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1,3-Dimethyl-5-pyrazolone

1,3-Dimethyl-5-pyrazolone structure

CAS No.: 2749-59-9

Chemical Name:: 1,3-Dimethyl-5-pyrazolone

Synonyms: 2,5-Dimethyl-2,4-dihydro-3H-pyrazol-3-one;1,3-dimethyl-2-pyrazolin-5-one;3H-PYRAZOL-3-ONE, 2,4-DIHYDRO-2,5-DIMETHYL-;NSC 304;BUTTPARK 82\11-61;1,3-Dimethyl-5-pyraz;1,3-DIMETHYLPYRAZOLONE;1,3-diMethyl-5-pyrozolone;1,3-DIMETHYL-5-PYRAZOLONE;1,3-Dimethyl-5-pyrazolinone

CBNumber:: CB6371683

Molecular Formula:: C5H8N2O

Molecular Weight:: 112.13

MDL Number:: MFCD00067008

MOL File:: 2749-59-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:23:52

Request For Quotation

1,3-Dimethyl-5-pyrazolone Properties

Melting point	117°C
Boiling point	210.05°C (rough estimate)
Density	1.1524 (rough estimate)
refractive index	1.4730 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly, Sonicated), Met
form	Solid
pka	2.93±0.50(Predicted)
color	Off-White to Light Beige
Water Solubility	almost transparency
InChI	InChI=1S/C5H8N2O/c1-4-3-5(8)7(2)6-4/h3H2,1-2H3
InChIKey	JXPVQFCUIAKFLT-UHFFFAOYSA-N
SMILES	N1=C(C)CC(=O)N1C
CAS DataBase Reference	2749-59-9(CAS DataBase Reference)
NIST Chemistry Reference	3H-Pyrazol-3-one, 2,4-dihydro-2,5-dimethyl-(2749-59-9)
EPA Substance Registry System	3H-Pyrazol-3-one, 2,4-dihydro-2,5-dimethyl- (2749-59-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37/39

Hazard Note

Irritant

TSCA

TSCA listed

HS Code

2933199090

REACH Registrations

Active

NFPA 704

	0
1		0

1,3-Dimethyl-5-pyrazolone price More Price(74)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D2031	1,3-Dimethyl-5-pyrazolone >98.0%(HPLC)(T)	2749-59-9	25g	$57	2026-04-30	Buy
TCI Chemical	D2031	1,3-Dimethyl-5-pyrazolone >98.0%(HPLC)(T)	2749-59-9	100g	$144	2026-04-30	Buy
TRC	TRC-D479005-10G	1,3-Dimethyl-5-pyrazolone	2749-59-9	10g	$108	2026-06-03	Buy
Biosynth	FD22306	1,3-Dimethyl-5-pyrazolone	2749-59-9	5g	$216	2026-06-04	Buy
Biosynth	FD22306	1,3-Dimethyl-5-pyrazolone	2749-59-9	10g	$345.5	2026-06-04	Buy

Product number	Packaging	Price	Buy
D2031	25g	$57	Buy
D2031	100g	$144	Buy
TRC-D479005-10G	10g	$108	Buy
FD22306	5g	$216	Buy
FD22306	10g	$345.5	Buy

1,3-Dimethyl-5-pyrazolone Chemical Properties, Uses, Production

Chemical Properties

Light Beige Solid

Uses

1,3-Dimethyl-5-pyrazolone (cas# 2749-59-9) is a compound useful in organic synthesis.

Synthesis

141-97-9

60-34-4

2749-59-9

Methylhydrazine (4.47 mL, 84.99 mmol) was added slowly and dropwise to a solution of ethyl 3-oxohexanoate (11.06 g, 84.99 mmol) in anhydrous ethanol (100 mL) at 0 °C. The reaction system was naturally warmed to room temperature with continuous stirring for 3.5 hours. Subsequently, the reaction mixture was heated to 60 °C and the reaction was continued for 10 hours and kept at reflux for 2.5 hours. Upon completion of the reaction, the mixture was concentrated to dryness using a rotary evaporator to afford intermediate 4 as a viscous pink solid (9.52 g, 100% yield). The structure of intermediate 4 was confirmed by 1H NMR (400 MHz, CDCl3) and mass spectrometry (ESI): 1H NMR (400 MHz, CDCl3) δ (ppm): 5.06 (s, 1H), 3.85 (bs, 1H), 3.32 (s, 3H), 1.94 (s, 3H); MS (ESI): m/z calculated value ( C15H9N2O) was 113.1 and the measured value was 113.2 ([M+H]+).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 13, p. 3307 - 3312
[2] Patent: WO2016/205460, 2016, A1. Location in patent: Paragraph 0140-0141
[3] Patent: WO2016/7905, 2016, A1. Location in patent: Page/Page column 37
[4] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 23, p. 5815 - 5818
[5] Patent: US4382948, 1983, A

1,3-Dimethyl-5-pyrazolone Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Acetyl ketene Methylhydrazine

Preparation Products

tert-Butyl 4-[[[(E)-[(1,3-Dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylene]amino]oxy]methyl]benzoate 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carbaldehyde Pyrazole-1,3-dimethyl-5-phenoxy-4-carboxaldehyde oxime

1,3-Dimethyl-5-pyrazolone Suppliers

Global Suppliers ( 267)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Tombiopharma Chemical Co. Ltd.	13391076197	tombiopharma@163.com	China	4986	55
Shijiazhuang Feizi Chemical Technology Co. LTD	0311-85957988 18633001459	sales@feizichem.com	China	82	58
Jinan Junhe Pharmaceutical Co., Ltd	+86-13053355392 +86-13053355392	957395144@qq.com	China	280	58
Shandong Mingde Biotechnology Co., Ltd.	18560864701	2037956468@qq.com	China	831	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57
Ark Pharm, Inc.	847-367-3680	sales@arkpharminc.com	United States	1669	56
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66

Supplier	Advantage
Shanghai Tombiopharma Chemical Co. Ltd.	55
Shijiazhuang Feizi Chemical Technology Co. LTD	58
Jinan Junhe Pharmaceutical Co., Ltd	58
Shandong Mingde Biotechnology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
TCI (Shanghai) Development Co., Ltd.	81
ShangHai DEMO Chemical Co.,Ltd	57
Ark Pharm, Inc.	56
Energy Chemical	61
Capot Chemical Co., Ltd	66

View Latest Price from 1,3-Dimethyl-5-pyrazolone manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-02-04	1,3-dimethyl-5-pyrazolone 2749-59-9	$1.00	1KG	99%	2000ton	Shaanxi Dideu Medichem Co. Ltd
	2020-01-08	1,3-Dimethyl-5-pyrazolone 2749-59-9	$2.00	1KG	98%	100g , 1kg, 5kg , 50kg	Career Henan Chemical Co

1,3-dimethyl-5-pyrazolone
2749-59-9
$1.00
99%
Shaanxi Dideu Medichem Co. Ltd

1,3-Dimethyl-5-pyrazolone
2749-59-9
$2.00
98%
Career Henan Chemical Co

1,3-Dimethyl-5-pyrazolone Spectrum

1,3-Dimethyl-5-pyrazolone(2749-59-9)MS 1,3-Dimethyl-5-pyrazolone(2749-59-9)¹HNMR 1,3-Dimethyl-5-pyrazolone(2749-59-9)¹³CNMR 1,3-Dimethyl-5-pyrazolone(2749-59-9)IR1 1,3-Dimethyl-5-pyrazolone(2749-59-9)IR2

2749-59-9 (1,3-Dimethyl-5-pyrazolone) Related Search:

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Ethane Dimethylglyoxime disodium salt 1,2-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one 3-Methyl-1-(4-sulfophenyl)-2-pyrazolin-5-one 1-(4'-Sulfophenyl)-3-carboxy-5-pyrazolone

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1of4

1,3-diMethyl-5-pyrozolone NSC 304 2,5-DiMethyl-1H-pyrazol-3(2H)-one 2,5-Dimethyl-2,4-dihydro-3H-pyrazol-3-one 2-Pyrazolin-5-one, 1,3-dimethyl- BUTTPARK 82\11-61 1,3-DIMETHYL-4,5-DIHYDRO-1H-PYRAZOL-5-ONE 1,3-DIMETHYLPYRAZOLONE 1,3-DIMETHYL-5-PYRAZOLONE 4,5-Dihydro-1,3-dimethyl-1H-pyrazol-5-one, 2,4-Dihydro-2,5-dimethyl-3-oxo-3H-pyrazole 1,3-Dimethyl-5-pyrazolinone 2,4-DIHYDRO-2,5-DIMETHYL-3H-PYRAZOL-3-ONE 1,3-dimethyl-5-pyrazolone(DMP) 3H-PYRAZOL-3-ONE, 2,4-DIHYDRO-2,5-DIMETHYL- 1,3-dimethyl-1H-pyrazol-5(4H)-one 1,3-DIMETHYL-5-PYRAZOLONE 95+% 2,5-Dimethyl-2,4-dihydro-3H-pyrazole-3-one 2,5-Dimethyl-2H-pyrazole-3(4H)-one 1,3-Dimethyl-5-pyrazolone,97% 2,5-dimethyl-4H-pyrazol-3-one 1,3-Dimethyl-5-pyraz 1,3-Dimethylpyrazol-5(4H)-one 2,4-Dihydro-2,5-dimethyl-3H-pyrazol-3-one 95% 1,3-Dimethyl-5-pyrazolone > 1,3-dimethyl-2-pyrazolin-5-one 2749-59-9 2749-59-5 C5H8N2O Heterocycles Miscellaneous Reagents Intermediates of Dyes and Pigments Pyrazole Pyrazoles & Triazoles