BMS-986120
- CAS No.
- 1478712-37-6
- Chemical Name:
- BMS-986120
- Synonyms
- BMS-986120;BMS986120,BMS 986120;BMS-986120 1478712-37-6;2-methoxy-6-[6-methoxy-4-[[5-methyl-2-(4-morpholinyl)-4-thiazolyl]methoxy]-2-benzofuranyl]-imidazo[2,1-b]-1,3,4-thiadiazole;Imidazo[2,1-b]-1,3,4-thiadiazole, 2-methoxy-6-[6-methoxy-4-[[5-methyl-2-(4-morpholinyl)-4-thiazolyl]methoxy]-2-benzofuranyl]-
- CBNumber:
- CB63368644
- Molecular Formula:
- C23H23N5O5S2
- Molecular Weight:
- 513.59
- MDL Number:
- MFCD30532696
- MOL File:
- 1478712-37-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.57±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 4.87±0.10(Predicted) |
| form | A crystalline solid |
| color | White to off-white |
| FDA UNII | WDT28B7071 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS08,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H334-H317-H341-H361-H370-H335-H413 | |||||||||
| Precautionary statements | P201-P202-P260-P264-P270-P272-P273-P280-P284-P302+P352-P304+P341-P305+P351+P338-P310-P308+P313-P321-P362+P364-P333+P313-P342+P311-P363-P405-P501 | |||||||||
| NFPA 704 |
|
BMS-986120 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23497 | BMS 986120 ≥98% | 1478712-37-6 | 1mg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 23497 | BMS 986120 ≥98% | 1478712-37-6 | 5mg | $598 | 2026-04-30 | Buy |
| Cayman Chemical | 23497 | BMS 986120 ≥98% | 1478712-37-6 | 10mg | $1058 | 2026-04-30 | Buy |
| Biosynth | BB166502 | BMS 986120 | 1478712-37-6 | 1mg | $378.13 | 2026-06-04 | Buy |
| Biosynth | BB166502 | BMS 986120 | 1478712-37-6 | 2mg | $605 | 2026-06-04 | Buy |
BMS-986120 Chemical Properties, Uses, Production
Uses
BMS-986120 is a first-in-class oral and reversible protease-activated receptor 4 (PAR4) antagonist, with IC50s of 9.5 nM and 2.1 nM in human and monkey blood, respectively. BMS-986120 has potent and selective antiplatelet effects[1][2].
in vivo
In monkeys, BMS-986120 (1 mg/kg) does not inhibit PA induced by PAR1-AP, ADP and collagen, supporting selectivity. BMS-986120 (0.2, 0.5, 1 mg/kg) reduces TW by 35±5, 49±4, and 83±4%, respectively. Maximum KBT and MBT increases are only 2.2-fold and 1.8-fold, respectively[1].
IC 50
PAR1; PAR4
References
[1] Pancras C Wong, et al. Abstract 175: A Novel Orally-Active Small-Molecule Antagonist of the Platelet Protease-Activated Receptor-4, BMS-986120, Inhibits Arterial Thrombosis With Limited Impact on Hemostasis in Cynomolgus Monkeys. Stroke. 2018;47:A175.
[2] Wilson SJ, et al. PAR4 (Protease-Activated Receptor 4) Antagonism With BMS-986120 Inhibits Human Ex VivoThrombus Formation. Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):448-456. DOI:10.1161/ATVBAHA.117.310104
[3] Wong PC, et al. Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding. Sci Transl Med. 2017 Jan 4;9(371). DOI:10.1126/scitranslmed.aaf5294
BMS-986120 Preparation Products And Raw materials
Raw materials
Preparation Products
BMS-986120 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Tube Pharmaceutical Co., Ltd. | 021-54338626 18017892860 | sales@tubepharm.com | China | 2709 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| Shanghai zhigan biotechnology co., LTD | zhiqianbio@126.com | China | 19765 | 58 | |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
View Latest Price from BMS-986120 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | BMS-986120
1478712-37-6
|
$1080.00-2250.00 | 10g | TargetMol Chemicals Inc. |
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- BMS-986120
1478712-37-6
- $1080.00-2250.00
- TargetMol Chemicals Inc.
