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Meglumine

Meglumine Structure
Meglumine structure
CAS No.
6284-40-8
Chemical Name:
Meglumine
Synonyms
N-METHYL-D-GLUCAMINE;N-METHYLGLUCAMINE;Meglumin;Methylglucamine;1-deoxy-1-(methylamino)-d-glucito;MeguMine;Meglumine CRS;Methylglucamin;D(-)-N-METHYLGLUCAMINE;1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL
CBNumber:
CB6411710
Molecular Formula:
C7H17NO5
Molecular Weight:
195.21
MDL Number:
MFCD00004707
MOL File:
6284-40-8.mol
MSDS File:
SDS
Last updated:2025-10-17 20:33:23
Product description Number Pack Size Price
Meglumine European Pharmacopoeia (EP) Reference Standard Y0001209 10 mg $164
D(-)-N-Methylglucamine for resolution of racemates for synthesis 8.18318 250g $67.6
N-Methyl-D-glucamine ReagentPlus , ≥99.0% (T) 66930 100g $69.9
Meglumine EMPROVE? ESSENTIAL, Ph. Eur., ChP, JP, USP 1.06187 1KG $275
Meglumine United States Pharmacopeia (USP) Reference Standard 1379140 500mg $410
More product size
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Meglumine Properties

Melting point 129-131.5 °C (lit.)
alpha -16.5 º (c=10, H2O, on dry sub)
Boiling point 331.88°C (rough estimate)
Density 1.2669 (rough estimate)
bulk density 300kg/m3
refractive index -16.5 ° (C=2, H2O)
RTECS LZ4295770
storage temp. 2-8°C
solubility H2O: 0.1 g/mL, clear, colorless
pka pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
form Crystalline Powder
color White to almost white
PH 11 (10g/l, H2O, 20℃)
biological source synthetic (organic)
optical activity [α]20/D 16.5±0.5°, c = 2% in H2O
Water Solubility 100 g/100 mL (25 ºC)
Sensitive Air Sensitive & Hygroscopic
Merck 14,6078
BRN 385906
InChIKey MBBZMMPHUWSWHV-VZFHVOOUSA-N
LogP -3.370 (est)
EWG's Food Scores 1
FDA UNII 6HG8UB2MUY
NIST Chemistry Reference N-methylglucamine(6284-40-8)
EPA Substance Registry System Meglumine (6284-40-8)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Risk Statements  36/37/38
Safety Statements  24/25
WGK Germany  3
F  3-10-23
Autoignition Temperature ~662 °F
TSCA  Yes
HS Code  29221980
Toxicity LD50 orally in Rabbit: > 5000 mg/kg
NFPA 704
0
0 1

Meglumine price More Price(52)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001209 Meglumine European Pharmacopoeia (EP) Reference Standard 6284-40-8 10 mg $164 2025-07-31 Buy
Sigma-Aldrich 8.18318 D(-)-N-Methylglucamine for resolution of racemates for synthesis 6284-40-8 250g $67.6 2025-07-31 Buy
Sigma-Aldrich 66930 N-Methyl-D-glucamine ReagentPlus , ≥99.0% (T) 6284-40-8 100g $69.9 2025-07-31 Buy
Sigma-Aldrich 1.06187 Meglumine EMPROVE? ESSENTIAL, Ph. Eur., ChP, JP, USP 6284-40-8 1KG $275 2025-07-31 Buy
Sigma-Aldrich 1379140 Meglumine United States Pharmacopeia (USP) Reference Standard 6284-40-8 500mg $410 2025-07-31 Buy
Product number Packaging Price Buy
Y0001209 10 mg $164 Buy
8.18318 250g $67.6 Buy
66930 100g $69.9 Buy
1.06187 1KG $275 Buy
1379140 500mg $410 Buy

Meglumine Chemical Properties,Uses,Production

Chemical Properties

white to almost white crystalline powder

Chemical Properties

Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.

Uses

antiinflammatory

Uses

excipient in cosmetics and X-ray contrast media

Uses

N-Methyl-D-glucamine is used in conjunction with iodinated organic compounds in contrast media viz. diatrizoate meglumine and iodipamide meglumine. It is useful in ion-exchange resins to chelate boron ions selectively. It is also used as an excipient in pharmaceuticals, in cosmetics and X-ray contrast media. It is also employed in the synthesis of surface active agents, pharmaceuticals and dyes.

Production Methods

Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation.

Definition

ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.

brand name

Renovue (Bracco).

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Meglumine is a glucose-derived secondary amine which is widely used as an excipient in pharmaceutical formulations.

Pharmaceutical Applications

Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.

Safety

Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient.
LD50 (mouse, IP): 1.68 g/kg

storage

Meglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods.
The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended.

Purification Methods

Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.]

Incompatibilities

Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide.

Regulatory Status

Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK.

References

[1] Patent: US2014/255330, 2014, A1. Location in patent: Paragraph 0207
[2] Patent: US1994467, 1932,
[3] Helvetica Chimica Acta, 1937, vol. 20, p. 83,85
[4] Chemische Berichte, 1966, vol. 99, p. 812 - 822
[5] RSC Advances, 2014, vol. 4, # 10, p. 5152 - 5155

Meglumine synthesis

50-99-7
74-89-5
6284-40-8
Synthesis of Meglumine from D(+)-Glucose and Methylamine

Meglumine Preparation Products And Raw materials

Raw materials

Ethanol solution 1-Glucose-methylamine schiffbase ACETALDEHYDE AMMONIA D(+)-Glucose Flunixin Meglumine Impurity 9
Methylamine Water Hydrogen

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Preparation Products

MGD SODIUM SALT MONOHYDRATE Delafloxacin meglumine

Meglumine Suppliers

Global( 780)Suppliers
Supplier Tel Email Country ProdList Advantage
SIMAGCHEM CORP
+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Hebei Yanxi Chemical Co., Ltd.
+8618531123677 faithe@yan-xi.com China 5853 58
Wuhan Silworld Chemical Co.,Ltd
+86-027-85613400 +86-15827173649 info@silworldchemical.com China 178 58
Anhuyan (Hainan) Biotechnology Co., LTD
+86-18163349544; +8618163349544 mollylucking@foxmail.com China 3000 58
Taizhou Creating Bio-pharm co., ltd.
0576-88827176; +8613586099526 post@creatingbiopharm.com China 219 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8772 58
Wuhan Fortuna Chemical Co., Ltd 		+86-027-59207850 +86-13986145403; info@fortunachem.com China 5997 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5251 58
Changzhou Rokechem Technology Co., Ltd. 		18758118018 sales001@rokechem.com China 255 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 973 58
Supplier Advantage
SIMAGCHEM CORP
58
Hebei Yanxi Chemical Co., Ltd.
58
Wuhan Silworld Chemical Co.,Ltd
58
Anhuyan (Hainan) Biotechnology Co., LTD
58
Taizhou Creating Bio-pharm co., ltd.
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Wuhan Fortuna Chemical Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Changzhou Rokechem Technology Co., Ltd. 		58
Anhui Ruihan Technology Co., Ltd 		58

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View Lastest Price from Meglumine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Meglumine pictures 2025-10-18 Meglumine
6284-40-8
 0.99 RongNa Biotechnology Co.,Ltd
N-methylglucamine pictures 2025-10-17 N-methylglucamine
6284-40-8
 US $1.00 / g 300g 99.8% 20 TONS .GZ HONESTCHEM CO.,LTD
Meglumine pictures 2025-10-17 Meglumine
6284-40-8
 US $0.00-0.00 / kg 1kg 99%min 500kgs WUHAN FORTUNA CHEMICAL CO., LTD
  • Meglumine pictures
  • Meglumine
    6284-40-8
  • 0.99
  • RongNa Biotechnology Co.,Ltd
  • Meglumine pictures
  • Meglumine
    6284-40-8
  • US $0.00-0.00 / kg
  • 99%min
  • WUHAN FORTUNA CHEMICAL CO., LTD

Meglumine Spectrum

Meglumine(6284-40-8)MSMeglumine(6284-40-8)IR1Meglumine(6284-40-8)IR2Meglumine(6284-40-8)Raman

6284-40-8(Meglumine)Related Search:

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Liometacen (meglumine salt),Liometacen [as meglumine salt] D-GLUCAMINE Glucosamine gadolinium DOTA meglumine iodipamide meglumine salt,meglumine iodipamide
MEGLUMINE - REFERENCE SPECTRUM Iothalamate meglumine meglumine ioxithalamate,ioxitalamic acid meglumine salt meglumine iodamide,iodamide meglumine salt meglumine indomethacinate
MEGLUMINE DIATRIAZOATE iodoxamic acid meglumine salt FLUNIXIN MEGLUMINE IMP. C (EP): ETHYL 2-CHLOROPYRIDINE-3-CARBOXYLATE

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1-deoxy-1-(methylamino)-d-glucito 1-Deoxy-1-(methylamino)hexitol Glucitol, 1-deoxy-1-(methylamino)-, D- Meglumin Methylglucamin Methylglucamine D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)- D(-)-N-METHYLGLUCAMINE 1-DEOXY-1-(METHYLAMINO)GLUCITOL 1-DEOXY-1-METHYLAMINOSORBITOL 1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL N-METHYL-D(-)-GLUCAMINE N-METHYL-D-GLUCAMINE N-METHYLGLUCAMINE Methylglucamine,99% N-Methyl-D-glucamine N-Methyl-D-Glucamine(Or) Meglumine N-Methyl-D-glucamine Vetec(TM) reagent grade, 99% Fosaprepitant Impurity H C7H18NO5 D(-)-N-Methylglucamine for resolution of racemates for synthesis methyl-[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]ammonium ucamine N-Methyl-D-Glu METHYL GLUCAMINE MEGLUMINE MEGLUMINE, USP N-Methylglucamine (Meglumine) N-Methyl-D-Glucamine>99% MeglumineAntimoniateBase N-METHYL-D-GLUCANINE MEGLUMINE(N-METHYLGLUCAMINE) N-METHYLCYCLOHEXALAMINE N-METHYL-D-GLUCAMINE USP 1-(Methylamino)-1-deoxy-D-glucitol 1-Methylamino-1-deoxy-D-glucitol D-1-Deoxy-1-(methylamino)glucitol MegluMine (AS) Meglumine, 1-Deoxy-1-(methylamino)-D-glucitol, (2R,3R,4R,5S)-6-Methylaminohexane-1,2,3,4,5-pentaol, 1-Deoxy-1-methylaminosorbitol N-MethylglucaMin (MegluMine) Meglumine (500 mg) (AS) N-Methyl-D-glucaMine, 99% 100GR N-Methyl-D-glucaMine, 99% 2.5KG N-Methyl-D-glucaMine, 99% 500GR MegluMine,USP,BP,EP MeguMine N-Methyl-D-glucaMine 99.0-100.5% (titration) N-Methyl-D-glucaMine ReagentPlus(R), >=99.0% (T) N-Methyl-D-glucaMine , 99.0%(T) N-MethylglucaMine USP D(-)-N-METHYLGLUCAMINE FOR RESOLUTION OF (2R,3R,4R,5S)-6-(MethylaMino)hexane-1,2,3,4,5-pentaol The most popular N-methylglucamine Meglumine CRS N-Methyl-D-glucamine, 99%, reagent grade N-Methyl-D-glucamine> -D-gL Meglumine, USP, EP, BP Meglumine CPH4 5KG