5-Bromo-quinolin-8-ylamine
- CAS No.
- 53472-18-7
- Chemical Name:
- 5-Bromo-quinolin-8-ylamine
- Synonyms
- 5-BROMOQUINOLIN-8-AMINE;AKOS B015996;AKOS MSC-0726;ART-CHEM-BB B015996;TIMTEC-BB SBB001595;5-BROMO-8-QUINOLINAMINE;5-BROMO-8-AMINOQUINOLINE;8-Amino-5-bromoquinoline;(5-bromo-8-quinolyl)amine;8-Quinolinamine, 5-bromo-
- CBNumber:
- CB6349019
- Molecular Formula:
- C9H7BrN2
- Molecular Weight:
- 223.07
- MDL Number:
- MFCD01571832
- MOL File:
- 53472-18-7.mol
- MSDS File:
- SDS
| Melting point | 109-110 °C |
|---|---|
| Boiling point | 353.3±27.0 °C(Predicted) |
| Density | 1.649±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 3.02±0.12(Predicted) |
| Appearance | Yellow to brown Solid |
| CAS DataBase Reference | 53472-18-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H332-H315-H302-H312-H335 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P261-P271-P304+P340-P312 |
5-Bromo-quinolin-8-ylamine price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FB127216 | 5-Bromoquinolin-8-amine | 53472-18-7 | 25g | $687.5 | 2026-06-04 | Buy |
| Biosynth | FB127216 | 5-Bromoquinolin-8-amine | 53472-18-7 | 50g | $1031.5 | 2026-06-04 | Buy |
| Biosynth | FB127216 | 5-Bromoquinolin-8-amine | 53472-18-7 | 100g | $1513 | 2026-06-04 | Buy |
| Biosynth | FB127216 | 5-Bromoquinolin-8-amine | 53472-18-7 | 250g | $3025 | 2026-06-04 | Buy |
| Biosynth | FB127216 | 5-Bromoquinolin-8-amine | 53472-18-7 | 500g | $5500 | 2026-06-04 | Buy |
5-Bromo-quinolin-8-ylamine Chemical Properties, Uses, Production
Synthesis
578-66-5
53472-18-7
4.1.16 Synthesis of 5-bromo-8-aminoquinoline (21): 8-aminoquinoline (1.0 g, 6.94 mmol) was dissolved in 46.0 mL of acetonitrile, and N-bromosuccinimide (NBS, 605 mg, 3.40 mmol for the first portion) was added in batches. The reaction mixture was stirred at 25 °C for 15 min and then the second portion of NBS (667 mg, 3.75 mmol) was added. Stirring of the reaction mixture was continued at 25°C. After completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was dissolved in ethyl acetate (EtOAc) and washed with deionized water (3 x 50 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by silica gel fast column chromatography (eluent: petroleum ether solution of 10% ethyl acetate) to afford 5-bromoquinolin-8-amine as a yellow amorphous solid in 51% yield.1H NMR (300 MHz, CDCl3) δ 8.76 (d, 1H, J=6.0 Hz), 8.43 (d, 1H, J=9.0 Hz), 7.56 (d, 1H. J=12.0 Hz), 7.48 (q, 1H, J=3.0 Hz), 6.80 (d, 1H, J=6.0 Hz); ESI-MS m/z 222.9 [M+H]+.
References
[1] European Journal of Medicinal Chemistry, 2019, p. 290 - 320
[2] Patent: EP3401309, 2018, A1. Location in patent: Paragraph 0859
[3] Patent: WO2010/30722, 2010, A1. Location in patent: Page/Page column 46
[4] Patent: WO2016/77240, 2016, A2. Location in patent: Page/Page column 90; 104
5-Bromo-quinolin-8-ylamine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4368 | 65 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1998 | 58 |
| Shanghai potentpharm CO.,Ltd | 13524892556 | sales-cn@potentpharm.com | China | 1011 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
