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tert-Butyl 4-hydroxybutyrate

tert-Butyl 4-hydroxybutyrate Structure
tert-Butyl 4-hydroxybutyrate structure
CAS No.
59854-12-5
Chemical Name:
tert-Butyl 4-hydroxybutyrate
Synonyms
tert-butyl 4-hydroxybutanoate;4-Hydroxy-butyric acid tert-butyl ester;2-(2-hydroxyethyl)-3,3-dimethylbutanoate;tert-butyl 4-hydroxybutanoate - [B87055];Butanoic acid, 4-hydroxy-, 1,1-diMethylethyl ester
CBNumber:
CB6497327
Molecular Formula:
C8H16O3
Molecular Weight:
160.21
MDL Number:
MFCD02684391
MOL File:
59854-12-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:54:17
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tert-Butyl 4-hydroxybutyrate Properties

Boiling point 73-74 °C(Press: 2.0-3.0 Torr)
Density 0.976 g/mL at 20 °C
refractive index n20/D 1.431
Flash point >70℃
storage temp. Refrigerator
solubility Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
form Oil
pka 14.86±0.10(Predicted)
color Colourless to Pale Yellow
InChI InChI=1S/C8H16O3/c1-8(2,3)11-7(10)5-4-6-9/h9H,4-6H2,1-3H3
InChIKey RXGFTUPFXKYRMW-UHFFFAOYSA-N
SMILES C(OC(C)(C)C)(=O)CCCO

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
HS Code  2915601990

tert-Butyl 4-hydroxybutyrate price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AstaTech 56650 TERT-BUTYL-4-HYDROXYBUTYRATE 97% 59854-12-5 0.25G $54 2026-04-30 Buy
AstaTech 56650 TERT-BUTYL-4-HYDROXYBUTYRATE 97% 59854-12-5 1G $118 2026-04-30 Buy
AstaTech 56650 TERT-BUTYL-4-HYDROXYBUTYRATE 97% 59854-12-5 5G $349 2026-04-30 Buy
Biosynth FB157013 tert-Butyl 4-hydroxybutyrate 59854-12-5 1g $302.19 2026-06-04 Buy
Biosynth FB157013 tert-Butyl 4-hydroxybutyrate 59854-12-5 2g $447.7 2026-06-04 Buy
Product number Packaging Price Buy
56650 0.25G $54 Buy
56650 1G $118 Buy
56650 5G $349 Buy
FB157013 1g $302.19 Buy
FB157013 2g $447.7 Buy

tert-Butyl 4-hydroxybutyrate Chemical Properties, Uses, Production

Uses

tert-Butyl 4-Hydroxybutanoate is used as a reagent in the synthesis of theranostic vitamin-linker-taxoid conjugates. tert-Butyl 4-Hydroxybutanoate is also used as a reagent in the synthesis of teroxazoles as α-helix mimetics.

Synthesis

Mono-tert-butyl succinate

15026-17-2

TERT-BUTYL 4-HYDROXYBUTYRATE

59854-12-5

General procedure for the synthesis of tert-butyl 4-hydroxybutyrate from mono-tert-butyl succinate: BH3-Me2S (2.0 M solution in THF, 6.6 mL, 13.1 mmol) was slowly added dropwise to a solution of mono-tert-butyl succinate (2.12 g, 12.2 mmol) in anhydrous THF (20 mL) that was cooled to 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 24 hours. Upon completion of the reaction, EtOAc (100 mL) was added for dilution and the organic layer was separated. The organic layer was washed sequentially with water (70 mL) and saturated saline (70 mL) and dried with anhydrous MgSO4. After filtration, the solvent was removed by concentration under reduced pressure to afford tert-butyl 4-hydroxybutyrate (1.92 g, 12.2 mmol, quantitative yield), the product was a light yellow oil, which could be used in the subsequent reaction without further purification.

References

[1] Tetrahedron, 2014, vol. 70, # 44, p. 8343 - 8347
[2] Bioconjugate Chemistry, 2010, vol. 21, # 5, p. 979 - 987
[3] Beilstein Journal of Organic Chemistry, 2017, vol. 13, p. 2428 - 2441
[4] Journal of Organic Chemistry, 2003, vol. 68, # 17, p. 6679 - 6684
[5] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 18, p. 4004 - 4009

tert-Butyl 4-hydroxybutyrate synthesis

15026-17-2
59854-12-5
Synthesis of tert-Butyl 4-hydroxybutyrate from Mono-tert-butyl succinate

tert-Butyl 4-hydroxybutyrate Preparation Products And Raw materials

Raw materials

Butanoic acid, 4-chloro-4-oxo-, 1,1-dimethylethyl ester Butanoic acid, 4-(acetyloxy)-, 1,1-dimethylethyl ester Butanoic acid, 4-(phenylmethoxy)-, 1,1-dimethylethyl ester tert-Butyl methyl succinate 97 tert-butyl 3-hydroxybutanoate
Mono-tert-butyl succinate Tetrahydrofuran Borane-methyl sulfide complex

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Preparation Products

tert-Butyl 4-hydroxybutyrate Suppliers

Global Suppliers ( 132)
Supplier Tel Email Country ProdList Advantage
Shaanxi Yikunte Pharmaceutical Technology Co., Ltd. 18049260030 18049260030 380381031@qq.com China 492 58
Wuhan EEChem Technologies Co., Ltd 0711-3617768 13308685235 lihongcai4360@sina.com China 1542 55
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Cuisen Pharmaceutical Technology Co., Ltd. 13472757003 yongnan.wang@cendrix.cn China 971 65
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. +86-28-85122536 85324413 market@astatech.cn China 8016 55
Shanghai Chainpharm Bio-medical Technology Co., Ltd. +86-021-61727342 13611721451 sales@chainpharm.com China 984 58
Supplier Advantage
Shaanxi Yikunte Pharmaceutical Technology Co., Ltd. 58
Wuhan EEChem Technologies Co., Ltd 55
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
Adamas Reagent, Ltd. 59
Accela ChemBio Co.,Ltd. 64
Shanghai Cuisen Pharmaceutical Technology Co., Ltd. 65
Hangzhou Sage Chemical Co., Ltd. 58
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. 55
Shanghai Chainpharm Bio-medical Technology Co., Ltd. 58

View Latest Price from tert-Butyl 4-hydroxybutyrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TERT-BUTYL 4-HYDROXYBUTYRATE pictures 2019-12-25 TERT-BUTYL 4-HYDROXYBUTYRATE
59854-12-5
 $1.00 1KG 99% 200kg Career Henan Chemical Co

tert-Butyl 4-hydroxybutyrate Spectrum

TERT-BUTYL 4-HYDROXYBUTYRATE(59854-12-5)1HNMRTERT-BUTYL 4-HYDROXYBUTYRATE(59854-12-5)FT-IR

59854-12-5 (tert-Butyl 4-hydroxybutyrate) Related Search:

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D-Aspartic acid 4-tert-butyl ester Boc-L-aspartic acid 4-tert-butyl ester Fmoc-D-Aspartic acid beta-tert-butyl ester Fmoc-Asp(OtBu)-OH L-Fmoc-Aspartic acid alpha-tert-butyl ester
4-tert-Butyl N-[(tert-butoxy)carbonyl]-L-aspartate dicyclohexylamine salt L-Aspartic acid 4-tert-butyl ester Boc-Asp(OtBu)-OSu Fmoc-Asp(OtBu)-OPfp N-alpha-Benzyloxycarbonyl-L-aspartic acid alpha-tert-butyl ester dicyclohexylamine
Boc-D-Asp(OtBu)-OH dcha Boc-Asp(OtBu)-ONp L-Aspartic acid di-tert-butyl ester dibenzenesulfimide salt

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2-(2-hydroxyethyl)-3,3-dimethylbutanoate Butanoic acid, 4-hydroxy-, 1,1-diMethylethyl ester 4-Hydroxy-butyric acid tert-butyl ester tert-butyl 4-hydroxybutanoate - [B87055] tert-butyl 4-hydroxybutanoate 59854-12-5