BIOTIN HPDP
- CAS No.
- 129179-83-5
- Chemical Name:
- BIOTIN HPDP
- Synonyms
- HPDP-Biotin;Biotin Impurity 31;Pyridyldithiol-biotin;Biotin HPDP,BiotinHPDP;Pyridyldisulfide-biotin;Ciprofibrate Impurity 6;Biotin-HPDP, 10 mM in DMSO;Macamide Impurity 11(Biotin HPDP);Biotin-HPDP, Sulfhydryl-reactive biotinylation reagent;N-[6-(Biotinamido)hexyl]-3’-(2-pyridyldithio)propionamide
- CBNumber:
- CB6500704
- Molecular Formula:
- C24H37N5O3S3
- Molecular Weight:
- 539.78
- MDL Number:
- MFCD00078541
- MOL File:
- 129179-83-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 160-163°C |
|---|---|
| Boiling point | 876.0±65.0 °C(Predicted) |
| Density | 1.28 |
| storage temp. | -20°C Freezer |
| solubility | insoluble in H2O; ≥101.4 mg/mL in DMSO; ≥8.29 mg/mL in EtOH with ultrasonic |
| form | powder to crystal |
| pka | 13.90±0.40(Predicted) |
| color | White to Light yellow |
| InChIKey | QLPHBNRMJLFRGO-YDHSSHFGSA-N |
| SMILES | C1(=O)N[C@]2([H])[C@H](CCCCC(NCCCCCCNC(=O)CCSSC3=NC=CC=C3)=O)SC[C@]2([H])N1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| WGK Germany | WGK 3 |
|---|---|
| HS Code | 2934.99.4400 |
| Storage Class | 11 - Combustible Solids |
BIOTIN HPDP price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B5749 | Biotin-HPDP | 129179-83-5 | 25MG | $86 | 2026-04-30 | Buy |
| TCI Chemical | B5749 | Biotin-HPDP | 129179-83-5 | 100MG | $237 | 2026-04-30 | Buy |
| Cayman Chemical | 16459 | Biotin-HPDP ≥95% | 129179-83-5 | 5mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 16459 | Biotin-HPDP ≥95% | 129179-83-5 | 10mg | $68 | 2026-04-30 | Buy |
| Cayman Chemical | 16459 | Biotin-HPDP ≥95% | 129179-83-5 | 50mg | $253 | 2026-04-30 | Buy |
BIOTIN HPDP Chemical Properties,Uses,Production
Description
Biotin-HPDP is a sulfhydryl-reactive biotinylation reagent that forms a reversible disulfide linkage. It is used to label protein cysteines and other substrates that contain sulfhydryl groups. Biotin-HPDP is also used in the biotin switch technique to tag S-nitrosylated (SNO) proteins, following reduction of SNO groups to thiols. Compounds that are tagged with biotin interact avidly with streptavidin-coupled beads, fluorophores, enzymes, etc. The interaction of biotin-HPDP with substrates containing sulfhydryl groups is easily performed at pH 6.5 to 7.5 in buffers such as PBS. The disulfide linkage that is formed between avidin and substrate can later by cleaved by a reducing agent, like dithiothreitol.
Chemical Properties
Pale Yellow Solid
Uses
This compounds reacts specifically with thiol groups.
Application
Mustafa et al. applied S-methylmethanethiosulfonate (MMTS) and N-(6-(biotinamido)hexyl)-3′-(2′-pyridyldithio)propionamide (BIOTIN HPDP) to detect protein polysulfidation. The assumption was that MMTS exclusively blocks −SH, while BIOTIN HPDP can tag −SSH[6].
References
[1] CHANGYUAN LU. S-sulfhydration/desulfhydration and S-nitrosylation/denitrosylation: A common paradigm for gasotransmitter signaling by H2S and NO[J]. Methods, 2013, 62 2: Pages 177-181. DOI: 10.1016/j.ymeth.2013.05.020
[2] S. SLATIN. Translocation of a functional protein by a voltage-dependent ion channel[J]. Proceedings of the National Academy of Sciences of the United States of America, 2002, 99 1: 1286-1291. DOI: 10.1073/pnas.022480199
[3] OSCAR A. BIZZOZERO Jianzheng Z. Identification of major S-nitrosylated proteins in murine experimental autoimmune encephalomyelitis[J]. Journal of Neuroscience Research, 2009, 87 13: 2881-2889. DOI: 10.1002/jnr.22113
[4] KARINA CKLESS . In situ detection and visualization of S-nitrosylated proteins following chemical derivatization: identification of Ran GTPase as a target for S-nitrosylation[J]. Nitric oxide: biology and chemistry, 2004, 11 3: Pages 216-227. DOI: 10.1016/j.niox.2004.06.002
[5] MICHAEL T FORRESTER Jonathan S S Matthew W Foster. Assessment and application of the biotin switch technique for examining protein S-nitrosylation under conditions of pharmacologically induced oxidative stress.[J]. The Journal of Biological Chemistry, 2007, 282 19: 13977-13983. DOI: 10.1074/jbc.m609684200
[6] Yuping Xin. (2025). Detection of Protein Polysulfidation Using a β-(4-Hydroxyphenyl)ethyl Iodoacetamide-Derived Biotin Tag HPB. Analytical Chemistry, 53 89 1. https://doi.org/10.1021/acs.analchem.5c00712
BIOTIN HPDP Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HINOVA PHARMACEUTICALS INC. | 18244267397 | cxinghua127@163.com | China | 129 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
View Lastest Price from BIOTIN HPDP manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-07 | Biotin-HPDP
129179-83-5
|
250mg | >95.00% | 250mg | Xian confluore Biological Technology Co., Ltd. |
-
- Biotin-HPDP
129179-83-5
- $0.00
- >95.00%
- Xian confluore Biological Technology Co., Ltd.
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