4-Amino-piperidine-1-carboxylic acid benzyl ester
- CAS No.
- 120278-07-1
- Chemical Name:
- 4-Amino-piperidine-1-carboxylic acid benzyl ester
- Synonyms
- Benzyl 4-aminopiperidine-1-carboxylate;N-CBZ-4-aMinepiperidin;4-Amino-1-Z-piperidine;N-CBZ-4-aminepiperidine;1-CBZ-4-AMINOPIPERIDINE;4-AMINO-1-N-CBZ-PIPERIDINE;1-N-CBZ-4-AMINO-PIPERIDINE;4-Amino-1-carbobenzoxypiperidine;4-Amino-1-Cbz-piperidine - [A12336];4-Amino-1-benzyloxycarbonylpiperidine
- CBNumber:
- CB6427902
- Molecular Formula:
- C13H18N2O2
- Molecular Weight:
- 234.29
- MDL Number:
- MFCD05863884
- MOL File:
- 120278-07-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 68 °C(dec.) |
|---|---|
| Boiling point | 367.2±42.0 °C(Predicted) |
| Density | 1.151±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 10.07±0.20(Predicted) |
| form | powder to lump |
| color | White to Light yellow |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C13H18N2O2/c14-12-6-8-15(9-7-12)13(16)17-10-11-4-2-1-3-5-11/h1-5,12H,6-10,14H2 |
| InChIKey | YYIQGSYCCNQAGV-UHFFFAOYSA-N |
| SMILES | N1(C(OCC2=CC=CC=C2)=O)CCC(N)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-37-60 | |||||||||
| RIDADR | UN3259 | |||||||||
| HazardClass | 8 | |||||||||
| HS Code | 29333990 | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
4-Amino-piperidine-1-carboxylic acid benzyl ester price More Price(76)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2756 | 4-Amino-1-carbobenzoxypiperidine >98.0%(GC) | 120278-07-1 | 1g | $34 | 2026-04-30 | Buy |
| TCI Chemical | A2756 | 4-Amino-1-carbobenzoxypiperidine >98.0%(GC) | 120278-07-1 | 5g | $118 | 2026-04-30 | Buy |
| Usbiological | 430133 | 4-Amino-1-N-Cbz-piperidine | 120278-07-1 | 250mg | $319 | 2026-06-03 | Buy |
| Usbiological | 430133 | 4-Amino-1-N-Cbz-piperidine | 120278-07-1 | 500mg | $418 | 2026-06-03 | Buy |
| AstaTech | 56031 | 4-AMINO-1-N-CBZ-PIPERIDINE 97% | 120278-07-1 | 25G | $59 | 2026-04-30 | Buy |
4-Amino-piperidine-1-carboxylic acid benzyl ester Chemical Properties, Uses, Production
Uses
It is an important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.
Synthesis
159874-20-1
120278-07-1
General procedure for the synthesis of 1-Cbz-4-aminopiperidine (benzyl 4-aminopiperidine-1-carboxylate) from 1-Cbz-4-BOC-aminopiperidine: 4-(N-BOC amino)-Cbz piperidine (24.4 kg, 73.42 mol), THF (65 kg), and 5M HCl (23.0 kg, 110.13 mol) were mixed and heated to 30-35 °C for 2 h. The reaction was then continued at 55 °C overnight. After completion of the reaction, the mixture was cooled to 100 °C and dichloromethane (97 kg) and 10 M NaOH (7.97 kg, 145.12 mol) were added, controlling the temperature below 25 °C. After partitioning, the organic phase was washed with 25 wt% NaCl solution (27.5 kg). The washed organic phase was concentrated by distillation at atmospheric pressure to a volume of about 70 L. Subsequently, dichloromethane (162 kg) was added and concentrated by distillation again to a volume of about 120 L to give a dichloromethane solution of the title product 1-Cbz-4-aminopiperidine (17.2 kg, 100% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 7.33 (5H, m), 5.14 (2H, s), 4.14 (2H, br s), 2.87 (3H, m), 1.83 (2H, m), 1.66 (3H, m), 1.28 (2H, m).
References
[1] Patent: WO2009/91856, 2009, A2. Location in patent: Page/Page column 63-64
4-Amino-piperidine-1-carboxylic acid benzyl ester Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hobor Chemical Co., Ltd | 13918007836 | sales@hoborchem.com | China | 423 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
View Latest Price from 4-Amino-piperidine-1-carboxylic acid benzyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-05 | 4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
120278-07-1
|
$1.80-3.60 | 1KG | 99% | 88KG | Career Henan Chemical Co |
-
- 4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
120278-07-1
- $1.80-3.60
- 99%
- Career Henan Chemical Co
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