YZ129
- CAS No.
- 1643120-60-8
- Chemical Name:
- YZ129
- Synonyms
- YZ129;4-(Isoquinolin-6-ylamino)naphthalene-1,2-dione;1,2-Naphthalenedione, 4-(6-isoquinolinylamino)-;YZ129 4-(Isoquinolin-6-ylamino)naphthalene-1,2-dione
- CBNumber:
- CB65540367
- Molecular Formula:
- C19H12N2O2
- Molecular Weight:
- 300.31
- MDL Number:
- MFCD31813767
- MOL File:
- 1643120-60-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
YZ129 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2640 | YZ129 ≥98% (HPLC) | 1643120-60-8 | 5MG | $91.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2640 | YZ129 ≥98% (HPLC) | 1643120-60-8 | 25MG | $296 | 2026-04-30 | Buy |
| ChemScene | CS-0084986 | YZ129 99.85% | 1643120-60-8 | 5mg | $65 | 2026-06-04 | Buy |
| ChemScene | CS-0084986 | YZ129 99.85% | 1643120-60-8 | 10mg | $108 | 2026-06-04 | Buy |
| ChemScene | CS-0084986 | YZ129 99.85% | 1643120-60-8 | 25mg | $238 | 2026-06-04 | Buy |
YZ129 Chemical Properties, Uses, Production
Uses
YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration[1].
IC 50
HSP90
References
[1] Liu Z, et al. Discovery of Small-Molecule Inhibitors of the HSP90-Calcineurin-NFAT Pathway against Glioblastoma. Cell Chem Biol. 2018 Nov 30. pii: S2451-9456(18)30431-8. DOI:10.1016/j.chembiol.2018.11.009
YZ129 Preparation Products And Raw materials
Raw materials
Preparation Products
YZ129 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 975 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | 024-88590548 18698872706 | 757984502@qq.com | China | 960 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 4000862158 18117107507 | vip@med-life.cn | China | 4999 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
