Cyclizine
- CAS No.
- 82-92-8
- Chemical Name:
- Cyclizine
- Synonyms
- CYCLIZINE HCL;Valoid;Emoquil;bw47-83;Marzine;Bw 47-83;Marazine;Marezine;Wellcome;Ciclizina
- CBNumber:
- CB5336795
- Molecular Formula:
- C18H22N2
- Molecular Weight:
- 266.38
- MDL Number:
- MFCD00067334
- MOL File:
- 82-92-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1-(DIPHENYLMETHYL)-4-METHYLPIPERAZINE AldrichCPR | S361267 | 1 unit | $197 |
| 1-(DIPHENYLMETHYL)-4-METHYLPIPERAZINE AldrichCPR | S361267 | 250MG | $179 |
| Cyclizine 98.20% | CS-0013123 | 5mg | $272 |
| Cyclizine 98.20% | CS-0013123 | 10mg | $422 |
| Cyclizine 98.20% | CS-0013123 | 25mg | $682 |
| Melting point | 105.5-107.5° |
|---|---|
| Boiling point | 399.58°C (rough estimate) |
| Density | 0.9934 (rough estimate) |
| refractive index | 1.5840 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Slightly soluble in water and in ethanol (96 per cent). |
| form | Solid |
| color | White to off-white |
| EWG's Food Scores | 1 |
| FDA UNII | QRW9FCR9P2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H319-H301-H335-H315 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P310-P321-P330-P405-P501 |
| Hazardous Substances Data | 82-92-8(Hazardous Substances Data) |
Cyclizine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S361267 | 1-(DIPHENYLMETHYL)-4-METHYLPIPERAZINE AldrichCPR | 82-92-8 | 1 unit | $197 | 2026-04-30 | Buy |
| Sigma-Aldrich | S361267 | 1-(DIPHENYLMETHYL)-4-METHYLPIPERAZINE AldrichCPR | 82-92-8 | 250MG | $179 | 2024-03-01 | Buy |
| ChemScene | CS-0013123 | Cyclizine 98.20% | 82-92-8 | 5mg | $272 | 2026-06-04 | Buy |
| ChemScene | CS-0013123 | Cyclizine 98.20% | 82-92-8 | 10mg | $422 | 2026-06-04 | Buy |
| ChemScene | CS-0013123 | Cyclizine 98.20% | 82-92-8 | 25mg | $682 | 2026-06-04 | Buy |
Cyclizine Chemical Properties,Uses,Production
Chemical Properties
White or almost white, crystalline powder.
Originator
Marezine,BurroughsWellcome,US,1953
Uses
H1 antihistamine
Uses
Cyclizine exhibits antihistamine and anticholinergic action and is used for vomiting and diarrhea. The exact mechanism of action is not known. Synonyms of this drug are marezine and migril.
Uses
Cyclizine is an antihistamine with a sedative effect used in the treatment of nausea and vomiting associated with motion sickness.
Preparation
Cyclizine is prepared through the alkylation of N-methylpiperazine with benzhydryl chloride.
Definition
ChEBI: An N-alkylpiperazine in which one nitrogen of the piperazine ring is substituted by a methyl group, while the other is substituted by a diphenylmethyl group.
Manufacturing Process
One-tenth mol (20 g) of benzhydryl chloride was mixed with 0.19 mol (19 g) of N-methylpiperazine and about 10 cc of benzene and the whole was heated on the steam bath four hours. The contents of the flask was partitioned between ether and water, and the ethereal layer was washed with water until the washings were neutral. The base was then extracted from the ethereal layer by N hydrochloric acid and the extract, made acid to Congo red paper, was evaporated under vacuum. 29.5 g of the pure dihydrochloride of Nmethyl-N'-benzhydryl piperazine was recovered from the residue by recrystallization from 95% alcohol melting above 250°C with decomposition. The addition of alkali to an aqueous solution of the dihydrochloride liberated the base which was recovered by recrystallization from petroleum ether melting at 105.5° to 107.5°C.
brand name
Marezine (GlaxoSmithKline).
Therapeutic Function
Antinauseant
General Description
Cyclizine hydrochloride,1-(diphenylmethyl)-4-methylpiperazine monohydrochloride(Marezine), occurs as a light-sensitive, white crystallinepowder with a bitter taste. It is slightly soluble in water(1:115), in alcohol (1:115), and in chloroform (1:75). It isused primarily in the prophylaxis and treatment of motionsickness. The lactate salt (Cyclizine Lactate Injection,United States Pharmacopoeia [USP]) is used for intramuscular(IM) injection because of the limited water solubilityof the hydrochloride. The injection should be stored in acold place, because if it is stored at room temperature forseveral months, a slight yellow tint may develop. This doesnot indicate a loss in biologic potency.
Clinical Use
It can be used not only in the treatment of allergic diseases, but also in the management of postoperative, irradiation or druginduced vomiting. Cyclizine dependence has been suggested to occur when it is used in combination with analgesics in long-term therapy. For this reason, several countries have removed cyclicine from analgesic combination preparations.
Synthesis
Cyclizine, 1-(diphenylmethyl)-4-methylpiperazine (16.1.15), is synthesized by alkylating 1-methylpiperazine with benzhydrylbromide.
Cyclizine Preparation Products And Raw materials
Cyclizine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15083 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9414 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-18712993135 | sales01@tairunfaz.com | China | 8051 | 58 |
| Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | Ryan@jiutian-bio.com | China | 5945 | 58 |
