FINO2
- CAS No.
- 869298-31-7
- Chemical Name:
- FINO2
- Synonyms
- FINO2;(5α,8α)-8-(1,1-dimethylethyl)-3-methyl-1,2-dioxaspiro[4.5]decane-3-ethanol;1,2-Dioxaspiro[4.5]decane-3-ethanol, 8-(1,1-dimethylethyl)-3-methyl-, (5α,8α)-
- CBNumber:
- CB66197320
- Molecular Formula:
- C15H28O3
- Molecular Weight:
- 256.38
- MDL Number:
- MOL File:
- 869298-31-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 79-81 °C |
|---|---|
| Boiling point | 323.8±11.0 °C(Predicted) |
| Density | 1.02±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml |
| form | A solid |
| pka | 14.90±0.10(Predicted) |
| color | White to off-white |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|---|---|
| Signal word | Danger |
| Hazard statements | H242 |
| Precautionary statements | P210-P234-P235-P280-P370+P378-P410 |
FINO2 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25096 | FINO2 ≥95% | 869298-31-7 | 1mg | $83 | 2026-04-30 | Buy |
| Cayman Chemical | 25096 | FINO2 ≥95% | 869298-31-7 | 5mg | $207 | 2026-04-30 | Buy |
| Cayman Chemical | 25096 | FINO2 ≥95% | 869298-31-7 | 10mg | $330 | 2026-04-30 | Buy |
| Cayman Chemical | 25096 | FINO2 ≥95% | 869298-31-7 | 25mg | $620 | 2026-04-30 | Buy |
| ChemScene | CS-0105631 | FINO2 98.0% | 869298-31-7 | 1mg | $70 | 2026-06-04 | Buy |
FINO2 Chemical Properties, Uses, Production
Uses
FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation[1].
Definition
ChEBI: FINO2 is an oxaspiro compound that is 1,2-dioxaspiro[4.5]decane substituted by methyl, 2-hydroxyethyl and tert-butyl groups at positions 3, 3 and 8, respectivey (the 5s,8s-stereoisomer). It induces ferroptosis in cancer cells by indirectly inhibiting glutathione peroxidase 4 (GPX4) enzymatic function and directly oxidizes iron leading to widespread lipid peroxidation. It has a role as a ferroptosis inducer and an antineoplastic agent. It is an oxaspiro compound, an organic peroxide, a primary alcohol and an organic heterobicyclic compound.
References
[1] Gaschler MM, et al. FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol. 2018 May;14(5):507-515. DOI:10.1038/s41589-018-0031-6
FINO2 Preparation Products And Raw materials
Raw materials
Preparation Products
FINO2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | +86-0513; 18051384581 | sales@chemhifuture.com | China | 3075 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| Shanghai Taopu Industrial Co., LTD | 15900573766 18018507602 | 3165608826@qq.com | China | 4404 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2934 | 58 |
