SR12343
- CAS No.
- 2055101-86-3
- Chemical Name:
- SR12343
- Synonyms
- SR12343;N-(3-Bromophenethyl)-2-((5-chloropyridin-2-yl)amino)acetamide;N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-acetamide;Acetamide, N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-
- CBNumber:
- CB65867455
- Molecular Formula:
- C15H15BrClN3O
- Molecular Weight:
- 368.66
- MDL Number:
- MOL File:
- 2055101-86-3.mol
- MSDS File:
- SDS
SR12343 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 31031 | SR 12343 ≥98% | 2055101-86-3 | 1mg | $66 | 2026-04-30 | Buy |
| Cayman Chemical | 31031 | SR 12343 ≥98% | 2055101-86-3 | 5mg | $165 | 2026-04-30 | Buy |
| Cayman Chemical | 31031 | SR 12343 ≥98% | 2055101-86-3 | 10mg | $264 | 2026-04-30 | Buy |
| Cayman Chemical | 31031 | SR 12343 ≥98% | 2055101-86-3 | 25mg | $578 | 2026-04-30 | Buy |
| Biosynth | FHD10186 | N-(3-Bromophenethyl)-2-((5-chloropyridin-2-yl)amino)acetamide | 2055101-86-3 | 25mg | $1091.5 | 2026-06-04 | Buy |
SR12343 Chemical Properties, Uses, Production
Uses
SR12343, an IKK/NF-κB inhibitor, is a NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic. SR12343 inhibits TNF-α- and LPS-induced NF-κB activation by blocking the interaction between IKKβ and NEMO, with an IC50 of 37.02 μM for TNF-α-mediated NF-κB activation. SR12343 suppresses LPS-induced acute pulmonary inflammation in mice. SR12343 can be used for research of inflammatory and degenerative diseases[1].
Biological Activity
SR 12343 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1 It selectively disrupts the association of NEMO/IKKγ with IKKβ over TNF receptor-associated factor 2 (TRAF2), IκBα, and IKKα in co-immunoprecipitation assays using RAW 264.7 cells at concentrations ranging from 25 to 150 μM. SR 12343 inhibits TNF-α-induced NF-κB activation in a reporter assay. It reduces increased serum IL-6 levels in a mouse model of LPS-induced endotoxemia when administered at a dose of 10 mg/kg. SR 12343 (30 mg/kg) improves grip strength and reduces muscle fibrosis in the mdx mouse model of Duchenne muscular dystrophy.
References
1.Zhao, J., Zhang, L., Mu, X., et al.Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-kB activationPLoS Biol.16(6)e2004663(2018)
SR12343 Preparation Products And Raw materials
Raw materials
Preparation Products
SR12343 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4999 | 58 |
| ChemeGen | 18818260767 | 2625930290@qq.com | China | 6966 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6745 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
