2,4-Difluoro-3-methylbenzoic acid
- CAS No.
- 112857-68-8
- Chemical Name:
- 2,4-Difluoro-3-methylbenzoic acid
- Synonyms
- 2,4-Difluoro-3-methylbenzoic acid;Benzoic acid, 2,4-difluoro-3-Methyl-
- CBNumber:
- CB6463193
- Molecular Formula:
- C8H6F2O2
- Molecular Weight:
- 172.13
- MDL Number:
- MFCD03265223
- MOL File:
- 112857-68-8.mol
- MSDS File:
- SDS
| Boiling point | 253.1±35.0 °C(Predicted) |
|---|---|
| Density | 1.359±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 3.28±0.10(Predicted) |
| CAS DataBase Reference | 112857-68-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
2,4-Difluoro-3-methylbenzoic acid price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FD104884 | 2,4-difluoro-3-methylbenzoic Acid | 112857-68-8 | 1g | $900 | 2026-06-04 | Buy |
| Biosynth | FD104884 | 2,4-difluoro-3-methylbenzoic Acid | 112857-68-8 | 0.5g | $900 | 2026-06-04 | Buy |
| Biosynth | FD104884 | 2,4-difluoro-3-methylbenzoic Acid | 112857-68-8 | 0.25g | $900 | 2026-06-04 | Buy |
| Biosynth | FD104884 | 2,4-difluoro-3-methylbenzoic Acid | 112857-68-8 | 5g | $900 | 2026-06-04 | Buy |
| Biosynth | FD104884 | 2,4-difluoro-3-methylbenzoic Acid | 112857-68-8 | 2g | $900 | 2026-06-04 | Buy |
2,4-Difluoro-3-methylbenzoic acid Chemical Properties,Uses,Production
Synthesis
74-88-4
1583-58-0
112857-68-8
1. To a stirred solution of diisopropylamine (1.7 g, 16.4 mmol) in anhydrous THF (30 mL) was slowly added a 2.6 M solution of n-butyllithium (n-BuLi, 1.1 g, 16.4 mmol) under nitrogen protection, the reaction temperature was maintained at -30 °C, and stirring was continued for 1 h at this temperature. 2. The reaction system was cooled to -78 °C and a solution of anhydrous THF (10 mL) of 2,4-difluorobenzoic acid (1.0 g, 6.3 mmol) was added slowly and dropwise, followed by the addition of iodomethane (2.2 g, 15.7 mmol). 3. The reaction mixture was gradually warmed to 50 °C and stirred at this temperature for 2 hours. 4. Upon completion of the reaction, the mixture was returned to room temperature and the reaction was quenched with saturated aqueous ammonium chloride (NH4Cl) solution. 5. The aqueous layer was separated and extracted with ethyl acetate (3 x 25 mL). The organic phases were combined and dried over anhydrous sodium sulfate (Na2SO4). 6. Concentrate under reduced pressure to remove the solvent, and the resulting crude product was purified by silica gel column chromatography, the eluent being a solvent mixture of ethyl acetate/petroleum ether. 7. The target fraction was collected and concentrated under reduced pressure to give a white solid product, 2,4-difluoro-3-methylbenzoic acid (0.77 g, 70% yield). 8. The product was characterized by mass spectrometry (ESI) m/z: 172 [M+H]+, corresponding to the molecular formula C8H6F2O2; 1H NMR (400 MHz, CDCl3) δ: 2.2 (s, 3H), 7.0 (m, 1H), 7.9 (m, 1H).
References
[1] Patent: WO2010/43893, 2010, A1. Location in patent: Page/Page column 99-100
2,4-Difluoro-3-methylbenzoic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai yirong biology science and technology co., ltd | 18049974220 | 3060526242@qq.com | China | 999 | 60 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| HBCChem, Inc. | +1-510-219-6317 | sales@hbcchem.com | United States | 10628 | 60 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| Shanghai Xingui Biotechnology Co., Ltd. | 15121041756 | xingui2022@126.com | China | 9985 | 58 |
View Lastest Price from 2,4-Difluoro-3-methylbenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-10 | 2,4-DIFLUORO-3-METHYLBENZOIC ACID
112857-68-8
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 2,4-DIFLUORO-3-METHYLBENZOIC ACID
112857-68-8
- $1.00
- 99%
- Career Henan Chemical Co
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