4-Hydroxybenzenesulfonic acid
- CAS No.
- 98-67-9
- Chemical Name:
- 4-Hydroxybenzenesulfonic acid
- Synonyms
- 4-Phenolsulfonic acid;P-HYDROXYBENZENESULFONIC ACID;P-PHENOLSULFONIC ACID;PHENOL-4-SULFONIC ACID;p-PhenoL;ARADUR 5003-1 BD;4-Hydroxyphenylsulfonic acid;4-hydroxybenzenesulphonic acid;C12849;p-Sulfophenol
- CBNumber:
- CB6442408
- Molecular Formula:
- C6H6O4S
- Molecular Weight:
- 174.17
- MDL Number:
- MFCD00007506
- MOL File:
- 98-67-9.mol
- MSDS File:
- SDS
| Melting point | 52 °C |
|---|---|
| Boiling point | 275.14°C (rough estimate) |
| Density | 1.337 g/mL at 25 °C |
| vapor pressure | 69.8Pa at 20℃ |
| refractive index |
n |
| solubility | Water (Slightly) |
| form | Liquid |
| pka | 9.11(at 25℃) |
| color | White to Light yellow to Light red |
| Specific Gravity | 1.337 |
| Viscosity | 166.2mm2/s |
| Water Solubility | Soluble in water. |
| Merck | 14,7246 |
| BRN | 1869034 |
| Henry's Law Constant | 3.8×107 mol/(m3Pa) at 25℃, HSDB (2015) |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChI | 1S/C6H6O4S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4,7H,(H,8,9,10) |
| InChIKey | FEPBITJSIHRMRT-UHFFFAOYSA-N |
| SMILES | Oc1ccc(cc1)S(O)(=O)=O |
| LogP | 0.41 at 25℃ |
| CAS DataBase Reference | 98-67-9(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | L74LRO149A |
| NIST Chemistry Reference | Benzenesulfonic acid, 4-hydroxy-(98-67-9) |
| EPA Substance Registry System | p-Phenolsulfonic acid (98-67-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H290-H314 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-68 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 1803 (PHENOLSULPHONIC ACID, LIQUID) | |||||||||
| WGK Germany | - | |||||||||
| RTECS | DB6970000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29089990 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Met. Corr. 1 Skin Corr. 1C |
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| Hazardous Substances Data | 98-67-9(Hazardous Substances Data) | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
4-Hydroxybenzenesulfonic acid price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 171506 | 4-Hydroxybenzenesulfonic acid solution 65 wt. % in H2O | 98-67-9 | 250ml | $81.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | 171506 | 4-Hydroxybenzenesulfonic acid solution 65 wt. % in H2O | 98-67-9 | 1l | $218 | 2026-04-30 | Buy |
| TCI Chemical | P0104 | 4-Hydroxybenzenesulfonic Acid Hydrate >85.0%(T) | 98-67-9 | 25g | $19 | 2026-04-30 | Buy |
| TCI Chemical | P0104 | 4-Hydroxybenzenesulfonic Acid Hydrate >85.0%(T) | 98-67-9 | 500g | $56 | 2026-04-30 | Buy |
| TRC | TRC-H807805-50G | 4-Hydroxybenzenesulfonic Acid (85%) | 98-67-9 | 50g | $262 | 2026-06-03 | Buy |
4-Hydroxybenzenesulfonic acid Chemical Properties, Uses, Production
Description
4-hydroxybenzenesulfonic acid is an arenesulfonic acid that is phenol substituted by a sulfo group at C-4. It is functionally related to a phenol. Results obtained in a comparative study using the disulfide-bridge containing peptide deaminoarginine-vasopressin and several commonly used matrices indicate that the reduction-inhibiting efficiency of 4-hydroxy benzene sulfonic acid is comparable to that of 3-nitrobenzyl alcohol while reduction is found to be important in matrices such as thioglycerol and glycerol. Experiments conducted on peptides such as met-enkephalin and bradykinin, nucleosides and other polar compounds reveal that 4-hydroxybenzenesulfonic acid is a good solvent and has physical properties similar to glycerol. This new matrix material is a radical scavenger, is surface active, allows persistent secondary-ion beams, and produces a low background signal[1].
Chemical Properties
yellowish oily liquid
Uses
4-Hydroxybenzenesulfonic Acid is used as a redox-mediator in the laccase-catalyzed degradation of indigo, a textile dye. Also used in oilfield chemicals, metal working, and as a polymerization catalyst.
Definition
ChEBI: An arenesulfonic acid that is phenol substituted by a sulfo group at C-4.
Production Methods
The synthesis of 4-Hydroxybenzenesulfonic acid is as follows：Phenol (25 kg) and 96% sulfuricacid(28 kg) are heated to 50 ℃; then1.25 kg additional sulfuric acid is added and the reaction mixture is heated at 110 ℃ for 5 – 6 h. Reaction water, together with about 5% of the phenol, is distilled off during this period. Yield 95%.
Application
Crude 4-hydroxybenzenesulfonic acid obtained by hot sulfonation, i.e., mixed with 2- hydroxybenzenesulfonic acid, is used as such in the manufacture of synthetic tanning agents. Condensation products of phenolsulfonic acid mixtures with formaldehyde improve the dyeing properties of polyamide fibers. 4-Hydroxybenzenesulfonic acid and 2-halogenomalonic esters form the corresponding ethers, which are used in the manufacture of polyesters with improved affinity for basic dyes. If a mixture of hydroxybenzenesulfonic acids and bis(hydroxyphenyl) sulfone is condensed with formaldehyde, and hydrogensulfite is subsequently added, substances with good dispersing effects on dyes are obtained. They also are used as thinning agents for cement. Most of the 4-hydroxybenzenesulfonic acid is used as an additive for electroplating baths. By comparison, the acid is relatively unimportant as a dye intermediate. With ethylene oxide it forms poly(ethoxy)oxybenzenesulfonic acid, which can be used as a plasticizer and emulsifier.
Flammability and Explosibility
Non flammable
References
[1] J. Visentini, Michel J. Bertrand, P. M. Nguyen. “The use of 4-hydroxybenzenesulfonic acid as a reduction-inhibiting matrix in liquid secondary-ion mass spectrometry.” Rapid Communications in Mass Spectrometry 5 12 (1991): 586–590.
4-Hydroxybenzenesulfonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1of5
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Datang Chemical Co., Ltd | 025-85431992 13951889900 | vip@chemdatang.com | China | 100 | 66 |
| Changzhou Junchi Chemical Co.,ltd. | 0519-85518211 15195021697 | 85518211@chemjunchi.com | China | 64 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6742 | 52 |
View Latest Price from 4-Hydroxybenzenesulfonic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-09-16 | 4-Hydroxybenzenesulfonic acid
98-67-9
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
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2026-09-02 | 4-Hydroxybenzenesulfonic acid
98-67-9
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
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2026-05-28 | 4-Hydroxybenzenesulfonic acid
98-67-9
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 4-Hydroxybenzenesulfonic acid
98-67-9
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 4-Hydroxybenzenesulfonic acid
98-67-9
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Hydroxybenzenesulfonic acid
98-67-9
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
