5-BROMO-2-CHLORO-BENZOYL CHLORIDE
- CAS No.
- 21900-52-7
- Chemical Name:
- 5-BROMO-2-CHLORO-BENZOYL CHLORIDE
- Synonyms
- Dapagliflozin Impurity 70;Dapagliflozin Impurity 55;Dapagliflozin Impurity N50;Dapagliflozin Impurity 70 CRS;5-BROMO-2-CHLORO-BENZOYL CHLORIDE;Benzoyl chloride, 5-bromo-2-chloro-
- CBNumber:
- CB6346795
- Molecular Formula:
- C7H3BrCl2O
- Molecular Weight:
- 253.91
- MDL Number:
- MFCD03208978
- MOL File:
- Mol file
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Bromo-2-chlorobenzoyl Chloride | 435330 | 250mg | $305 |
| 5-Bromo-2-chlorobenzoyl Chloride | 435330 | 500mg | $410 |
| 5-Bromo-2-chlorobenzoyl Chloride | TRC-B680522-500MG | 500mg | $103 |
| 5-Bromo-2-chlorobenzoyl Chloride | TRC-B680522-250MG | 250mg | $72 |
| 5-Bromo-2-chlorobenzoyl Chloride | TRC-B680522-1G | 1g | $170 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS07,GHS08,GHS05,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H334-H317-H314-H400-H302 |
| Precautionary statements | P261-P285-P304+P341-P342+P311-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501-P273-P391-P501-P264-P270-P301+P312-P330-P501 |
| RIDADR | UN1759 |
| HazardClass | 8 |
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
5-BROMO-2-CHLORO-BENZOYL CHLORIDE price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 435330 | 5-Bromo-2-chlorobenzoyl Chloride | 21900-52-7 | 250mg | $305 | 2026-06-03 | Buy |
| Usbiological | 435330 | 5-Bromo-2-chlorobenzoyl Chloride | 21900-52-7 | 500mg | $410 | 2026-06-03 | Buy |
| TRC | TRC-B680522-500MG | 5-Bromo-2-chlorobenzoyl Chloride | 21900-52-7 | 500mg | $103 | 2026-06-03 | Buy |
| TRC | TRC-B680522-250MG | 5-Bromo-2-chlorobenzoyl Chloride | 21900-52-7 | 250mg | $72 | 2026-06-03 | Buy |
| TRC | TRC-B680522-1G | 5-Bromo-2-chlorobenzoyl Chloride | 21900-52-7 | 1g | $170 | 2026-06-03 | Buy |
5-BROMO-2-CHLORO-BENZOYL CHLORIDE Chemical Properties,Uses,Production
Uses
5-Bromo-2-chlorobenzoyl Chloride is an intermediate in the synthesis of labelled and unlabelled isotopes of glucuronide metabolites of dapagliflozin. It also functions as an intermediate in the synthesis of dapagliflozin, a potent and selective hSGLT2 inhibitor.
Synthesis
21739-92-4
21900-52-7
Step 1. 5-Bromo-2-chlorobenzoic acid (100 g, 0.43 mol) was dissolved in 500 mL of dichloromethane and 1 g of pyridine was added as a catalyst. Thionyl chloride (60.5 g, 0.51 mol) was added slowly and dropwise at room temperature, followed by heating the reaction mixture to 40 °C and refluxing for 3.5 hours. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, dichloromethane was removed by distillation under reduced pressure to afford 104 g of 5-bromo-2-chlorobenzoyl chloride (yield: 97%), which can be used directly in the next step of the reaction without further purification.
References
[1] Patent: US2004/138439, 2004, A1. Location in patent: Page 18
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 4, p. 1236 - 1251
[3] Patent: WO2015/43511, 2015, A1. Location in patent: Paragraph 00227
[4] Patent: CN106892948, 2017, A. Location in patent: Paragraph 0269; 0270; 0271
[5] Patent: CN106316803, 2017, A. Location in patent: Paragraph 0013
5-BROMO-2-CHLORO-BENZOYL CHLORIDE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
5-BROMO-2-CHLORO-BENZOYL CHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShenZhen H&D Pharmaceutical Technology Co., LTD | +8618627948422 | sale@hdimpurity.com | China | 3681 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 9976 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8645 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49897 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
View Lastest Price from 5-BROMO-2-CHLORO-BENZOYL CHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-03-12 | Dapagliflozin Impurity 55 | 10mg | 0.98 | 5g | ShenZhen H&D Pharmaceutical Technology Co., LTD | ||
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2026-03-12 | Dapagliflozin Impurity 55 | 10mg | 0.98 | 10g | ShenZhen H&D Pharmaceutical Technology Co., LTD |
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- Dapagliflozin Impurity 55
- $0.00
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
-
- Dapagliflozin Impurity 55
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
