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N-(2-Hydroxypropyl)methacrylamide

N-(2-Hydroxypropyl)methacrylamide Structure
N-(2-Hydroxypropyl)methacrylamide structure
CAS No.
21442-01-3
Chemical Name:
N-(2-Hydroxypropyl)methacrylamide
Synonyms
DK668;DK667;DKFELEX0166;2-Hydroxypropyl methacrylamide;N-(2-HYDROXYPROPYL)METHACRYLAMID;N-(2-Hydroxypropyl)methacrylamide;N-(2-Hydroxypropyl)methacrylamide,98%;N - (2-hydroxypropyl) methylacrylamide;2-Hydroxypropyl methacrylamide 99% (GC);N-(2-Hydroxypropyl)-2-methyl-prop-2-enamide
CBNumber:
CB6446345
Molecular Formula:
C7H13NO2
Molecular Weight:
143.18
MDL Number:
MFCD00080531
MOL File:
21442-01-3.mol
MSDS File:
SDS
Last updated:2026-09-12 18:54:16
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N-(2-Hydroxypropyl)methacrylamide Properties

Melting point 67.92°C
Boiling point 321.2±34.0 °C(Predicted)
Density 1.002 g/mL ((predicted))
storage temp. 2-8°C
solubility Soluble in DMSO
pka 14.43±0.20(Predicted)
form powder
color White to off-white
InChI 1S/C7H13NO2/c1-5(2)7(10)8-4-6(3)9/h6,9H,1,4H2,2-3H3,(H,8,10)
InChIKey OKPYIWASQZGASP-UHFFFAOYSA-N
SMILES CC(O)CNC(=O)C(C)=C
FDA UNII R3F262Z4E0
UNSPSC Code 12352200
NACRES NA.23

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P302+P352-P305+P351+P338-P362+P364
Risk Statements  36/37/38
Safety Statements  26-36/37/39
WGK Germany  3
HS Code  2924297099
Storage Class 11 - Combustible Solids

N-(2-Hydroxypropyl)methacrylamide price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich ANV00013 N-(2-Hydroxypropyl)-2-methyl-prop-2-enamide AldrichCPR 21442-01-3 1G $197 2026-04-30 Buy
Sigma-Aldrich 799106 2-Hydroxypropyl methacrylamide 99% (GC) 21442-01-3 5g $294 2026-04-30 Buy
TCI Chemical H1770 N-(2-Hydroxypropyl)methacrylamide min. 98.0 % 21442-01-3 5G $122 2026-04-30 Buy
TCI Chemical H1770 N-(2-Hydroxypropyl)methacrylamide min. 98.0 % 21442-01-3 25G $400 2026-04-30 Buy
ChemScene CS-0115777 N-(2-Hydroxypropyl)methacrylamide ≥98% 21442-01-3 1g $9 2026-06-04 Buy
Product number Packaging Price Buy
ANV00013 1G $197 Buy
799106 5g $294 Buy
H1770 5G $122 Buy
H1770 25G $400 Buy
CS-0115777 1g $9 Buy

N-(2-Hydroxypropyl)methacrylamide Chemical Properties,Uses,Production

Description

N-(2-hydroxypropyl)methacrylamide (HPMA) is an important hydrophilic monomer. Due to the non-toxic, non-immunogenic properties and prolonged circulation time of both its homopolymers and copolymers, it is widely employed in the preparation of PHPMA copolymers (a polymer-drug conjugate) for use in the biopharmaceutical industry. For instance, poly(HPMA-co-MA-GFLG-doxorubicin) represents the first intravenous tumour-targeting polymeric prodrug to enter clinical trials. HPMA polymers and copolymers are also employed in the fabrication of biocompatible medical materials such as hydrogels[1].

Uses

Monomers to synthesize biocompetible polymers and copolymers for drug carriers, protein conjugates and hydrogels in biomedical applications.

in vivo

At 5 mg/kg body weight drug equivalent dose, all N-(2-Hydroxypropyl)methacrylamide copolymer-drug conjugates which contained lysosomally degradable side chains shows significant in vivo antileishmanial activity (>99% inhibition)[1].

References

[1] NGUYEN N H, RODRIGUEZ-EMMENEGGER C, BRYNDA E, et al. SET-LRP of N-(2-hydroxypropyl)methacrylamide in H2O†[J]. Polymer Chemistry, 2013, 8: 2424-2427. DOI:10.1039/C3PY00220A.

N-(2-Hydroxypropyl)methacrylamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-(2-Hydroxypropyl)methacrylamide Suppliers

Global( 113)Suppliers
Supplier Tel Email Country ProdList Advantage
Creasyn Finechem(Tianjin) Co., Ltd. 022-83946278 13820372920 sales@creasyn.com China 968 68
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Hunan Hui Bai Shi Biotechnology Co., Ltd. 0731-85526065 13308475853 ivy@hnhbsj.com China 7236 62
TOKYO CHEMICAL INDUSTRY CO., LTD. 03-36680489 Sales-JP@TCIchemicals.com Japan 28364 80
TCI Europe 320-37350700 sales@tcieurope.eu Europe 23654 75
Huainan Kedi Chemical Factory 0554-2106669 sales1@kedichem.com China 4914 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Chengdu HuaXia Chemical Reagent Co. Ltd 400-1166-196 13458535857 cdhxsj@163.com China 13323 58
Finetech Industry Limited 027-87465837 19945049750 sales@finetechnology-ind.com China 9331 58
Supplier Advantage
Creasyn Finechem(Tianjin) Co., Ltd. 68
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Beijing HwrkChemical Technology Co., Ltd 55
Hunan Hui Bai Shi Biotechnology Co., Ltd. 62
TOKYO CHEMICAL INDUSTRY CO., LTD. 80
TCI Europe 75
Huainan Kedi Chemical Factory 55
Bide Pharmatech Ltd. 60
Chengdu HuaXia Chemical Reagent Co. Ltd 58
Finetech Industry Limited 58

View Lastest Price from N-(2-Hydroxypropyl)methacrylamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-(2-HYDROXYPROPYL)METHACRYLAMIDE pictures 2026-08-25 N-(2-HYDROXYPROPYL)METHACRYLAMIDE
21442-01-3
 $2.00-5.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
N-(2-Hydroxypropyl)methacrylamide pictures 2026-07-16 N-(2-Hydroxypropyl)methacrylamide
21442-01-3
 $29.00 99.87% 10g TargetMol Chemicals Inc.
N-(2-Hydroxypropyl)methacrylamide pictures 2026-07-15 N-(2-Hydroxypropyl)methacrylamide
21442-01-3
 $29.00 99.87% 10g TargetMol Chemicals Inc.

N-(2-Hydroxypropyl)methacrylamide Spectrum

N-(2-HYDROXYPROPYL)METHACRYLAMIDE(21442-01-3)MSN-(2-HYDROXYPROPYL)METHACRYLAMIDE(21442-01-3)1HNMR

21442-01-3(N-(2-Hydroxypropyl)methacrylamide)Related Search:

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N-(2-Hydroxypropyl)-2-methyl-prop-2-enamide N-(2-Hydroxypropyl)-2-methyl-prop-2-enamide AldrichCPR 2-Hydroxypropyl methacrylamide 99% (GC) 2-Hydroxypropyl methacrylamide 2-Propenamide,N-(2-hydroxypropyl)-2-methyl- N-(2-HYDROXYPROPYL)METHACRYLAMID High purity CAS 21442-01-3 N-(2-HYDROXYPROPYL)METHACRYLAMIDE in stock DK667 DK668 N(2Hydroxypropyl)methacrylamide,leishmaniasis,N (2 Hydroxypropyl)methacrylamide,agents,Inhibitor,Visceral,inhibit,antileishmanial,copolymers,delivery,synthesize N-(2-Hydroxypropyl)methacrylamide,98% N - (2-hydroxypropyl) methylacrylamide DKFELEX0166 N-(2-Hydroxypropyl)methacrylamide, 10 mM in DMSO N-(2-Hydroxypropyl)methacrylamide 21442-01-3 monomer