Cyclizine Hydrochloride
- CAS No.
- 303-25-3
- Chemical Name:
- Cyclizine Hydrochloride
- Synonyms
- Cyclizine HCl solution;Collox;Echnatol;Fortravel;CYCLYZINE HCL;Einecs 206-136-9;cyclizinechloride;marezinehydrochloride;CYCLIZINE HYDROCHLORIDE;Cyclizini hydrochloridum
- CBNumber:
- CB6500522
- Molecular Formula:
- C18H23ClN2
- Molecular Weight:
- 302.84162
- MDL Number:
- MFCD00023293
- MOL File:
- 303-25-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 258-260℃ |
|---|---|
| Boiling point | 457.04°C (rough estimate) |
| Density | 1.0551 (rough estimate) |
| refractive index | 1.5749 (estimate) |
| storage temp. | Refrigerator |
| solubility | Methanol: 1 mg/ml |
| form | solid |
| Major Application |
pharmaceutical pharmaceutical small molecule |
| InChI | 1S/C18H22N2.ClH/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18H,12-15H2,1H3;1H |
| InChIKey | UKPBEPCQTDRZSE-UHFFFAOYSA-N |
| SMILES | [Cl-].N3(CCN(CC3)C)C(c2ccccc2)c1ccccc1.[H+] |
| FDA 21 CFR | 336.10 |
| FDA UNII | W0O1NHP4WE |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 61-23/24/25-42/43 | |||||||||
| Safety Statements | 53-22-36/37/39-45 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933595960 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
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| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| Toxicity | mouse,LD50,intraperitoneal,58mg/kg (58mg/kg),Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 13, Pg. 241, 1975. | |||||||||
| NFPA 704 |
|
Cyclizine Hydrochloride price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C3090000 | Cyclizine hydrochloride (European Pharmacopoeia (EP) Reference Standard) | 303-25-3 | 50 mg | $254 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1154004 | Cyclizine hydrochloride | 303-25-3 | 200mg | $417 | 2026-04-30 | Buy |
| Sigma-Aldrich | C3090000 | Cyclizine hydrochloride (European Pharmacopoeia (EP) Reference Standard) | 303-25-3 | c3090000 | $220 | 2024-03-01 | Buy |
| Sigma-Aldrich | C-231 | Cyclizine HCl solution 1?mg/mL in methanol ((as free base)), certified reference material, ampule of 1?mL, Cerilliant? | 303-25-3 | 1ML | $106 | 2022-05-15 | Buy |
| Sigma-Aldrich | C3090000 | Cyclizine hydrochloride (European Pharmacopoeia (EP) Reference Standard) | 303-25-3 | $190 | 2021-12-16 | Buy |
Cyclizine Hydrochloride Chemical Properties, Uses, Production
Chemical Properties
Off-White Solid
moderately soluble in water
Originator
Marezine,BurroughsWellcome,US,1953
Uses
Cyclizine Hydrochloride is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. Antiemetic.
Uses
Motion sickness (prophylaxis and treatment)—Oral cyclizine is indicated for the prophylaxis and treatment of nausea, vomiting, and dizziness associated with motion sickness. Nausea and vomiting, postoperative (prophylaxis and treatment)—to prevent or reli
Definition
ChEBI: Cyclizine hydrochloride is a hydrochloride salt consisting of equimolar amounts of cyclizine and hydrogen chloride. It has a role as a H1-receptor antagonist, a central nervous system depressant, a cholinergic antagonist and an antiemetic. It contains a cyclizine.
Manufacturing Process
One-tenth mol (20 g) of benzhydryl chloride was mixed with 0.19 mol (19 g) of N-methylpiperazine and about 10 cc of benzene and the whole was heated on the steam bath four hours. The contents of the flask was partitioned between ether and water, and the ethereal layer was washed with water until the washings were neutral. The base was then extracted from the ethereal layer by N hydrochloric acid and the extract, made acid to Congo red paper, was evaporated under vacuum. 29.5 g of the pure dihydrochloride of Nmethyl-N'-benzhydryl piperazine was recovered from the residue by recrystallization from 95% alcohol melting above 250°C with decomposition. The addition of alkali to an aqueous solution of the dihydrochloride liberated the base which was recovered by recrystallization from petroleum ether melting at 105.5° to 107.5°C.
Therapeutic Function
Antinauseant
Cyclizine Hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29975 | 65 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8039 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Jai Radhe Sales | +(91)-(79)-26431096/65255722 | info@jairadhesales.com | India | 394 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 18916372613 | yanzihan@shyuanye.com | China | 87240 | 60 |
View Latest Price from Cyclizine Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-10-10 | Cyclizine Hydrochloride
303-25-3
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2021-07-02 | Cyclizine Hydrochloride
303-25-3
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-01-10 | Cyclizine Hydrochloride
303-25-3
|
$1.00 | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- Cyclizine Hydrochloride
303-25-3
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Cyclizine Hydrochloride
303-25-3
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Cyclizine Hydrochloride
303-25-3
- $1.00
- ≥98%
- Career Henan Chemical Co
