BMS-986120 manufacturers
- BMS-986120
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- $1410.00
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2026-07-27
- CAS:1478712-37-6
- Purity:
- Supply Ability: 10g
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| | BMS-986120 Basic information |
| Product Name: | BMS-986120 | | Synonyms: | BMS-986120;BMS-986120 1478712-37-6;2-methoxy-6-[6-methoxy-4-[[5-methyl-2-(4-morpholinyl)-4-thiazolyl]methoxy]-2-benzofuranyl]-imidazo[2,1-b]-1,3,4-thiadiazole;Imidazo[2,1-b]-1,3,4-thiadiazole, 2-methoxy-6-[6-methoxy-4-[[5-methyl-2-(4-morpholinyl)-4-thiazolyl]methoxy]-2-benzofuranyl]-;BMS986120,BMS 986120 | | CAS: | 1478712-37-6 | | MF: | C23H23N5O5S2 | | MW: | 513.59 | | EINECS: | | | Product Categories: | | | Mol File: | 1478712-37-6.mol |  |
| | BMS-986120 Chemical Properties |
| density | 1.57±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 4.87±0.10(Predicted) | | form | A crystalline solid | | color | White to off-white |
| | BMS-986120 Usage And Synthesis |
| Uses | BMS-986120 is a first-in-class oral and reversible protease-activated receptor 4 (PAR4) antagonist, with IC50s of 9.5 nM and 2.1 nM in human and monkey blood, respectively. BMS-986120 has potent and selective antiplatelet effects[1][2]. | | in vivo | In monkeys, BMS-986120 (1 mg/kg) does not inhibit PA induced by PAR1-AP, ADP and collagen, supporting selectivity. BMS-986120 (0.2, 0.5, 1 mg/kg) reduces TW by 35±5, 49±4, and 83±4%, respectively. Maximum KBT and MBT increases are only 2.2-fold and 1.8-fold, respectively[1]. | | IC 50 | PAR1; PAR4 | | References | [1] Pancras C Wong, et al. Abstract 175: A Novel Orally-Active Small-Molecule Antagonist of the Platelet Protease-Activated Receptor-4, BMS-986120, Inhibits Arterial Thrombosis With Limited Impact on Hemostasis in Cynomolgus Monkeys. Stroke. 2018;47:A175.
[2] Wilson SJ, et al. PAR4 (Protease-Activated Receptor 4) Antagonism With BMS-986120 Inhibits Human Ex VivoThrombus Formation. Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):448-456. DOI:10.1161/ATVBAHA.117.310104
[3] Wong PC, et al. Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding. Sci Transl Med. 2017 Jan 4;9(371). DOI:10.1126/scitranslmed.aaf5294 |
| | BMS-986120 Preparation Products And Raw materials |
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