4-Amino-3-bromoquinoline
- CAS No.
- 36825-36-2
- Chemical Name:
- 4-Amino-3-bromoquinoline
- Synonyms
- 3-broMoquinolin-4-aMine;3-Bromo-4-quinolinamine;3-bromo-4-aminoquinoline;4-AMINO-3-BROMOQUINOLINE;4-Quinolinamine, 3-bromo-;3-BROMO-QUINOLIN-4-YLAMINE;4-Amino-3-bromoquinoline ISO 9001：2015 REACH
- CBNumber:
- CB7374863
- Molecular Formula:
- C9H7BrN2
- Molecular Weight:
- 223.07
- MDL Number:
- MFCD00234502
- MOL File:
- 36825-36-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 203°C |
|---|---|
| Boiling point | 346.8±27.0 °C(Predicted) |
| Density | 1.6051 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 6.53±0.50(Predicted) |
| form | solid |
| Appearance | Off-white to light yellow Solid |
| InChI | 1S/C9H7BrN2/c10-7-5-12-8-4-2-1-3-6(8)9(7)11/h1-5H,(H2,11,12) |
| InChIKey | TYGUEEGQSYNEHB-UHFFFAOYSA-N |
| SMILES | NC1=C(Br)C=NC2=C1C=CC=C2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Risk Statements | 41 |
| Safety Statements | 26-39 |
| WGK Germany | WGK 3 |
| HS Code | 2933499090 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 |
4-Amino-3-bromoquinoline price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | BBO000629 | 4-Amino-3-bromoquinoline | 1 g | $454 | 2026-04-30 | Buy | |
| Activate Scientific | AS30588 | 4-Amino-3-bromoquinoline 95% | 36825-36-2 | 1g | $67 | 2026-06-04 | Buy |
| Apolloscientific | OR309338 | 4-Amino-3-bromoquinoline ≥95% | 36825-36-2 | 1g | $453 | 2026-06-04 | Buy |
| Activate Scientific | AS30588 | 4-Amino-3-bromoquinoline 95% | 36825-36-2 | 5g | $198 | 2026-06-04 | Buy |
| Apolloscientific | OR309338 | 4-Amino-3-bromoquinoline ≥95% | 36825-36-2 | 5g | $1205 | 2026-06-04 | Buy |
4-Amino-3-bromoquinoline Chemical Properties, Uses, Production
Uses
4-Amino-3-bromoquinoline is a useful research intermediate for the preparation of aminoquinolines.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 43, p. 4667, 2000 DOI: 10.1021/jm0002073
Synthesis
578-68-7
36825-36-2
The general procedure for the synthesis of 3-bromo-4-aminoquinoline from 4-aminoquinoline was as follows: 34.6 g (240 mmol) of 4-aminoquinoline was added to a reaction flask and dissolved in 76 mL of glacial acetic acid. The reaction mixture was cooled to 0 °C and 42.2 g (264 mmol) of liquid bromine dissolved in 100 mL of glacial acetic acid was slowly added dropwise under stirring conditions. During the dropwise addition, a solid precipitate was observed to be generated, which was due to the low solubility of the product in acetic acid. After the dropwise addition was completed, the reaction mixture continued to be stirred at room temperature for 30 minutes. Subsequently, 1520 mL of ether was added to the reaction mixture and the precipitate was collected by filtration. The resulting precipitate was dissolved in 800 mL of water (most of the product was soluble in cold water and the remainder could be dissolved by heating to reflux). The solution was adjusted to alkaline with 1N aqueous sodium hydroxide, at which point a large amount of solid precipitated. The precipitate was collected by filtration, washed with 800 mL of water and dried in a vacuum oven under reduced pressure to give 44.16 g of 3-bromo-4-aminoquinoline, the product was off-white in 82% yield. The melting point was 200.6~201.7℃.
References
[1] Journal of Medicinal Chemistry, 2000, vol. 43, # 24, p. 4667 - 4677
[2] Patent: CN105461623, 2016, A. Location in patent: Paragraph 0039-0041
[3] Journal fuer Praktische Chemie (Leipzig), 1894, vol. <2> 50, p. 239
4-Amino-3-bromoquinoline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1998 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Shanghai ChriChem Co., Ltd. | 021-54880687 | China | 510 | 55 |
View Latest Price from 4-Amino-3-bromoquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 4-Amino-3-bromoquinoline
36825-36-2
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2019-12-31 | 4-Amino-3-bromoquinoline
36825-36-2
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 4-Amino-3-bromoquinoline
36825-36-2
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4-Amino-3-bromoquinoline
36825-36-2
- $1.00
- 99%
- Career Henan Chemical Co
