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Boc-L-aspartic acid 4-tert-butyl ester

Boc-L-aspartic acid 4-tert-butyl ester structure

CAS No.: 1676-90-0

Chemical Name:: Boc-L-aspartic acid 4-tert-butyl ester

Synonyms: BOC-ASP(OTBU)-OH;BOC-L-ASP(OTBU)-OH;BOC-L-ASP(TBU)-OH;BOC-ASP(OBUT)-OH;L-BOC-ASP(OTBU)-OH;Boc-L-Asp(OtBu)-0H;Boc-L-Asp(Otbu)-OH >98%;BOC-ASPARTIC ACID(OTBU)-OH;4-tert-Butyl N-Boc-L-aspartate;(Tert-Butoxy)Carbonyl Asp(OtBu)-OH

CBNumber:: CB5485550

Molecular Formula:: C13H23NO6

Molecular Weight:: 289.33

MDL Number:: MFCD00076912

MOL File:: 1676-90-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:15:24

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Boc-L-aspartic acid 4-tert-butyl ester Properties

Melting point	64-67 °C
alpha	2 º (c=1% in MeOH)
Boiling point	432.6±40.0 °C(Predicted)
Density	1.139±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Soluble in methanol and dimethyl sulfoxide.
form	Powder
pka	3.69±0.23(Predicted)
color	White
optical activity	[α]20/D +2.0±0.4°, c = 1% in methanol
BRN	2336144
Major Application	peptide synthesis
InChI	InChI=1S/C13H23NO6/c1-12(2,3)19-9(15)7-8(10(16)17)14-11(18)20-13(4,5)6/h8H,7H2,1-6H3,(H,14,18)(H,16,17)/t8-/m0/s1
InChIKey	PHJDCONJXLIIPW-QMMMGPOBSA-N
SMILES	C(O)(=O)[C@H](CC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O
CAS DataBase Reference	1676-90-0(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H335-H315-H319

Precautionary statements

P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

PPE

Eyeshields, Gloves, type N95 (US)

Safety Statements

24/25

WGK Germany

HazardClass

IRRITANT

HS Code

29241990

Storage Class

11 - Combustible Solids

NFPA 704

	0
0		0

Boc-L-aspartic acid 4-tert-butyl ester price More Price(75)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	15429	Boc-Asp(OtBu)-OH ≥99.0% (sum of enantiomers, TLC)	1676-90-0	1g	$143	2026-04-30	Buy
Sigma-Aldrich	15429	Boc-Asp(OtBu)-OH ≥99.0% (sum of enantiomers, TLC)	1676-90-0	5G	$593	2026-04-30	Buy
TCI Chemical	B3935	4-tert-Butyl N-(tert-Butoxycarbonyl)-L-aspartate >98.0%(HPLC)(T)	1676-90-0	1g	$26	2026-04-30	Buy
TCI Chemical	B3935	4-tert-Butyl N-(tert-Butoxycarbonyl)-L-aspartate >98.0%(HPLC)(T)	1676-90-0	5g	$126	2026-04-30	Buy
Usbiological	264201	Boc-L-aspartic acid 4-tert-butyl ester Asreported	1676-90-0	10g	$199	2026-06-03	Buy

Product number	Packaging	Price	Buy
15429	1g	$143	Buy
15429	5G	$593	Buy
B3935	1g	$26	Buy
B3935	5g	$126	Buy
264201	10g	$199	Buy

Boc-L-aspartic acid 4-tert-butyl ester Chemical Properties, Uses, Production

Uses

It is used in the preparation of highly selective thrombin inhibitors. Also used in the preparation of thiopeptides and thioacylating agents.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

3057-74-7

1676-90-0

2.1. Preparation of Boc-Asp(O-tBu)-NCA (II-a) The method involves the main chain cyclization of a free carboxylic acid in which the amine functional group is protected by Boc. First, (Boc)2-Asp(Ot-Bu)-OH (VII-a) needs to be prepared. The specific steps are as follows: 1. esterify the α-carboxylic acid of Boc-Asp(Ot-Bu)-OH (Va) to benzyl ester (VI-a). 2. reaction with Boc2O in the presence of DMAP to give the bis-Boc-protected amino compound (VII-a). 3. removal of the benzyl ester protecting group by hydrogenation to give (VIII-a). Subsequent steps include cyclization with Vilsmeier salt protected amino acid (VIII-a). The optimum reaction conditions were in acetonitrile with the salt formed from DMF and oxalyl chloride. The final compound (II-a) was obtained in 90% yield.

References

[1] Patent: US2010/16631, 2010, A1. Location in patent: Page/Page column 5-6
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 15, p. 4975 - 4978
[3] Patent: WO2017/24009, 2017, A1. Location in patent: Paragraph 0652
[4] Russian Journal of Bioorganic Chemistry, 1999, vol. 25, # 5, p. 283 - 287
[5] Bioorganicheskaya Khimiya, 1999, vol. 25, # 5, p. 323 - 328

Boc-L-aspartic acid 4-tert-butyl ester Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate L-Aspartic acid 4-tert-butyl ester 1,4-Dioxane Water Triethylamine

Preparation Products

L-Aspartic acid hydrochloride

Boc-L-aspartic acid 4-tert-butyl ester Suppliers

Global Suppliers ( 273)

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Yuye Biotechnology Co., Ltd.	17826523762	3437309915@qq.com	China	81	58
Shanghai Boyle Chemical Co., Ltd.	021-50182298 021-50180596	sales@boylechem.com	China	2202	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66

Supplier	Advantage
Nanjing Yuye Biotechnology Co., Ltd.	58
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
GL Biochem (Shanghai) Ltd	64
Capot Chemical Co., Ltd	66

View Latest Price from Boc-L-aspartic acid 4-tert-butyl ester manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-15	Boc-L-Asp(Otbu)-OH 1676-90-0	1kg	98%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2026-09-15	Boc-Asp(OtBu)-OH 1676-90-0	1KG	98%min	500kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2022-02-10	Boc-Asp(otBu)-OH 1676-90-0	1KG	98.7%	100 tons	Honest Joy Holdings Limited

Boc-L-Asp(Otbu)-OH
1676-90-0
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

Boc-Asp(OtBu)-OH
1676-90-0
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Boc-Asp(otBu)-OH
1676-90-0
$0.00
98.7%
Honest Joy Holdings Limited

Boc-L-aspartic acid 4-tert-butyl ester Spectrum

Boc-L-aspartic acid 4-tert-butyl ester(1676-90-0)¹HNMR

1676-90-0 (Boc-L-aspartic acid 4-tert-butyl ester) Related Search:

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1of4

4-[(2-methylpropan-2-yl)oxy]-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-4-oxobutanoic acid N-Boc-L-aspartic acid 4-tert-butyl ester, 98% N-tert-Butyloxycarbonyl-L-aspartic Acid β-tert-Butyl Ester BOC-L-ASP(TBU)-OH BOC-L-ASPARTIC ACID-BETA-T-BUTYL ESTER BOC-L-ASPARTIC ACID 4-TERT-BUTYL ESTER BOC-ASP(OBUT)-OH BOC-ASPARTIC ACID(OTBU)-OH Boc-L-aspartic acid ?-tert-butyl ester99% 4-tert-Butyl N-(tert-Butoxycarbonyl)-L-aspartate N-(tert-Butoxycarbonyl)-L-aspartic Acid 4-tert-Butyl Ester 4-tert-Butyl N-Boc-L-aspartate N-Boc-L-aspartic Acid 4-tert-Butyl Ester Boc-Asp(OtBu)-OH (2S)-4-tert-butoxy-2-[(tert-butoxycarbonyl)aMino]-4-oxobutanoic acid N-ALPHA-T-BOC-L-ASPARTIC ACID BETA-T-BUTYL ESTER N-ALPHA-T-BUTOXYCARBONYL-L-ASPARTIC ACID-BETA-T-BUTYL ESTER N-ALPHA-T-BUTOXYCARBONYL-L-ASPARTIC ACID-4-T-BUTYL ESTER N-ALPHA-T-BUTYLOXYCARBONYL-L-ASPARTIC ACID BETA-T-BUTYL ESTER N-ALPHA-TERT-BUTYLOXYCARBONYL-L-ASPARTIC ACID BETA-TERT-BUTYL ESTER (S)-4-tert-butoxy-2-(tert-butoxycarbonylamino)-4-oxobutanoic acid Boc-L-aspartic acid-beta-tert-butyl ester L-BOC-ASP(OTBU)-OH (Tert-Butoxy)Carbonyl Asp(OtBu)-OH 4-tert-Butyl N-(tert-Butoxycarbonyl)-L-aspartate > tert-Butyloxycarbonyl-L-aspartic acid 4-tert-butyl ester L-Aspartic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 4-(1,1-dimethylethyl) ester 4-tert-Butyl N-Boc-L-aspartate BOC-L-ASPARTIC ACID 4-TERT-BUTYL ESTER 1676-90-0 Boc-L-aspartic acid 4-tert-butyl ester USP/EP/BP Boc-L-aspartic acid β-tert-butyl ester Tert-butoxycarbonyl -L- aspartic acid -4- tert-butyl ester Tert butoxycarbonyl L-aspartate 4-tert butyl ester Boc-L-aspartate 4-tert-butyl ester Boc-L-Asp(OtBu)-0H Boc-L-Asp(Otbu)-OH >98% BOC-L-ASP(OTBU)-OH BOC-ASP(OTBU)-OH N-tert-Butyloxycarbonyl-L-aspartic Acid b-tert-Butyl Ester N-Boc-L-aspartic acid 4-tert-butyl ester 1676-90-0 16761-08-5 CH33COCOCH2CHCOOHNHCOOCCH33 Specialty Synthesis Peptide Synthesis Amino Acid Derivatives Aspartic Acid Aspartic acid [Asp, D] Boc-Amino Acids and Derivative Boc-Amino acid series