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Methyl oxalyl chloride

Methyl oxalyl chloride Structure
Methyl oxalyl chloride structure
CAS No.
5781-53-3
Chemical Name:
Methyl oxalyl chloride
Synonyms
Methyl 2-chloro-2-oxoacetate;METHYL CHLOROOXOACETATE;Methyl (Chlorocarbonyl)formate;MONO-METHYL OXALYL CHLORIDE;Methyl Oxalyl Choride;METHYL CHLOROGLYOXYLATE;Methyl chlorooxoacetate 96%;Oxalyl chloride MonoMethyl ester;Kelex-103;orocarbonyL
CBNumber:
CB0177645
Molecular Formula:
C3H3ClO3
Molecular Weight:
122.51
MDL Number:
MFCD00000705
MOL File:
5781-53-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:47:34
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Methyl oxalyl chloride Properties

Boiling point 118-120 °C (lit.)
Density 1.332 g/mL at 25 °C (lit.)
refractive index n20/D 1.419(lit.)
Flash point 116 °F
storage temp. Inert atmosphere,2-8°C
solubility Chloroform (Slightly), Ethyl Acetate
form Liquid
color Clear
Odor Acrid
Water Solubility Miscible with water.
Sensitive Moisture Sensitive
BRN 1071541
Stability Hygroscopic
InChI 1S/C3H3ClO3/c1-7-3(6)2(4)5/h1H3
InChIKey ZXUQEPZWVQIOJE-UHFFFAOYSA-N
SMILES COC(=O)C(Cl)=O
CAS DataBase Reference 5781-53-3(CAS DataBase Reference)
FDA UNII 42Z6XG83RQ
EPA Substance Registry System Acetic acid, chlorooxo-, methyl ester (5781-53-3)
UNSPSC Code 12352101
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Corrosion (GHS05)Exclamation Mark (GHS07)
GHS02,GHS05,GHS07
Signal word  Danger
Hazard statements  H226-H314-H335
Precautionary statements  P210-P233-P240-P280-P303+P361+P353-P305+P351+P338
target organs Respiratory system
PPE Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes  C,F
Risk Statements  34-37-10-36-14
Safety Statements  26-36/37/39-45-16
RIDADR  UN 2920 8/PG 2
WGK Germany  3
F  9-21
TSCA  TSCA listed
HazardClass  8
PackingGroup  II
HS Code  29171900
Storage Class 3 - Flammable liquids
Hazard Classifications Eye Dam. 1
Flam. Liq. 3
Skin Corr. 1B
STOT SE 3
REACH Registrations Active
NFPA 704
2
3 0
W

Methyl oxalyl chloride price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 151440 Methyl chlorooxoacetate 96% 5781-53-3 5g $61.5 2026-04-30 Buy
Sigma-Aldrich 151440 Methyl chlorooxoacetate 96% 5781-53-3 10g $102 2026-04-30 Buy
TCI Chemical C1561 Methyl Chloroglyoxylate >98.0%(GC)(T) 5781-53-3 25g $94 2026-04-30 Buy
TCI Chemical C1561 Methyl Chloroglyoxylate >98.0%(GC)(T) 5781-53-3 250g $371 2026-04-30 Buy
Usbiological 283744 Methyl chlorooxoacetate Asreported 5781-53-3 10g $389 2026-06-03 Buy
Product number Packaging Price Buy
151440 5g $61.5 Buy
151440 10g $102 Buy
C1561 25g $94 Buy
C1561 250g $371 Buy
283744 10g $389 Buy

Methyl oxalyl chloride Chemical Properties, Uses, Production

Synthesis

Dilute oxaloyl chloride (0.51 mL, 6 mmol) with CH2Cl2 (1 mL). Cool to 0°C. While stirring, add dropwise a solution of alcohol (3 mmol) in CH2Cl2 (1 mL). Stir the mixture for 20 minutes. Then heat to room temperature for 2 hours. Evaporate the solvent and excess oxaloyl chloride under vacuum to obtain the target compound, oxaloyl chloride monomethyl ester. The synthetic route is shown in Figure

Synthetic Route of METHYL OXALYL CHLORIDE

Figure: Synthetic Route of METHYL OXALYL CHLORIDE

Uses

Methyl oxalyl chloride is an important organic intermediate (building block) to synthetize substituted methyl oxalyl products. It can be used for regioselective synthesis of fused coumarins, cyclization to form substituted isoxazoles and heterocycles, intramolecular Wittig reactions, silyl enol ether acylation, and iron-mediated cleavage of C-C bonds.

Chemical Properties

CLEAR LIQUID

Uses

Methyl oxalyl chloride is used as a synthetic reagent. It serves as a reagent in the synthesis of fused coumarins, substituted isoxazoles and heterocycles. Further, it is used in intramolecular Wittig reactions, and iron-mediated cleavage of C-C bonds.

Uses

Reactant involved in:

  • Regioselective synthesis of fused coumarins
  • Cyclization to form substituted isoxazoles and heterocycles
  • Intramolecular Wittig reactions
  • Silyl enol ether acylation
  • Iron-mediated cleavage of C-C bonds

reaction suitability

reagent type: oxidant

Methyl oxalyl chloride synthesis

67-56-1
79-37-8
5781-53-3
Synthesis of Methyl oxalyl chloride from Methanol and Oxalyl chloride

Methyl oxalyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

SVFHMQGYXMIBND-UHFFFAOYSA-N 5-Bromo-2-chloro-benzoyl chloride Methyl indolyl-3-glyoxylate Ethyl 4-fluoro-2-methylbenzoylformate Methyl 5-methylthiophene-2-glyoxylate
Methyl 2-(4-ethoxyphenyl)-2-oxoacetate Methyl 2-(methylanilino)-2-oxoacetate methyl 2-(4-chlorophenyl)-2-oxoacetate 3,7-Dichloro-1-(2-propoxyethyl)-1H,2H-pyrido-[3,4-b]pyrazin-2-one

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Methyl oxalyl chloride Suppliers

Global Suppliers ( 307)
Supplier Tel Email Country ProdList Advantage
HANGZHOU KINSOCHEM PHARMA CO.,LTD 0571-56950601,56950602 15957107654 951594434@qq.com China 49 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Suzhou Highfine Biotech Co., Ltd 0512-69209928 18796809688 zhouyingxiang@highfine.com China 472 75
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Supplier Advantage
HANGZHOU KINSOCHEM PHARMA CO.,LTD 55
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
Suzhou Highfine Biotech Co., Ltd 75
Beijing Ouhe Technology Co., Ltd 60

Related articles

  • What is Methyl Oxalyl Chloride?
  • Methyl oxalyl chloride is an important organic intermediate (building block) to synthetize substituted methyl oxalyl products.....
  • Feb 18,2020

View Latest Price from Methyl oxalyl chloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
METHYL OXALYL CHLORIDE pictures 2026-08-08 METHYL OXALYL CHLORIDE
5781-53-3
 1kg 99.0%min 10000kg Hangzhou ICH Biofarm Co., Ltd
METHYL OXALYL CHLORIDE pictures 2026-03-20 METHYL OXALYL CHLORIDE
5781-53-3
 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd
Methyl Oxalyl Choride pictures 2025-05-26 Methyl Oxalyl Choride
5781-53-3
 $6.00 1kg 0.99 10000 Hebei Fengjia New Material Co., Ltd

Methyl oxalyl chloride Spectrum

METHYL OXALYL CHLORIDE(5781-53-3)1HNMRMETHYL OXALYL CHLORIDE(5781-53-3)IRMETHYL OXALYL CHLORIDE(5781-53-3)RamanMETHYL OXALYL CHLORIDE(5781-53-3)FT-IR

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CHLOROGLYOXYLIC ACID METHYL ESTER METHYL CHLOROFORMYLFORMATE METHYL CHLOROGLYOXALATE METHYL CHLOROGLYOXYLATE Acetic acid,2-chloro-2-oxo-, Methyl ester Grass single Methyl chloride Acetic acid, chlorooxo-, methyl ester Methyl chloroglyoxylate for synthesis Methyleoxalyl chloride chlorogyloxylicacidmethylester chlorooxo-aceticacimethylester METHYL CHLOROOXOACETATE,96% Methyloxalylchloride,97% Oxalic acid monomethyl ester chloride Methyl chloroglyoxalate, Methyl oxalyl chloride, Monomethyl oxalyl chloride Methyl chloroglyoxalate, Methyl oxalyl chloride (Oxalic acid 1-methyl) chloride 2-Chloroglyoxylic acid methyl ester 2-Oxo-2-chloroacetic acid methyl ester Chlorooxoacetic acid methyl ester Oxochloroacetic acid methyl ester Methyl oxalyl chloride ,98% Methyl chlorooxoacetate ,97% Chloroglyoxylic Acid Methyl Ester Methyl Oxalyl Chloride orocarbonyL Methyl Chloroglyoxylate > Chloroglyoxylic Acid Methyl Ester,>98% Kelex-103 Foscarbidopa Impurity 9 Methyl oxalyl chloride 98% Oxaloyl chloride monomethyl ester Methyl (Chlorocarbonyl)formate Methyl 2-chloro-2-oxoacetate Methyl Oxalyl Choride Methyl chlorooxoacetate 96% METHYL CHLOROOXOACETATE MONO-METHYL OXALYL CHLORIDE Oxalyl chloride MonoMethyl ester Methyl oxalyl chloride 5781-53-3 C3H3ClO3 ClCOCOOCH3 ACID CHLORIDE Synthetic Reagents Others Oxidation Organics