19,21-Dinorchol-4-en-20(22)-yn-3-one, 17-hydroxy-23,23-dimethyl-11-[4-[methyl(1-methylethyl)amino]phenyl]-, (11β,17α)-
![19,21-Dinorchol-4-en-20(22)-yn-3-one, 17-hydroxy-23,23-dimethyl-11-[4-[methyl(1-methylethyl)amino]phenyl]-, (11β,17α)- Structure](CAS/20211123/GIF/2222344-98-9.gif)
- CAS No.
- 2222344-98-9
- Chemical Name:
- 19,21-Dinorchol-4-en-20(22)-yn-3-one, 17-hydroxy-23,23-dimethyl-11-[4-[methyl(1-methylethyl)amino]phenyl]-, (11β,17α)-
- Synonyms
- ORIC101,ORIC 101;19,21-Dinorchol-4-en-20(22)-yn-3-one, 17-hydroxy-23,23-dimethyl-11-[4-[methyl(1-methylethyl)amino]phenyl]-, (11β,17α)-
- CBNumber:
- CB65566385
- Molecular Formula:
- C34H47NO2
- Molecular Weight:
- 501.76
- MDL Number:
- MFCD32062751
- MOL File:
- 2222344-98-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
19,21-Dinorchol-4-en-20(22)-yn-3-one, 17-hydroxy-23,23-dimethyl-11-[4-[methyl(1-methylethyl)amino]phenyl]-, (11β,17α)- Properties
| Boiling point | 640.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.11±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| form | Solid |
| pka | 12.82±0.60(Predicted) |
| color | White to off-white |
| FDA UNII | VI6E2D3CYP |
19,21-Dinorchol-4-en-20(22)-yn-3-one, 17-hydroxy-23,23-dimethyl-11-[4-[methyl(1-methylethyl)amino]phenyl]-, (11β,17α)- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | XND34498 | ORIC-101 | 2222344-98-9 | 25mg | $2355.75 | 2026-06-05 | Buy |
| ChemScene | CS-0062840 | ORIC-101 99.62% | 2222344-98-9 | 1mg | $672 | 2026-06-04 | Buy |
| ChemScene | CS-0062840 | ORIC-101 99.62% | 2222344-98-9 | 5mg | $2004 | 2026-06-04 | Buy |
| ChemScene | CS-0062840 | ORIC-101 99.62% | 2222344-98-9 | 10mg | $3250 | 2026-06-04 | Buy |
| ChemScene | CS-0062840 | ORIC-101 99.62% | 2222344-98-9 | 25mg | $5200 | 2026-06-04 | Buy |
19,21-Dinorchol-4-en-20(22)-yn-3-one, 17-hydroxy-23,23-dimethyl-11-[4-[methyl(1-methylethyl)amino]phenyl]-, (11β,17α)- Chemical Properties, Uses, Production
Uses
ORIC-101 is a highly potent and selective glucocorticoid receptor antagonist, with an EC50 of 5.6 nM. Anti-cancer activity. ORIC-101 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
in vivo
ORIC-101 (75 mg/kg, P.O. twice a day for 16-22 days) enhances the anti-tumor activity in combination with gemcitabine and carboplatin in OVCAR5 xenograft tumor in cortisol-treated mice[1].
| Animal Model: | OVCAR5 xenograft tumor in cortisol-treated mice[1] |
| Dosage: | 75 mg/kg with 100 mg/kg gemcitabine and 60 mg/kg carboplatin |
| Administration: | P.O. twice a day for 16-22 days |
| Result: | Significantly reduced tumor volume in combination with chemotherapeutic agents. |
References
[1] Rew Y, et al. Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101). J Med Chem. 2018 Sep 13;61(17):7767-7784. DOI:10.1021/acs.jmedchem.8b00743
19,21-Dinorchol-4-en-20(22)-yn-3-one, 17-hydroxy-23,23-dimethyl-11-[4-[methyl(1-methylethyl)amino]phenyl]-, (11β,17α)- Preparation Products And Raw materials
Raw materials
Preparation Products
19,21-Dinorchol-4-en-20(22)-yn-3-one, 17-hydroxy-23,23-dimethyl-11-[4-[methyl(1-methylethyl)amino]phenyl]-, (11β,17α)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15727060112 | yutianchun2007@126.com | China | 9867 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 4000862158 18117107507 | vip@med-life.cn | China | 4999 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| Zhejiang Huida Biotech Co., Ltd. | 0571-89903022 18679456698 | zilong@hizyme.com | China | 7853 | 58 |
