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2-(3-Fluorophenyl)thiazole-5-carbaldehyde

2-(3-Fluorophenyl)thiazole-5-carbaldehyde Structure
2-(3-Fluorophenyl)thiazole-5-carbaldehyde structure
CAS No.
914348-84-8
Chemical Name:
2-(3-Fluorophenyl)thiazole-5-carbaldehyde
Synonyms
2-(3-Fluorophenyl)thiazole-5-carbaldehyde;2-(3-Fluorophenyl)-5-thiazolecarboxaldehyde;5-Thiazolecarboxaldehyde, 2-(3-fluorophenyl)-;2-(3-fluorophenyl)-1,3-thiazole-5-carbaldehyde
CBNumber:
CB6454869
Molecular Formula:
C10H6FNOS
Molecular Weight:
207.22
MDL Number:
MFCD06797772
MOL File:
914348-84-8.mol
MSDS File:
SDS
Last updated:2026-09-12 18:54:16
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2-(3-Fluorophenyl)thiazole-5-carbaldehyde Properties

Boiling point 356.9±48.0 °C(Predicted)
Density 1.351±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 0.20±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

2-(3-Fluorophenyl)thiazole-5-carbaldehyde price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 071669 2-(3-Fluorophenyl)thiazole-5-carbaldehyde 914348-84-8 1.00g $347 2026-05-18 Buy
Matrix Scientific 071669 2-(3-Fluorophenyl)thiazole-5-carbaldehyde 914348-84-8 5.00g $898 2026-05-18 Buy
Matrix Scientific 071669 2-(3-Fluorophenyl)thiazole-5-carbaldehyde 914348-84-8 10.00g $1339 2026-05-18 Buy
aablocks AA00GUIU 2-(3-FLUOROPHENYL)THIAZOLE-5-CARBALDEHYDE 95.00% 914348-84-8 50mg $148 2026-05-28 Buy
aablocks AA00GUIU 2-(3-FLUOROPHENYL)THIAZOLE-5-CARBALDEHYDE 95.00% 914348-84-8 100mg $202 2026-05-28 Buy
Product number Packaging Price Buy
071669 1.00g $347 Buy
071669 5.00g $898 Buy
071669 10.00g $1339 Buy
AA00GUIU 50mg $148 Buy
AA00GUIU 100mg $202 Buy

2-(3-Fluorophenyl)thiazole-5-carbaldehyde Chemical Properties, Uses, Production

Synthesis

2-Bromo-5-fomylthiazole

464192-28-7

3-Fluorophenylboronic acid

768-35-4

2-(3-FLUOROPHENYL)THIAZOLE-5-CARBALDEHYDE

914348-84-8

Step 1: Synthesis of 2-(3-fluorophenyl)thiazole-5-carboxaldehyde: To a mixed solution of 2-bromo-5-formylthiazole (0.6 g, 3.125 mmol) in toluene (2 mL) and ethanol (1 mL) was added 3-fluorophenylboronic acid (0.524 g, 3.75 mmol) and 2M aqueous sodium carbonate (in appropriate amount) under argon protection. Subsequently, tetrakis(triphenylphosphine)palladium (0.180 g, 0.156 mmol) was added, and the reaction mixture was again degassed with argon for 10 minutes and heated at 120 °C for 4 hours. After completion of the reaction, ethanol was removed by vacuum evaporation, the reaction mixture was diluted with water (10 mL) and extracted with ethyl acetate (50 mL). The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by Biotage Isolera fast chromatography system (eluent: 6% ethyl acetate/hexane) to afford the target compound 2-(3-fluorophenyl)thiazole-5-carboxaldehyde (0.350 g, 54% yield). The product was characterized as follows: 1H NMR (400 MHz, DMSO-d6) δ 8.78 (s, 1H), 7.90 (dd, 2H), 7.61 (q, 1H), 7.44 (t, 1H); LC-MS m/z calculated value [M + H]+ 208.02, measured value 208.0.

References

[1] Patent: WO2013/49565, 2013, A1. Location in patent: Page/Page column 31

2-(3-Fluorophenyl)thiazole-5-carbaldehyde Preparation Products And Raw materials

Raw materials

2-Bromo-5-fomylthiazole 3-Fluorophenylboronic acid Sodium carbonate Tetrakis(triphenylphosphine)palladium Water
Toluene Ethanol

1of2

Preparation Products

2-(3-Fluorophenyl)thiazole-5-carbaldehyde Suppliers

Global Suppliers ( 26)
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
Hubei Jusheng Technology Co.,Ltd 027-59599241 18871490274 1400878000@qq.com China 9506 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Sichuan BoYou Biotechnology Co., Ltd. 028-65791793 18140026355 568470422@qq.com China 9961 58
Capot Chemical Co.,Ltd. +86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Aikon International Limited 025-66061636 19370895928 qqyang@aikonchem.com China 15810 58
Career Henan Chemica Co +86-0371-86658258 +86-13203830695 laboratory@coreychem.com China 30203 58
Young&Lively Pharminblock Co,.Ltd. 18600731423 jason_gao@yl-pharminblock.com China 1951 58
Supplier Advantage
Capot Chemical Co., Ltd 66
Pure Chemistry Scientific Inc. 62
Shanghai Ennopharm Co., Ltd. 65
Hubei Jusheng Technology Co.,Ltd 58
Amadis Chemical Company Limited 58
Sichuan BoYou Biotechnology Co., Ltd. 58
Capot Chemical Co.,Ltd. 60
Aikon International Limited 58
Career Henan Chemica Co 58
Young&Lively Pharminblock Co,.Ltd. 58

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2-(3-fluorophenyl)-1,3-thiazole-5-carbaldehyde 5-Thiazolecarboxaldehyde, 2-(3-fluorophenyl)- 2-(3-Fluorophenyl)-5-thiazolecarboxaldehyde 2-(3-Fluorophenyl)thiazole-5-carbaldehyde 914348-84-8