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CORTEXOLONE

CORTEXOLONE structure

CAS No.: 152-58-9

Chemical Name:: CORTEXOLONE

Synonyms: 11-DEOXYCORTISOL;CORTODOXONE;Deoxycortisol;11-DEOXY-17-HYDROXYCORTICOSTERONE;11-DESOXYCORTISOL;11-deoxyhydrocortisone;11-desoxyhydrocortisone;17,21-DIHYDROXYPROGESTERONE;17-hydroxy-11-deoxycorticosterone;4-Pregnene-17a,21-diol-3,20-dione

CBNumber:: CB0493958

Molecular Formula:: C21H30O4

Molecular Weight:: 346.46

MDL Number:: MFCD00003662

MOL File:: 152-58-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

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CORTEXOLONE Properties

Melting point	205-208 °C
Boiling point	401.19°C (rough estimate)
Density	1.22±0.1 g/cm3 (20 ºC 760 Torr)
refractive index	120 ° (C=1, Dioxane)
Flash point	9℃
storage temp.	Sealed in dry,Room Temperature
solubility	Dioxane (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly, Heated)
form	Solid
pka	12+-.0.60(Predicted)
color	White to Off-White
Water Solubility	44.08mg/L(37 ºC)
Merck	14,2932
Major Application	diagnostic assay manufacturing hematology histology
InChI	InChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1
InChIKey	WHBHBVVOGNECLV-OBQKJFGGSA-N
SMILES	C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@](O)(C(=O)CO)CC3)CC2
CAS DataBase Reference	152-58-9(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	WDT5SLP0HQ
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS02,GHS06,GHS08
Signal word	Danger
Hazard statements	H225-H301+H311+H331-H370
Precautionary statements	P210-P260-P280-P301+P310-P311
PPE	Eyeshields, Gloves, type N95 (US)
Hazard Codes	F,T
Risk Statements	11-23/24/25-39/23/24/25
Safety Statements	24/25-22-45-36/37-16-7
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS	TU5011500
HS Code	2937.23.5050
Storage Class	11 - Combustible Solids
Toxicity	mouse,LD50,intravenous,100mg/kg (100mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04684,

CORTEXOLONE price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	R200050	17-ALPHA,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE Aldrich^CPR	152-58-9	1 unit	$32.7	2026-04-30	Buy
Sigma-Aldrich	R0500	Reichstein’s substance S ≥98%	152-58-9	1g	$63.9	2026-04-30	Buy
Sigma-Aldrich	D-061	11-Deoxycortisol solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?	152-58-9	1mL	$152	2026-04-30	Buy
Sigma-Aldrich	R200050	17-ALPHA,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE AldrichCPR	152-58-9	1MG	$29.8	2024-03-01	Buy
TCI Chemical	C1478	Cortexolone >98.0%(HPLC)	152-58-9	1g	$220	2026-04-30	Buy

Product number	Packaging	Price	Buy
R200050	1 unit	$32.7	Buy
R0500	1g	$63.9	Buy
D-061	1mL	$152	Buy
R200050	1MG	$29.8	Buy
C1478	1g	$220	Buy

CORTEXOLONE Chemical Properties, Uses, Production

Chemical Properties

Crystalline Solid

Uses

11-Deoxy Cortisol (Hydrocortisone EP Impurity F) is a glucocorticoid receptor binding.

Definition

ChEBI: 11-deoxycortisol is a deoxycortisol that is cortisol in which the hydroxy group at position 11 has been replaced by a hydrogen. It has a role as a mouse metabolite and a human metabolite. It is a glucocorticoid, a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone and a deoxycortisol.

in vivo

Cortodoxone (100 mg/kg; i.p.) increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone^[1].

Animal Model:	220-320g, adult male Wistar rats^[2]
Dosage:	100 mg/kg
Administration:	IP
Result:	Increased tryptophan oxygenase (TO) activity and induced the secretion of corticosterone.

IC 50

Human Endogenous Metabolite

CORTEXOLONE Preparation Products And Raw materials

Raw materials

Preparation Products

17,20:20,21-Bis(Methylenedioxy)pregn-4-en-3-one

CORTEXOLONE Suppliers

Global Suppliers ( 293)

Supplier	Tel	Email	Country	ProdList	Advantage
Chongqing Chemieliva Pharmaceutical Co., Ltd.	18696571988	amy.lei@chemieliva.com	China	1350	60
Hunan Kaimir Biotechnology Co., Ltd.	0731-+86-0731-89714511 +86-18602659358	sales@chemapi.com.cn	China	35	58
Shanghai Peiling Biological Technology Co., LTD	13127581762 13127581762	peilingchem@sina.com	China	494	58
Hubei Yuanmeng Biological Technology Co., Ltd.	027-68897569 17740516530	1958216756@qq.com	China	2902	58
Jiangsu Baiaoxinkang Pharmaceutical Technology Co. , Ltd.	18015077019 18015077019	jwang@bioscenepharma.com	China	105	58
Nanjing Kuvinos Medical Technology Co., Ltd.	17853099917	847922127@qq.com	China	336	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81

Supplier	Advantage
Chongqing Chemieliva Pharmaceutical Co., Ltd.	60
Hunan Kaimir Biotechnology Co., Ltd.	58
Shanghai Peiling Biological Technology Co., LTD	58
Hubei Yuanmeng Biological Technology Co., Ltd.	58
Jiangsu Baiaoxinkang Pharmaceutical Technology Co. , Ltd.	58
Nanjing Kuvinos Medical Technology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
TCI (Shanghai) Development Co., Ltd.	81

View Latest Price from CORTEXOLONE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-18	Cortexolone 152-58-9		10kg	99.5%	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-02	CORTEXOLONE 152-58-9	$1.00-50.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-07-27	Cortodoxone 152-58-9	$44.00		99.82%	10g	TargetMol Chemicals Inc.

Cortexolone
152-58-9
99.5%
WUHAN FORTUNA CHEMICAL CO., LTD

CORTEXOLONE
152-58-9
$1.00-50.00
99%
Henan Fengda Chemical Co., Ltd

Cortodoxone
152-58-9
$44.00
99.82%
TargetMol Chemicals Inc.

CORTEXOLONE Spectrum

CORTEXOLONE(152-58-9)MS CORTEXOLONE(152-58-9)¹HNMR CORTEXOLONE(152-58-9)¹³CNMR CORTEXOLONE(152-58-9)IR1 CORTEXOLONE(152-58-9)IR2 CORTEXOLONE(152-58-9)Raman

152-58-9 (CORTEXOLONE) Related Search:

11-Deoxycortisol-[D5] Pregn-4-ene-3,20-dione-2,2,4,6,6,21,21,21-d8, 11,17-dihydroxy-, (11β)- 11-Deoxycortisol (21,21-d2, 96%) 11beta,17alpha-Dihydroxy-4-pregnene-3,20-dione 11beta,17alpha-Dihydroxy-4-pregnene-3,20-dione

CORTISONE Hydrocortisone sodium succinate 4-Pregnen-6-beta, 17,21-triol-3,11,20-trione Reichstein's substance S 21-acetate Cortisol 17-valerate

11-alpha-Hydrocortisone Hydrocortisone sodium phosphate Hydrocortisone-17-butyrate Hydrocortisone Cortisone acetate

Flurandrenolide Hydrocortisone 21-hemisuccinate CORTEXOLONE

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(8R,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one Hydrocortisone Impurity 6（Hydrocortisone EP Impurity F） 11-DEOXYCORTISOL; CORTEXOLONE; REICHSTEIN'S SUBSTANCE S 11-dioxy-cortiso 11-dioxycortisol 17,21-dihydroxy-pregn-4-ene-20-dione 17-hydroxy-11-deoxycorticosterone nsc-18317 CORTEXOLONE 17ALPHA,21-DIHYDROXY-4-PREGNENE-3,20-DIONE 17ALPHA,21-DIHYDROXYPREGNA-4-ENE-3,20-DIONE 11-DESOXY-17-HYDROXYCORTICOSTERONE 11-DESOXYCORTISOL Reichstein S 11-Deoxy-17-hydroxycorticosterone, 11-Deoxycortisol, 17α,21-Dihydroxy-4-pregnene-3,20-dione, 17α-Hydroxycortexone, 17,21-Dihydroxy-4-pregnene-3,20-dione, 17,21-Dihydroxyprogesterone, 4-Pregnene-17α,21-diol-3,20-dione, Cortexolone, Reichsteins Compound S ReichsteinSubstanceS 17α,21-Dihydroxypregn-4-ene-3,20-dione Cortexolone,99% Reichstein’s substanceS,11-Deoxy-17-hydroxycorticosterone, 11-Deoxycortisol, 17α,21-Dihydroxy-4-pregnene-3,20-dione, 17α-Hydroxycortexone, 17,21-Dihydroxy-4-pregnene-3,20-dione, 17,21-Dihydroxyproges 11-Deoxy-17-hydroxycorticosterone 17alpha,21-Dihydroxy-4-pregnene-3,20-dione Reichstein's Substance S 4-Pregnen-17a,21-diol-3,20-dione-d2 Pregn-4-ene-3,20-dione, 17,21-dihydroxy- 11-Deoxycortisol solution cortexolone solution,100ppm 17α-Hydroxycortexone 4-Pregnene-17α,21-diol-3,20-dione Hydrocortisone impurity F (EP) Hydrocortisone EP Impurity F 11-deoxyhydrocortisone 11-desoxyhydrocortisone 17ALPHA-HYDROXYCORTEXONE 17,21-DIHYDROXY-4-PREGNENE-3,20-DIONE 17,21-DIHYDROXYPROGESTERONE 4-PREGNENE-17ALPHA,21-DIOL-3,20-DIONE 4-PREGNEN-17,21-DIOL-3,20-DIONE 4-PREGNEN-17A 21-DIOL-3,20-DIONE 4-PREGNEN-17ALPHA,21-DIOL-3,20-DIONE (8R,9S,10R,13S,14S,17R)-17-HYDROXY-17-(2-HYDROXY-ACETYL)-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE REICHSTEIN'S COMPOUND ''S'' REICHSTEIN'S SUBSTANCE S REICHSTEIN'S SUBSTANCE ''S'' REICHSTEIN'S SUBSTANCE 'S' skf3050 11-Desoxycortisone 17alpha,21-Dihydroxypregn-4-ene-3,20-dione 17,21-Dihydroxypregn-4-en-3,20-dione 4-Pregnene-17a,21-diol-3,20-dione 17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one Cortexolone > 17,21-Dihydroxypregn-4-ene-3,20-dio Hydrocortisone EP Impurity F (Reichsteins Substance S) (8R,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl- 152-58-9 CORTEXOLONE 17α,21-dihydroxyprogesterone Deoxycortisol (Solution) Hydrocortisone EP Impurity F (Cortexolone) Cortexolone Clascoterone Intermediate Cortexolone (Hydrocortisone EP Impurity F)