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(R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID

(R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID structure

CAS No.: 53558-93-3

Chemical Name:: (R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID

Synonyms: (R)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID;5-oxo-2-tetrahydrofurancarboxylic acid;(theta)-2-furancarboxylicaci;(r)-γ-carboxy-γ-butyrolactone;5-Oxo-tetrahydro-furan-2-carboxylic;(2R)-5-Oxooxolane-2β-carboxylic acid;(R)-(-)-5-OXO-2-TETRAHYDROFUROIC ACID;(R)-GAMMA-CARBOXY-GAMMA-BUTYROLACTONE;(2R)-Tetrahydro-5-Oxo-2-Furan Carboxy;(R)-(-)-GAMMA-CARBOXY-GAMMA-BUTYROLACTONE

CBNumber:: CB6492559

Molecular Formula:: C5H6O4

Molecular Weight:: 130.1

MDL Number:: MFCD00011567

MOL File:: 53558-93-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:44

Product description	Number	Pack Size	Price
(R)-(?)-5-Oxo-2-tetrahydrofurancarboxylic acid 98%	310476	1g	$111
(R)-(?)-5-Oxo-2-tetrahydrofurancarboxylic acid 98%	310476	5g	$320
(R)-(-)-5-Oxotetrahydrofuran-2-carboxylic Acid >98.0%(GC)(T)	O0281	1g	$28
(R)-(-)-5-Oxotetrahydrofuran-2-carboxylic Acid >98.0%(GC)(T)	O0281	5g	$93
(R)-(-)-5-Oxotetrahydrofuran-2-carboxylic Acid	O870405	1g	$65

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(R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID Properties

Melting point	71-73 °C (lit.)
alpha	-14°(D/20℃) (c=5, メタノール)
Boiling point	165-167 °C/0.3 mmHg (lit.)
Density	1.3985 (rough estimate)
refractive index	1.5800 (estimate)
storage temp.	Inert atmosphere,Room Temperature
pka	3.11±0.20(Predicted)
form	solid
Appearance	White to light yellow Solid
optical activity	[α]20/D 14°, c = 5 in methanol
BRN	1424499
InChI	InChI=1S/C5H6O4/c6-4-2-1-3(9-4)5(7)8/h3H,1-2H2,(H,7,8)/t3-/m1/s1
InChIKey	QVADRSWDTZDDGR-GSVOUGTGSA-N
SMILES	O1C(=O)CC[C@@H]1C(O)=O
CAS DataBase Reference	53558-93-3(CAS DataBase Reference)
EPA Substance Registry System	2-Furancarboxylic acid, tetrahydro-5-oxo-, (2R)- (53558-93-3)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

TSCA

TSCA listed

HS Code

29321900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

(R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	310476	(R)-(?)-5-Oxo-2-tetrahydrofurancarboxylic acid 98%	53558-93-3	1g	$111	2026-04-30	Buy
Sigma-Aldrich	310476	(R)-(?)-5-Oxo-2-tetrahydrofurancarboxylic acid 98%	53558-93-3	5g	$320	2026-04-30	Buy
TCI Chemical	O0281	(R)-(-)-5-Oxotetrahydrofuran-2-carboxylic Acid >98.0%(GC)(T)	53558-93-3	1g	$28	2026-04-30	Buy
TCI Chemical	O0281	(R)-(-)-5-Oxotetrahydrofuran-2-carboxylic Acid >98.0%(GC)(T)	53558-93-3	5g	$93	2026-04-30	Buy
TRC	O870405	(R)-(-)-5-Oxotetrahydrofuran-2-carboxylic Acid	53558-93-3	1g	$65	2021-12-16	Buy

Product number	Packaging	Price	Buy
310476	1g	$111	Buy
310476	5g	$320	Buy
O0281	1g	$28	Buy
O0281	5g	$93	Buy
O870405	1g	$65	Buy

(R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Uses

(R)-5-Oxotetrahydrofuran-2-carboxylic Acid is an intermediate used to synthesize 2'',3''-dideoxy-4''-selenonucleosides as potential antiviral agents.

General Description

(R)-()-5-Oxo-2-tetrahydrofurancarboxylic acid belongs to the class of furans, considered as heterocyclic building blocks. It is used as an HPLC derivatization reagent for UV/Vis detection.

Synthesis

6893-26-1

(R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID

53558-93-3

Example 1: Synthesis of (R)-(-)-5-oxo-2-tetrahydrofuran carboxylic acid (2) 1. To a mixed solution of D-glutamic acid (1 , 25 g, 170 mmol) in water (67 mL) and concentrated hydrochloric acid (35 mL) was slowly added a solution of NaNO2 (17.5 g, 253.6 mmol) in water (37.5 mL) at 0 °C for 4 hours. 2. After the addition was completed, the reaction mixture was stirred overnight at room temperature to obtain a clarified solution. 3. The solvent was removed by vacuum evaporation and the residue was treated with ethyl acetate (EtOAc, 80 mL) and filtered. 4. The filtrate was dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated. 5. The concentrated residue was crystallized from a solvent mixture of ethyl acetate/benzene/hexane to afford (R)-(-)-5-oxo-2-tetrahydrofuran carboxylic acid (2) as a white crystalline solid (12.63 g, 57% yield). Product Characterization: - Melting point: 71-73°C - 1H NMR (400 MHz, CD3OD): δ 4.20 (m, 1H, CHO), 1.8-2.3 (m, 4H, CH2CH2).

References

[1] Tetrahedron, 2006, vol. 62, # 37, p. 8687 - 8695
[2] Tetrahedron: Asymmetry, 1993, vol. 4, # 6, p. 1391 - 1396
[3] Organic Letters, 2014, vol. 16, # 16, p. 4336 - 4339
[4] Pharmazie, 1995, vol. 50, # 1, p. 15 - 21
[5] Patent: US2004/67877, 2004, A1

(R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID synthesis

Synthesis of (R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID from 2-Ketoglutaric acid

(R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

D(-)-Glutamic acid Hydrochloric acid Water Ethyl acetate Sodium nitrite

Preparation Products

(R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID Suppliers

Global( 128)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaoxing Fangxiao Chemical Co., LTD	+86-13456999252 +86-13868192239	kenny@fangxiaochem.com	China	50	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29819	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Hangzhou Huarong Pharm Co., Ltd.	571-86758373 +8613588754946	sales@huarongpharm.com	CHINA	3148	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24597	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	+86-0512-83500002 +8618662433356	3899766280@qq.com	China	26362	58

Supplier	Advantage
Shaoxing Fangxiao Chemical Co., LTD	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Hangzhou Huarong Pharm Co., Ltd.	58
Labnetwork lnc.	58
HANGZHOU LEAP CHEM CO., LTD.	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	58

View Lastest Price from (R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-09-03	(R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID 53558-93-3	US $1.00 / KG	1KG	95-99%	500kg	Career Henan Chemical Co

(R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID
53558-93-3
US $1.00 / KG
95-99%
Career Henan Chemical Co

(R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID Spectrum

(R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID(53558-93-3)¹HNMR (R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID(53558-93-3)IR

53558-93-3((R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID)Related Search:

2-(2-METHOXYPHENYL)-5-OXOTETRAHYDROFURAN-3-CARBOXYLIC ACID (R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID (S)-(+)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID 2,2-DIMETHYL-5-OXOTETRAHYDROFURAN-3-CARBOXYLIC ACID 2-Tetrahydrofuroic acid

(1R)-(+)-CAMPHANIC ACID (S)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID,(S)-(+)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID,5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID 2-(1-Carboxyundecyl)-5-oxotetrahydrofuran-2-carboxylic acid (R)-(-)-GAMMA-ETHOXYCARBONYL-GAMMA-BUTYROLACTONE (3S)-2-(2-METHOXYPHENYL)-5-OXOTETRAHYDROFURAN-3-CARBOXYLIC ACID

4-METHYLENE-2-OCTYL-5-OXOTETRAHYDROFURAN-3-CARBOXYLIC ACID 3,4,4-Trimethyl-2-oxotetrahydrofuran-3-carboxylic acid ethyl ester 2-[[(4S)-4-[[Cyanoacetyl]amino]-3-oxotetrahydroisoxazol]-2-yl]-5-oxotetrahydrofuran-2-carboxylic acid sodium salt 2-[[(4S)-4-[[Phenyl-sodiosulfoacetyl]amino]-3-oxotetrahydroisoxazol]-2-yl]-5-oxotetrahydrofuran-2-carboxylic acid sodium salt D-CAMPHANIC ACID ANHYDRIDE

CAMPHANIC ACID 2-[[(4S)-4-[[2-Thienylacetyl]amino]-3-oxotetrahydroisoxazol]-2-yl]-5-oxotetrahydrofuran-2-carboxylic acid sodium salt 2-[[(4S)-4-[[2-Pyridinylthioacetyl]amino]-3-oxotetrahydroisoxazol]-2-yl]-5-oxotetrahydrofuran-2-carboxylic acid sodium salt

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(R)-(-)-GAMMA-CARBOXY-GAMMA-BUTYROLACTONE (R)-GAMMA-CARBOXY-GAMMA-BUTYROLACTONE (R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID (R)-(-)-5-OXO-2-TETRAHYDROFURANCARBOXYLIC ACID (R)-(-)-5-OXO-2-TETRAHYDROFUROIC ACID (R)-(-)-TETRAHYDRO-5-OXO-2-FURANECARBOXYLIC ACID (R)-(-)-5-OXO-2-TETRAHYDROFURANCARBOXYLI C ACID, 98% (97% EE/GLC) (R)-5-OXOTETRAHYDRO-2-FURANCARBOXYLIC ACID 98+% (R)-(-)-5-Oxo-2-tetrahydrofurancarboxylic acid, 99% (99% ee) (R)-(-)-5-Oxotetrahydrofuran-2-carboxylic Acid (theta)-2-furancarboxylicaci D-5-OXO-2-TETRAHYDROFURANCARBOXYLIC ACID (R-) (R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC (r)-γ-carboxy-γ-butyrolactone (R)-5-Oxotetrahydro-2-furancarboxylic acid,(R)-γ-Carboxy-γ-butyrolactone (R)-()-5-Oxo-2-tetrahydrofurancarboxylic acid,(R)-γ-Carboxy-γ-butyrolactone, (R)-5-Oxotetrahydro-2-furancarboxylic acid 2-Furancarboxylic acid,tetrahydro-5-oxo-, (2R) (R)-(-)-5-Oxo-2-tetrahydrofurancarboxylic acid, 99% (99% ee) 1GR (R)-(-)-gamma-Carboxy-gamma-butyrolactone (R)-(-)-5-Oxo-2-tetrahydrofuroic Acid 5-Oxo-tetrahydro-furan-2-carboxylic 2-Furancarboxylic acid, tetrahydro-5-oxo-,(S)- 5-oxo-2-tetrahydrofurancarboxylic acid (R)-γ-Carboxy-γ-butyrolactone, (R)-5-Oxotetrahydro-2-furancarboxylic acid (R)-(-)-5-Oxo-2-tetrahydrofurancarboxylic acid, 99%, ee:.99% (2R)-5-Oxooxolane-2β-carboxylic acid (R)-Tetrahydro-5-oxo-2β-furancarboxylic acid (R)-(-)-5-Oxo-2-tetrahydrofurancarboxylic acid 98% (2R)-Tetrahydro-5-oxo-2-furancarboxylic Acid (R)-(-)-5-Oxotetrahydrofuran-2-carboxylicAcid> (2R)-Tetrahydro-5-Oxo-2-Furan Carboxy (2R)-5-oxotetrahydrofuran-2-carboxylic acid (R)-(?)-5-Oxo-2-tetrahydrofurancarboxylic acid (2R)-5-Oxotetrahydro-2-furancarboxylic acid (R)-tetrahydro-5-oxo-2-furancarboxylic acid (R)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID 53558-93-3 CARBOXYLIC ACID Chiral Building Blocks Carboxylic Acids (Chiral) Asymmetric Synthesis Chiral Resolution Reagents Chiral Resolving Reagents Heterocyclic Building Blocks Furans Carboxylic Acids (Chiral) Chiral Building Blocks Synthetic Organic Chemistry