15-28-Somatostatin-28

15-28-Somatostatin-28 Properties

Melting point	>211°C (dec.)
Boiling point	1970.9±65.0 °C(Predicted)
Density	1.43±0.1 g/cm3(Predicted)
storage temp.	−20°C
solubility	H₂O: 1 mg/mL
form	powder
pka	2.94±0.70(Predicted)
color	White to Off-White
Water Solubility	Soluble in water(25,00°C 1,00 g/L), Methanol.
Merck	13,8788
BRN	6436064
Sequence	Ala-Gly-c[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys]-OH,(Disulfide bridge: Cys-Cys)
InChIKey	NHXLMOGPVYXJNR-ATOGVRKGSA-N
EWG's Food Scores	1
FDA UNII	6E20216Q0L
UNSPSC Code	12352200
NACRES	NA.32

SAFETY

Risk and Safety Statements

PPE	Eyeshields, Gloves, type N95 (US)
WGK Germany	3
RTECS	WF8751700
F	3-10-21
Storage Class	11 - Combustible Solids

15-28-Somatostatin-28 price More Price(63)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S9129	Somatostatin ≥97%(HPLC),powder	38916-34-6	0.5mg	$105	2026-04-30	Buy
Sigma-Aldrich	S1763	Somatostatin powder,BioReagent,suitableforcellculture	38916-34-6	0.1mg	$68.1	2026-04-30	Buy
Sigma-Aldrich	S0945000	Somatostatin European Pharmacopoeia (EP) Reference Standard	38916-34-6	2.09 mg	$283	2026-04-30	Buy
Sigma-Aldrich	S0885	Somatostatin powder,γ-irradiated,BioXtra,suitableforcellculture	38916-34-6	20μg	$40.68	2024-03-01	Buy
Usbiological	021008	Somatostatin Acetate	38916-34-6	10mg	$418	2026-06-03	Buy

Product number	Packaging	Price	Buy
S9129	0.5mg	$105	Buy
S1763	0.1mg	$68.1	Buy
S0945000	2.09 mg	$283	Buy
S0885	20μg	$40.68	Buy
021008	10mg	$418	Buy

15-28-Somatostatin-28 Chemical Properties, Uses, Production

Chemical Properties

White Powder

Uses

Growth hormone-release inhibiting factor; treatment of severe, acute hemorrhage of gastroduodenal ulcers; experimental antidiabetic.

Definition

ChEBI: A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14.

Biological Functions

Somatostatin is a cyclic 14-peptide that was first isolated by Guillemin in 1973 and is probably the most thoroughly investigated and most important of the inhibitory factors produced by the hypothalamus. The principal activity of somatostatin, which is of hypothalamic origin, is inhibition of the release of growth hormone (GH) from the anterior pituitary. Too much GH, as in pituitary tumors, causes acromegaly, a form of giantism. On the other hand, too little GH leads to dwarfism. Somatostatin also has been found in the pancreas and the GI tract, where it inhibits the secretion of both insulin and glucagon from the pancreas as well as the secretion of a variety of intestinal peptides (e.g., gastrin, secretin, pepsin, and renin). The short half-life of somatostatin, which is less than 3 minutes, has precluded its use as a therapeutic agent. Many derivatives of somatostatin have been prepared to increase its duration of action and/or to enhance its selectivity of action. The culmination of these structure–activity studies was the development of octreotide acetate.

General Description

Somatostatin (SST) is a peptide.

Biochem/physiol Actions

Somatostatin regulates the secretion of hormones and bioactive peptides. It acts as an inhibitor in the digestive tract by inhibiting gastrin release. In the pancreatic islets, it inhibits glucagon and insulin release. Somatostatin and its synthetic analogs have been used in the treatment of neuroendocrine tumors.

Purification Methods

Somatostatin is a tetradecapeptide which is purified by gel filtration on Sephadex G-25, eluting with 2N AcOH, and then by liquid partition chromatography on Sephadex G-25 using n-BuOH/AcOH/H2O (4:1:5) and has RF = 0.4. It is a brain growth hormone releasing-inhibiting factor which has also been synthesised. [Burgus et al. Proc Natl Acad Sci USA 70 684 1973, Sorantakis & McKinley Biochem Biophys Res Commun 54 234 1973, Hartridt et al. Pharmazie 37 403 1982.]

15-28-Somatostatin-28 synthesis

Synthesis of 15-28-Somatostatin-28 from dihydrosomatostatin

15-28-Somatostatin-28 Preparation Products And Raw materials

Raw materials

L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-L-alanylglycyl-L-cysteinyl-N6-[(1,1-dimethylethoxy)carbonyl]-L-lysyl-N-(triphenylmethyl)-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-1-[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-N6-[(1,1-dimethylethoxy)carbonyl]-L-lysyl-O-(1,1-dimethylethyl)-L-threonyl-L-phenylalanyl-O-(1,1-dimethylethyl)-L-threonyl-O-(1,1-dimethylethyl)-L-seryl-, [3,4,5-tris(octadecyloxy)phenyl]methyl ester, cyclic (3→14)-disulfide dihydrosomatostatin

Preparation Products

15-28-Somatostatin-28 Suppliers

Global Suppliers ( 348)

Supplier	Tel	Email	Country	ProdList	Advantage
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	1010	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
ChemFuture PharmaTech (Jiangsu) Ltd	5108538618	suger.wang@chemfuture.com	China	832	65
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2110	70
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6742	52
China Langchem Inc.	0086-21-58956006		China	7798	57

Supplier	Advantage
Cellmano Biotech Limited	55
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
ChemFuture PharmaTech (Jiangsu) Ltd	65
LGM Pharma	70
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
XiaoGan ShenYuan ChemPharm co,ltd	52
China Langchem Inc.	57

View Latest Price from 15-28-Somatostatin-28 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-16	Somatostatin Acetate 38916-34-6		1g	98%min	1000g	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-15	Somatostatin Acetate 38916-34-6	$5.00	1Box	99.99%	20000 boxes	Hebei Jiafan Trading Company Limited
2026-08-25	15-28-Somatostatin-28 38916-34-6	$65.00-650.00	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd

Somatostatin Acetate
38916-34-6
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Somatostatin Acetate
38916-34-6
$5.00
99.99%
Hebei Jiafan Trading Company Limited

15-28-Somatostatin-28
38916-34-6
$65.00-650.00
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

15-28-Somatostatin-28 Spectrum

15-28-Somatostatin-28(38916-34-6)MS

38916-34-6 (15-28-Somatostatin-28) Related Search:

SOMATOSTATIN 28, CYCLIC Somatostatin Oxytocin Bivalirudin trifluoroacetate salt Somatostatin-28 (1-14)

H-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH Somatostatin-28 (1-12) H-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-OH H-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-OH H-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH

SOMATOSTATIN-25 SOMATOSTATIN 28 Hexarelin Growth hormone releasing peptide 15-28-Somatostatin-28

GROWTH HORMONE, HUMAN (TYR11)-SOMATOSTATIN-14 BIOTINYL-SOMATOSTATIN-14

1of4

Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH SoMatotropin Release-Inhibiting Factor, SRIF, SRIF-14 Cyclic somatostatin SoMatostatin Acetat GROWTH HORMONE RELEASE INHIBITING FACTOR (HUMAN, OVINE, PORCINE, RAT, MOUSE) GROWTH HORMONE RELEASE INHIBITING FACTOR (HUMAN, OVINE, PORCINE, RAT, MOUSE) 2ACOH 6H2O H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH (COUPLED TO BSA) H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH (COUPLED TO KLH) H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH, CYS3,14, CYCLIC H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH (DISULFIDE BRIDGE: 3-14) GIF (HUMAN, OVINE, PORCINE, RAT, MOUSE) GIF (HUMAN, OVINE, PORCINE, RAT, MOUSE) 2ACOH 6H2O GH-RIF ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-PHE-THR-SER-CYS-OH ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS 2ACOH 6H2O AGCKNFFWKTFTSC AGCKNFFWKTFTSC (DISULFIDE BRIDGE: 3-14) SOMATOSTATIN-14 SOMATOSTATIN-14 (COUPLED TO BSA) SOMATOSTATIN-14 (COUPLED TO KLH) SOMATOSTATIN-14 (REDUCED) SOMATOSTATIN, CYCLIC SOMATOSTATIN [D-TRP8] SOMATOSTATIN [GIF] SOMATOSTATIN (HUMAN, OVINE, PORCINE, RAT, MOUSE) SOMATOSTATIN (HUMAN, OVINE, PORCINE, RAT, MOUSE) 2ACOH 6H2O SOMATOSTATIN, SHEEP SOMATOSTATIN [TYR1] SOMATOTROPIN RELEASE INHIBITING FACTOR SOMATOTROPIN RELEASE INHIBITING FACTOR (HUMAN, OVINE, PORCINE, RAT, MOUSE) SOMATOTROPIN RELEASE INHIBITING FACTOR (HUMAN, OVINE, PORCINE, RAT, MOUSE) 2ACOH 6H2O SRIF Growth hormone-release inhibiting factor: L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3-14) disulfide Somatostatina Somatostatina [inn-spanish] Somatostatine Growth hormone release inhibiting factor Somatotropin release inhibiting factor SRIF-14;SOMATOSTATIN-14 Cyclic somatostatin (SRIF-14 Somatostatin-14, ≥97% (HPLC) SRIF (HUMAN, OVINE, PORCINE, RAT, MOUSE) SRIF (HUMAN, OVINE, PORCINE, RAT, MOUSE) 2ACOH 6H2O H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (Disulfide bond) somatostatin gamma-irradiated*cell culture tested SOMATOSTATIN, CELL CULTURE TESTED Growth hormone-releasing inhibiting factor Argirelin Acetate Somastostatin Acetate Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH, (Disulfide Bridge3:14) 15-28-Somatostatin-28 Synthetic cyclic growth hormone release-inhibiting factor Synthetic somatostatin-14 Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys (Disulfide bridge Cys3-Cys14) H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH acetate salt (Disulfide bond) SOMATOSTATIN PH. EUR. Aminopan