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2-Bromo-2′-hydroxyacetophenone

2-Bromo-2′-hydroxyacetophenone Structure
2-Bromo-2′-hydroxyacetophenone structure
CAS No.
2491-36-3
Chemical Name:
2-Bromo-2′-hydroxyacetophenone
Synonyms
2-broMo-1-(2-hydroxyphenyl)ethan-1-one;2-AMINO-3'2-Bromo-2′Cyclohexane Impurity 4;2-HYDROXYPHENACYL BROMIDE;2-BROMO-2'-HYDROXYACETOPHENONE;2-Bromo-2’-hydroxyacetophenone;2-(2-bromoacetyl)hydroxybenzene;2-Bromo-2'-hydroxylacetophenone;2-Bromo-2'-hydroxyacetophenone 97%
CBNumber:
CB6675345
Molecular Formula:
C8H7BrO2
Molecular Weight:
215.04
MDL Number:
MFCD01727570
MOL File:
2491-36-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-04 16:00:12
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2-Bromo-2′-hydroxyacetophenone Properties

Melting point 44-48 °C(lit.)
Boiling point 152-158 °C(Press: 18 Torr)
Density 1.622±0.06 g/cm3(Predicted)
Flash point >230 °F
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Chloroform, Methanol
pka 7.63±0.30(Predicted)
form Solid
color Yellow
Sensitive Lachrymatory
InChI 1S/C8H7BrO2/c9-5-8(11)6-3-1-2-4-7(6)10/h1-4,10H,5H2
InChIKey SGPKEYSZPHMVNI-UHFFFAOYSA-N
SMILES Oc1ccccc1C(=O)CBr
CAS DataBase Reference 2491-36-3(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H314
Precautionary statements  P260-P270-P280-P301+P312-P303+P361+P353-P305+P351+P338
PPE Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  C
Risk Statements  22-34
Safety Statements  26-36/37/39-45
RIDADR  UN 3263 8/PG 2
WGK Germany  3
RTECS  KM5556400
Hazard Note  Corrosive/Lachrymatory/Keep Cold
HazardClass  8
PackingGroup  II
HS Code  29147000
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Acute Tox. 4 Oral
Skin Corr. 1B
Toxicity mouse,LD50,oral,821mg/kg (821mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)LUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 183, 1992.
Limited Quantities 1 Kg (2.2 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
1
3 0

2-Bromo-2′-hydroxyacetophenone price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 594938 2-Bromo-2′-hydroxyacetophenone 97% 2491-36-3 1g $70.5 2022-05-15 Buy
Sigma-Aldrich 594938 2-Bromo-2′-hydroxyacetophenone 97% 2491-36-3 5g $137 2022-05-15 Buy
TCI Chemical B4735 2-Bromo-2'-hydroxyacetophenone 2491-36-3 1G $60 2026-04-30 Buy
TCI Chemical B4735 2-Bromo-2'-hydroxyacetophenone 2491-36-3 5G $181 2026-04-30 Buy
TRC TRC-B684455-500MG 2-Bromo-2’-hydroxyacetophenone 2491-36-3 500mg $148 2026-06-03 Buy
Product number Packaging Price Buy
594938 1g $70.5 Buy
594938 5g $137 Buy
B4735 1G $60 Buy
B4735 5G $181 Buy
TRC-B684455-500MG 500mg $148 Buy

2-Bromo-2′-hydroxyacetophenone Chemical Properties, Uses, Production

Chemical Properties

Off-White Powder

Uses

2-Bromo-2′-hydroxyacetophenone is used as a pharmaceutical intermediate.

Synthesis

2'-Hydroxyacetophenone

118-93-4

2-Bromo-2′-hydroxyacetophenone

2491-36-3

The general procedure for the synthesis of 2-bromo-1-(2-hydroxyphenyl)ethanone from 2'-hydroxyacetophenone is as follows: in a 50 mL round-bottomed flask equipped with a magnetic stirrer, 2'-hydroxyacetophenone (10 mmol) was added. Subsequently, potassium bromide (40 mmol) dissolved in 20 mL of water was added to this solution and mixed with stirring at room temperature. Next, 30% hydrogen peroxide (4 mmol) was slowly added. Vanadium (V) complex (0.01 mmol) and 70% perchloric acid (4 mmol) were further added to the reaction system, and the reaction mixture was stirred at 0°C, followed by raising to room temperature and continued stirring for 10 minutes. Under continuous stirring conditions, additional 70% perchloric acid (4 mmol) was added every 10 min for three times. The reaction process was monitored by thin layer chromatography (TLC). The nuclear magnetic resonance (NMR) spectral data of the final brominated product is detailed in the Supporting Information.

References

[1] Tetrahedron Letters, 2009, vol. 50, # 6, p. 700 - 703
[2] Tetrahedron, 2001, vol. 57, # 11, p. 2203 - 2211
[3] Archiv der Pharmazie, 2009, vol. 342, # 9, p. 541 - 545
[4] Synthetic Communications, 2006, vol. 36, # 19, p. 2877 - 2881
[5] Journal of Organometallic Chemistry, 2018, vol. 876, p. 10 - 16

2-Bromo-2′-hydroxyacetophenone synthesis

582-24-1
2491-36-3
Synthesis of 2-Bromo-2′-hydroxyacetophenone from 2-Hydroxyacetophenone

2-Bromo-2′-hydroxyacetophenone Preparation Products And Raw materials

Raw materials

Bromine Acetic acid 2'-Hydroxyacetophenone Ethanone, 1-[2-(acetyloxy)phenyl]-2-bromo- Phenyl bromoacetate
Potassium bromide Perchloric acid Hydrogen peroxide 2-Hydroxyacetophenone Phenol

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Preparation Products

5-Bromo-2-hydroxyacetophenone 2-Bromo-4'-hydroxyacetophenone 2-Bromo-1-(5-bromo-2-hydroxyphenyl)ethanone 3-(Bromomethyl)-1,2-benzisoxazole 2-Bromo-1-(2-hydroxy-5-nitro-phenyl)-ethanone

2-Bromo-2′-hydroxyacetophenone Suppliers

Global Suppliers ( 155)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Changzhou Huanling Chemical Co., Ltd. 89803005 18206112582 info@huanlingchem.com China 983 68
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Supplier Advantage
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
Changzhou Huanling Chemical Co., Ltd. 68
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
Syntechem Co.,Ltd 57

View Latest Price from 2-Bromo-2′-hydroxyacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromo-2′-hydroxyacetophenone pictures 2026-06-30 2-Bromo-2′-hydroxyacetophenone
2491-36-3
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-BROMO-2'-HYDROXYACETOPHENONE pictures 2025-04-04 2-BROMO-2'-HYDROXYACETOPHENONE
2491-36-3
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

2-Bromo-2′-hydroxyacetophenone Spectrum

2-Bromo-2′-hydroxyacetophenone(2491-36-3)1HNMR

2491-36-3 (2-Bromo-2′-hydroxyacetophenone) Related Search:

3',5'-Dibromo-4'-hydroxyacetophenone w-Bromo-4-Hydroxyacetophenone,OMEGA-BROMO-4-HYDROXYACETOPHENONE 5-Bromo-2-hydroxyacetophenone 2'-BROMO-4'-HYDROXYACETOPHENONE,2-BROMO-4'-HYDROXYACETOPHENONE,ALPHA-BROMO-4-HYDROXYACETOPHENONE,2-Bromo-4-Hydroxyacetophenone98%,α-Bromo-4-hydroxyacetophenone 3'-Bromo-5'-chloro-2'-hydroxyacetophenone
2-Bromo-2'-methoxyacetophenone 2'-Hydroxyacetophenone 3',5'-Dibromo-2'-hydroxyacetophenone 1-(4-Bromophenyl)-2-hydroxyethan-1-one 3-Bromochromone
2-Bromo-2′,4′-dimethoxyacetophenone 2-Bromo-2',5'-dimethoxyacetophenone 4-Bromo-2-hydroxyacetophenone 2-Bromo-3'-hydroxyacetophenone 3'-Bromo-4'-hydroxyacetophenone
2-Bromo-2'-hydroxyacetophenone oxime 2-Bromo-2,3-dihydro-4,7-dimethoxy-1H-inden-1-one 2,3-Dibromo-1-(5-chloro-2-hydroxyphenyl)-3-phenylpropan-1-one

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2-Bromo-2'-hydroxyacetophenone ,97% 2-Bromo-2'-hydroxyacetophenone, 2-Bromo-1-(2-hydroxyphenyl)ethan-1-one, 2-(Bromoacetyl)phenol 2-Bromo-2'-hydroxyacetophenone 97% JR-8498, 2-Bromo-1-(2-hydroxyphenyl)ethanone, 97% 2-bromo-1-(2-hydroxyphenyl)-ethanon 2-HYDROXYPHENACYL BROMIDE 2-BROMO-1-(2-HYDROXYPHENYL)ETHANONE 2-BROMO-2'-HYDROXYACETOPHENONE 2-Bromo-2'-hydroxylacetophenone Ethanone, 2-bromo-1-(2-hydroxyphenyl)- 2-(2-bromoacetyl)hydroxybenzene 2-AMINO-3' 2-Bromo-2’-hydroxyacetophenone 2-Bromo-2′ Cyclohexane Impurity 4 2-broMo-1-(2-hydroxyphenyl)ethan-1-one 2491-36-3 BrCH2COC6H4OH Organic Building Blocks Ketones Building Blocks C7 to C8 Carbonyl Compounds Intermediate of Neticonazole Hydrochloride API intermediates Aromatics C7 to C8 Carbonyl Compounds Ketones