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VU0453379

VU0453379 Structure
VU0453379 structure
CAS No.
1638646-27-1
Chemical Name:
VU0453379
Synonyms
VU0453379;1H-Pyrido[3,4-b]indole-4-carboxamide, 2-cyclopentyl-2,9-dihydro-9-methyl-N-[[(2S)-1-(1-methylethyl)-2-pyrrolidinyl]methyl]-1-oxo-
CBNumber:
CB65838150
Molecular Formula:
C26H34N4O2
Molecular Weight:
434.57
MDL Number:
MFCD28502156
MOL File:
1638646-27-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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VU0453379 Properties

Boiling point 671.8±55.0 °C(Predicted)
Density 1.28±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
pka 13.46±0.20(Predicted)
color Off-white to light yellow
Water Solubility H2O: 20mg/mL, clear
InChIKey OCMGNMGYQPPMFF-FYZYNONXSA-N
SMILES CN1C2=C(C(C(NC[C@@H]3CCCN3C(C)C)=O)=CN(C4CCCC4)C2=O)C5=CC=CC=C51.Cl
UNSPSC Code 51111800
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

VU0453379 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1357 VU0453379 hydrochloride ≥98% (HPLC) 1638646-27-1 25 mg $408 2026-04-30 Buy
Biosynth NQC64627 VU0453379 1638646-27-1 10mg $713.9 2026-06-04 Buy
Biosynth NQC64627 VU0453379 1638646-27-1 25mg $1213.75 2026-06-04 Buy
ChemScene CS-0066597 VU0453379 98.0% 1638646-27-1 5mg $271 2026-06-04 Buy
ChemScene CS-0066597 VU0453379 98.0% 1638646-27-1 10mg $422 2026-06-04 Buy
Product number Packaging Price Buy
SML1357 25 mg $408 Buy
NQC64627 10mg $713.9 Buy
NQC64627 25mg $1213.75 Buy
CS-0066597 5mg $271 Buy
CS-0066597 10mg $422 Buy

VU0453379 Chemical Properties, Uses, Production

Uses

VU0453379 is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM[1].

Biological Activity

VU0453379 is a highly selective CNS penetrant positive allosteric modulator of Glucagon-like peptide-1 (GLP-1) with GLP-1 EC50 = 1.3 μ,M, 59.2% GLP-1 max. VU0453379 potentiated low-dose exenatide to augment insulin secretion in primary mouse pancreatic islets. In a model of Parkinson′s disease it showed a significant reversal of haloperidol-induced catalepsy at 30 mg/kg.

References

[1] Morris LC, et al. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). J Med Chem. 2014 Dec 11;57(23):10192-7. DOI:10.1021/jm501375c

VU0453379 Preparation Products And Raw materials

Raw materials

Preparation Products

VU0453379 Suppliers

Global Suppliers ( 11)
Supplier Tel Email Country ProdList Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
InvivoChem 13549236410 sales@invivochem.cn China 6745 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
https://hanhongsci.com/ 021-54306202 18917919676 info@hanhongsci.com China 29982 58
TargetMol Chemicals Inc. +1-781-999-5354; support@targetmol.com United States 38999 58
Supplier Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
TargetMol Chemicals Inc. 58
InvivoChem 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
https://hanhongsci.com/ 58
TargetMol Chemicals Inc. 58

View Latest Price from VU0453379 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
VU0453379 pictures 2026-07-27 VU0453379
1638646-27-1
 $244.00 10g TargetMol Chemicals Inc.
  • VU0453379 pictures
  • VU0453379
    1638646-27-1
  • $244.00
  • TargetMol Chemicals Inc.

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VU0453379 1H-Pyrido[3,4-b]indole-4-carboxamide, 2-cyclopentyl-2,9-dihydro-9-methyl-N-[[(2S)-1-(1-methylethyl)-2-pyrrolidinyl]methyl]-1-oxo- 1638646-27-1