3-Bromo-4-methylpyridine
- CAS No.
- 3430-22-6
- Chemical Name:
- 3-Bromo-4-methylpyridine
- Synonyms
- Bromomethylpyridine;4-Meth;yihebio;3-BROMO-4-PICOLINE;3-Bromo-4-methylpyri;3-BROMO-4-METHYLPYRIDINE;4-METHYL-3-BROMOPYRIDINE;3-Bromo-4-methylpyridins;Pyridine, 3-broMo-4-Methyl-;3--4- MethylpyridinebroMide
- CBNumber:
- CB6338781
- Molecular Formula:
- C6H6BrN
- Molecular Weight:
- 172.02
- MDL Number:
- MFCD00082592
- MOL File:
- 3430-22-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Bromo-4-methylpyridine 96% | 548030 | 1g | $30.1 |
| 3-Bromo-4-methylpyridine 96% | 548030 | 5g | $77.7 |
| 3-Bromo-4-methylpyridine >98.0%(GC)(T) | B2831 | 1g | $19 |
| 3-Bromo-4-methylpyridine >98.0%(GC)(T) | B2831 | 5g | $30 |
| 3-Bromo-4-methylpyridine Asreported | 261559 | 10g | $305 |
| More product size | |||
| Boiling point | 199-200 °C(lit.) |
|---|---|
| Density | 1.549 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 175 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform, Methanol |
| pka | 3.54±0.18(Predicted) |
| form | Liquid |
| Specific Gravity | 1.549 |
| color | Clear colorless to yellow |
| BRN | 878354 |
| InChI | InChI=1S/C6H6BrN/c1-5-2-3-8-4-6(5)7/h2-4H,1H3 |
| InChIKey | GSQZOLXWFQQJHJ-UHFFFAOYSA-N |
| SMILES | C1=NC=CC(C)=C1Br |
| CAS DataBase Reference | 3430-22-6(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36-2636 | |||||||||
| RIDADR | Cool, dry,tightly closed | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Bromo-4-methylpyridine price More Price(87)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 548030 | 3-Bromo-4-methylpyridine 96% | 3430-22-6 | 1g | $30.1 | 2023-06-20 | Buy |
| Sigma-Aldrich | 548030 | 3-Bromo-4-methylpyridine 96% | 3430-22-6 | 5g | $77.7 | 2023-06-20 | Buy |
| TCI Chemical | B2831 | 3-Bromo-4-methylpyridine >98.0%(GC)(T) | 3430-22-6 | 1g | $19 | 2026-04-30 | Buy |
| TCI Chemical | B2831 | 3-Bromo-4-methylpyridine >98.0%(GC)(T) | 3430-22-6 | 5g | $30 | 2026-04-30 | Buy |
| Usbiological | 261559 | 3-Bromo-4-methylpyridine Asreported | 3430-22-6 | 10g | $305 | 2026-06-03 | Buy |
3-Bromo-4-methylpyridine Chemical Properties,Uses,Production
Chemical Properties
Clear Liquid
Uses
An intermediate of pyridinyl pyrrole compounds as proton pump inhibitors with improved gastric acid secretion suppressive activity
Uses
3-Bromo-4-methylpyridine may be used as a building block in the preparation of:
- substituted 4-(2,2-diphenylethyl)pyridine-N-oxides for use as potent phosphodiesterase type 4 (PDE4) inhibitors
- benzodiazepine site ligands bearing tricyclic pyridone moiety for human GABAA receptor
- a novel isomer of ascididemin
- 3-bromopyridine-4-carbonitrile
Synthesis
108-89-4
3430-22-6
The general procedure for the synthesis of 4-methyl-3-bromopyridine from 4-methylpyridine was as follows: 0.054 mol of 4-methylpyridine was added to a 60 mL constant pressure dropping funnel. Under nitrogen protection and stirring conditions at room temperature, it was slowly added dropwise to a mixture consisting of 0.07 mol AlCl3 and 0.01 mol potassium bromide, and the reaction mixture was stirred for 1 hour. A condensing unit was installed, heated to 120°C, and 0.07 mol of bromine was added slowly dropwise for about 1 hour dropwise. Heating and stirring were continued at 120°C for 26 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and slowly poured into crushed ice with stirring. The pH was adjusted to neutral by the addition of sodium hydroxide solution and stirred until completely dissolved. The aqueous layer was extracted with dichloromethane, the organic layers were combined and the solvent was recovered by steam distillation. The resulting oily product was purified by column chromatography (eluent ratio of VP petroleum ether: ethyl acetate = 6:1) to give 5.3 g of 3-bromo-4-methylpyridine in the form of a tan oil with a purity of 99.9% and a yield of 57%.
References
[1] Patent: CN106243022, 2016, A. Location in patent: Paragraph 0067-0069
[2] Patent: WO2014/97150, 2014, A1. Location in patent: Page/Page column 22-23
[3] Patent: US2005/80085, 2005, A1. Location in patent: Page/Page column 12
[4] Patent: US5294610, 1994, A
3-Bromo-4-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenyang TYSChem Co., Ltd. | +86-24-83607930 +8618640359690 | sales@honghuchem.com | China | 403 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501 | product@acmec-e.com | China | 33301 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177 | faithe@yan-xi.com | China | 5838 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-17732866630 | mina@chuanghaibio.com | China | 18114 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20111 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 877 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14032 | 58 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 809 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
View Lastest Price from 3-Bromo-4-methylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-10 | 3-Bromo-4-methylpyridine
3430-22-6
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 3-Bromo-4-methylpyridine
3430-22-6
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-11-18 | 3-Bromo-4-methylpyridine
3430-22-6
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited |
-
- 3-Bromo-4-methylpyridine
3430-22-6
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 3-Bromo-4-methylpyridine
3430-22-6
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3-Bromo-4-methylpyridine
3430-22-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
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