6-(Chloromethyl)uracil
- CAS No.
- 18592-13-7
- Chemical Name:
- 6-(Chloromethyl)uracil
- Synonyms
- Tipiracil-002;6-(CHLOROMETHYL;TIMTEC-BB SBB003961;Tipiracil Impurity 14;6-(CHLOROMETHYL)URACIL;4-(chloromethyl)uracil;5-CHLORO-6-METHYLURACIL;6-methyl-5-chlorouracil;6-Chloromethyluracil >6-(Chloromethyl)uracil,98%
- CBNumber:
- CB6417853
- Molecular Formula:
- C5H5ClN2O2
- Molecular Weight:
- 160.56
- MDL Number:
- MFCD00010095
- MOL File:
- 18592-13-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 257 °C (dec.)(lit.) |
|---|---|
| Density | 1.393±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | almost transparency in N,N-DMF |
| form | powder to crystal |
| pka | 7.91±0.10(Predicted) |
| color | White to Light yellow |
| InChI | InChI=1S/C5H5ClN2O2/c6-2-3-1-4(9)8-5(10)7-3/h1H,2H2,(H2,7,8,9,10) |
| InChIKey | VCFXBAPEXBTNEA-UHFFFAOYSA-N |
| SMILES | C1(=O)NC(CCl)=CC(=O)N1 |
| CAS DataBase Reference | 18592-13-7(CAS DataBase Reference) |
| EPA Substance Registry System | 2,4(1H,3H)-Pyrimidinedione, 6-(chloromethyl)- (18592-13-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
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6-(Chloromethyl)uracil price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 183946 | 6-(Chloromethyl)uracil 98% | 18592-13-7 | 5g | $35.5 | 2026-04-30 | Buy |
| TCI Chemical | C1057 | 6-Chloromethyluracil >98.0%(HPLC)(T) | 18592-13-7 | 5g | $48 | 2026-04-30 | Buy |
| TCI Chemical | C1057 | 6-Chloromethyluracil >98.0%(HPLC)(T) | 18592-13-7 | 25g | $189 | 2026-04-30 | Buy |
| Biosynth | FC76498 | 6-(Chloromethyl)uracil | 18592-13-7 | 250g | $900 | 2026-06-04 | Buy |
| Biosynth | FC76498 | 6-(Chloromethyl)uracil | 18592-13-7 | 100g | $900 | 2026-06-04 | Buy |
6-(Chloromethyl)uracil Chemical Properties,Uses,Production
Uses
6-(Chloromethyl)uracil is an alkali-resistant protein adsorbent, suitable for medical procedures. it is also used in the synthesis of chlorophenyl hydroxypiperidine analogs having anti-amylatic activity.
Synthesis
22126-44-9
18592-13-7
In a 250 mL three-necked flask, 6-(hydroxymethyl)uracil (11.5 g, 0.081 mol) was added, followed by 115 mL of dichloromethane, thionyl chloride (17.6 mL, 0.24 mol) and a catalytic amount of N,N-dimethylformamide in sequence. The reaction mixture was heated to reflux temperature and stirred continuously for 2 hours. After completion of the reaction, it was cooled to room temperature, the solid product was collected by filtration, washed with dichloromethane and dried to give 6-(chloromethyl)uracil (11.8 g, 90.8% yield).
References
[1] European Journal of Medicinal Chemistry, 2013, vol. 70, p. 400 - 410
[2] Nucleosides, Nucleotides and Nucleic Acids, 2005, vol. 24, # 5-7, p. 367 - 373
[3] Patent: CN106831607, 2017, A. Location in patent: Paragraph 0049
[4] Patent: CN106892902, 2017, A. Location in patent: Paragraph 0099; 0100; 0101; 0102
6-(Chloromethyl)uracil Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Sino Rare Chemical Co., Ltd. | 0512-62857507 | sales@sinorarechem.com | China | 999 | 58 |
| Shanghai Zhuorui Chemical Co.,Ltd. | 021-69180038 | zhuoruichem@163.com | China | 105 | 58 |
| Jinan XuanDe Chemical Co., Ltd. | 0531-88803958 19862127196 | zhangxu@shiningpharm.com | China | 201 | 58 |
| Chengdu Keruijia Pharm Technology Co., Ltd | 18290480864 | 3440389861@qq.com | China | 462 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
View Lastest Price from 6-(Chloromethyl)uracil manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-08 | 6-Chloromethyluracil
18592-13-7
|
1kg | 99% | 1 | Jinan Ruitong Biotech Co., Ltd. | ||
 |
2025-04-04 | 6-(Chloromethyl)uracil
18592-13-7
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
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 |
2020-05-15 | 6-(ChloroMethyl)uracil
18592-13-7
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- 6-Chloromethyluracil
18592-13-7
- 99%
- Jinan Ruitong Biotech Co., Ltd.
-
- 6-(Chloromethyl)uracil
18592-13-7
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 6-(ChloroMethyl)uracil
18592-13-7
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
