N-Cyclohexylmaleimide
- CAS No.
- 1631-25-0
- Chemical Name:
- N-Cyclohexylmaleimide
- Synonyms
- 1-CYCLOHEXYL-1H-PYRROLE-2,5-DIONE;AKOS MSC-0038;ASISCHEM D13289;Cyclohexylmaleimide;TIMTEC-BB SBB005910;N-CYCLOHEXYLMALEIMIDE;N-Cyclohexylmaleinimide;N-CYCLOHEXYLMALEIC IMIDE;N-Cyclohexylmaleimide 97%;N-Cyclohexylmaleimide >
- CBNumber:
- CB7215207
- Molecular Formula:
- C10H13NO2
- Molecular Weight:
- 179.22
- MDL Number:
- MFCD00043904
- MOL File:
- 1631-25-0.mol
- MSDS File:
- SDS
| Melting point | 89-91 °C (lit.) |
|---|---|
| Boiling point | 132 °C / 17mmHg |
| Density | 1.226±0.06 g/cm3(Predicted) |
| vapor pressure | 80Pa at 25℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Insoluble in water |
| pka | -2.26±0.20(Predicted) |
| form | powder to lump |
| color | White to Almost white |
| Water Solubility | 260mg/L at 25℃ |
| InChI | InChI=1S/C10H13NO2/c12-9-6-7-10(13)11(9)8-4-2-1-3-5-8/h6-8H,1-5H2 |
| InChIKey | BQTPKSBXMONSJI-UHFFFAOYSA-N |
| SMILES | N1(C2CCCCC2)C(=O)C=CC1=O |
| LogP | 2.57 at 23℃ |
| CAS DataBase Reference | 1631-25-0(CAS DataBase Reference) |
| FDA UNII | 3BD6JKD4Q7 |
| EPA Substance Registry System | 1H-Pyrrole-2,5-dione, 1-cyclohexyl- (1631-25-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H317-H319-H335-H410 | |||||||||
| Precautionary statements | P261-P273-P280-P301+P310-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29251900 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Acute Tox. 3 Oral Aquatic Acute 1 Aquatic Chronic 3 Eye Irrit. 2 Skin Irrit. 2 Skin Sens. 1A STOT SE 3 |
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| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
N-Cyclohexylmaleimide price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 381543 | N-Cyclohexylmaleimide 97% | 1631-25-0 | 5g | $162 | 2026-04-30 | Buy |
| TCI Chemical | C1044 | N-Cyclohexylmaleimide >98.0%(GC) | 1631-25-0 | 25g | $37 | 2026-04-30 | Buy |
| TCI Chemical | C1044 | N-Cyclohexylmaleimide >98.0%(GC) | 1631-25-0 | 100g | $90 | 2026-04-30 | Buy |
| Apolloscientific | OR7279 | N-Cyclohexylmaleimide 98% | 1631-25-0 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR7279 | N-Cyclohexylmaleimide 98% | 1631-25-0 | 25g | $37 | 2026-06-04 | Buy |
N-Cyclohexylmaleimide Chemical Properties,Uses,Production
Uses
N-Cyclohexylmaleimide (CHMI, NCMI) may be used for the preparation of hyperbranched copolymers of p-(chloromethyl)styrene (CMS) and NCMI, via atom transfer radical copolymerization reaction.
Synthesis Reference(s)
Synthetic Communications, 20, p. 1607, 1990 DOI: 10.1080/00397919008053079
General Description
N-Cyclohexylmaleimide (CHMI, NCMI) is a cyclic imide. Diels-Alder reactions of 9-hydroxymethylanthracene with CHMI catalyzed by hydrophobic nanospace confined within the self-assembled Pd6 open cage bearing triimidazole walls have been reported. It undergoes Diels-Alder reactions with various aromatic hydrocarbons promoted by self-assembled coordination cage. This cage acts as nanometer-sized molecular flask and hence promotes this reaction. CHMI is reported to undergo radical polymerization readily under various polymerization conditions to afford poly(CHMI), having excellent thermal stability.
Flammability and Explosibility
Not classified
Synthesis
108-31-6
108-91-8
1631-25-0
1. In a 100 L reactor equipped with a thermometer, water separator, cooler and stirrer, 40 kg of xylene was added as solvent. Subsequently, 2 kg of silica gel as carrier, 2 kg (17.3 mol) o-phosphoric acid, 30 g (0.19 mol) of zinc acetate and 30 g (0.14 mol) of 2,4-dimethyl-6-tert-butylphenol were added sequentially. 200 g (1.96 mol) of triethylamine was added to neutralize the reaction system, followed by the slow addition of 4 kg (43.0 mol) of cyclohexylamine over 5 min to form the amine salt. 2. 4.4kg of maleic anhydride was added to the reactor over 5 minutes. The reaction temperature was maintained at 140°C and the resulting water was removed by azeotropic distillation along with xylene through a water separator. The reaction was maintained at this temperature for 3 hours. 3. After 3 hours of reaction, an additional 200g of maleic anhydride was added and the reaction was continued for another 3 hours. Upon completion of the reaction, the reaction mixture was cooled to 30°C and the catalyst layer was removed by layer separation. 4. The xylene solution layer was transferred to a neutralization tank, 500 g of 5% aqueous sodium carbonate solution was added, stirred for 20 minutes and then allowed to stand for 20 minutes to stratify the solution. Separate and discard the aqueous layer. 5. Add 500g of water to the organic layer, stir for 20 minutes and leave for 20 minutes, separate again and discard the aqueous layer. 6. The purified organic layer was transferred to a concentration tank and gradually heated under reduced pressure to 50°C, 100°C and finally distilled at 20°C to remove xylene. After complete evaporation of the solvent, 7.1 kg of light white solid product was obtained. 7. The purity of the product N-cyclohexylmaleimide was 98% by liquid chromatography analysis, based on a 97% yield of cyclohexylamine.
References
[1] Patent: EP2311804, 2011, A2. Location in patent: Page/Page column 7-8
[2] Patent: US2011/124882, 2011, A1. Location in patent: Page/Page column 5
[3] Patent: JP6273389, 2018, B1. Location in patent: Paragraph 0044-0054
[4] Patent: JP6336192, 2018, B1. Location in patent: Paragraph 0054; 0055; 0057; 0059; 0060; 0061-0066
[5] Molecules, 2018, vol. 23, # 11,
N-Cyclohexylmaleimide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai tuojing new materials technology co., ltd. | 021-56389801-802 13122713670 | tchemtech@163.com | China | 19 | 58 |
| Guangzhou Shanghe Chemical Technology Co., Ltd | 13352869970 13352869970 | 272907493@qq.com | China | 1122 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Suzhou Highfine Biotech Co., Ltd | 0512-69209928 18796809688 | zhouyingxiang@highfine.com | China | 472 | 75 |
View Lastest Price from N-Cyclohexylmaleimide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | N-Cyclohexylmaleimide
1631-25-0
|
$10.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2019-07-06 | N-Cyclohexylmaleimide
1631-25-0
|
$1.00 | 1KG | 98% | 1 | Career Henan Chemical Co |
-
- N-Cyclohexylmaleimide
1631-25-0
- $10.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- N-Cyclohexylmaleimide
1631-25-0
- $1.00
- 98%
- Career Henan Chemical Co
