(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
- CAS No.
- 461432-22-4
- Chemical Name:
- (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
- Synonyms
- Dapagliflozin iMpurity A;Dapagliflozin-15;Dapagliflozin Impurity 18;Dapagliflozin Intermediate I;Dapagliflozin Bromomethanone;5-broMo-2-chloro-4'-ethoxybenzophenone;(5-broMo-2-chlorophenyl)(4-ethoxyphenyl)-;5-bromo-2-chloro-4’-ethoxydiphenylmethanone;5-Bromo-2-ChIorophenyI 4-Ethoxypheny Methanone;(5-Bromo-2-chlorophenyl)(4-oxophenyl)methanone
- CBNumber:
- CB11509853
- Molecular Formula:
- C15H12BrClO2
- Molecular Weight:
- 339.61
- MDL Number:
- MFCD11044417
- MOL File:
- 461432-22-4.mol
- MSDS File:
- SDS
| Boiling point | 439.2±40.0 °C(Predicted) |
|---|---|
| Density | 1.437 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Low-Melting Solid |
| color | Off-White to Pale Yellow |
| InChI | InChI=1S/C15H12BrClO2/c1-2-19-12-6-3-10(4-7-12)15(18)13-9-11(16)5-8-14(13)17/h3-9H,2H2,1H3 |
| InChIKey | OEURLNJEQCLGPS-UHFFFAOYSA-N |
| SMILES | C(C1=CC(Br)=CC=C1Cl)(C1=CC=C(OCC)C=C1)=O |
| CAS DataBase Reference | 461432-22-4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P261-P305+P351+P338 |
| REACH Registrations | Active |
(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 435339 | (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone | 461432-22-4 | 250mg | $305 | 2026-06-03 | Buy |
| Usbiological | 435339 | (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone | 461432-22-4 | 1g | $389 | 2026-06-03 | Buy |
| TRC | TRC-B680542-5G | (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone | 461432-22-4 | 5g | $177 | 2026-06-03 | Buy |
| TRC | TRC-B680542-250MG | (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone | 461432-22-4 | 250mg | $70 | 2026-06-03 | Buy |
| TRC | TRC-B680542-1G | (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone | 461432-22-4 | 1g | $83 | 2026-06-03 | Buy |
(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone Chemical Properties, Uses, Production
Uses
(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone is an intermediate used in the improved synthesis of Dapagliflozin, a novel selective sodium-glucose co-transporter type II (SGLT2) inhibitor.
Synthesis
21900-52-7
103-73-1
461432-22-4
Under the protection of nitrogen, 2.1 g of tert-butyldimethylchlorosilane prepared in step 1) was mixed with 5-bromo-2-chlorobenzoyl chloride in anhydrous dichloromethane and stirred for 30 min at 0 to 10 °C. Subsequently, 1.2 mol of phenethyl ether and 1.1 mol of ferric chloride were sequentially added to the reaction system, and the reaction temperature was maintained at 14.7 °C, and the reaction continued to be stirred for 5 hours. After completion of the reaction, the reaction mixture was quenched by pouring it into ice water, extracted with dichloromethane, the organic phase was washed with water, and 31 g of 5-bromo-2-chloro-4'-ethoxy benzophenone (intermediate of dagliflozin) was obtained after concentration in 91.4% yield and 99.49% purity.
References
[1] Patent: CN107200683, 2017, A. Location in patent: Paragraph 0029; 0035; 0039; 0043; 0047
[2] Patent: CN107417515, 2017, A. Location in patent: Paragraph 0030; 0032; 0034; 0036; 0038; 0040
[3] Patent: CN103739581, 2016, B. Location in patent: Paragraph 0228; 0229
[4] Patent: WO2012/25857, 2012, A1. Location in patent: Page/Page column 20
[5] Patent: CN106316803, 2017, A. Location in patent: Paragraph 0014
(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong Xiaozhu Biopharmaceutical Co., Ltd. | 18015606981 | xmwang@xiaozhubiopharma.com | China | 149 | 58 |
| Suzhou Xiaoli Material Technology Co., Ltd. | 0512-87815088 18015562287 | xmwang@xiaolitech.com | China | 66 | 58 |
| Xiamen Ruiyuxin Biotechnology Co., Ltd | 0598-5501589 15392323620 | zmy@welikepharma.com | China | 97 | 58 |
| EVERSHINE CHEMICAL CO., LIMITED | 17185714011 | 3506894070@qq.com | China | 119 | 58 |
| Anhui Dexinjia Biopharm Co., Ltd | 0531-82375893 15553111391 | phoebe@jndxj.com | China | 285 | 58 |
| Anqing CHICO Pharmaceutical Co., Ltd. | 18061456370 | david@chicopharm.com | China | 461 | 58 |
| Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd. | 21-54820552 17702105771 | 188738128@qq.com | China | 300 | 66 |
| Beijing Huikang Boyuan Chemical Tech Co., Ltd | 010-68862197 13810598707;13810598707 | sales@huikangchem.com | China | 97 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Latest Price from (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
461432-22-4
|
$5.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-08 | (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
461432-22-4
|
1KG | 99% | 500 | Hangzhou ICH Biofarm Co., Ltd | ||
 |
2026-07-30 | (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
461432-22-4
|
$150.00-200.00 | 1kg | 99% | 5000kg per month | Anhui Dexinjia Biopharm Co., Ltd |
-
- (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
461432-22-4
- $5.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
461432-22-4
- 99%
- Hangzhou ICH Biofarm Co., Ltd
-
- (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
461432-22-4
- $150.00-200.00
- 99%
- Anhui Dexinjia Biopharm Co., Ltd
461432-22-4 ((5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone) Related Search:
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