611955358 15002190549 | yanfen2023@126.com | China | 2573 | 58 |
| Henan Mengtai Pharmaceutical Technology Co., Ltd | 17634413542 | 1959525201@qq.com | China | 9011 | 58 |
| Affinity Linkers Ltd. | 15841022315 15841022315 | sales@affinitytech.cn | China | 7039 | 58 |
| Shanghai meikai technology co., ltd | 021-68689288 15300790979 | info@mkbio.com.cn | China | 9755 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | info@chemextension.com | China | 42052 | 58 |
