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2-BROMO-2'-METHOXYACETOPHENONE

2-BROMO-2'-METHOXYACETOPHENONE structure

CAS No.: 31949-21-0

Chemical Name:: 2-BROMO-2'-METHOXYACETOPHENONE

Synonyms: 2-BROMO-1-(2-METHOXYPHENYL)ETHANONE;AKOS BBS-00003867;O-METHOXYPHENACYL BROMIDE;2-METHOXYPHENACYL BROMIDE;2'-METHOXYPHENACYL BROMIDE;2-Methoxyphenacylbromide97%;A-BROMO-O-METHOXYACETOPHENONE;2-Methoxyphenacyl bromide 98%;2-BROMO-2'-METHOXYACETOPHENONE;α-Bromo-2'-methoxyacetophenone

CBNumber:: CB4350095

Molecular Formula:: C9H9BrO2

Molecular Weight:: 229.07

MDL Number:: MFCD00000196

MOL File:: 31949-21-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-22 15:57:46

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2-BROMO-2'-METHOXYACETOPHENONE Properties

Melting point	43-45 °C(lit.)
Boiling point	130 °C1 mm Hg(lit.)
Density	1.4921 (rough estimate)
refractive index	1.5500 (estimate)
Flash point	>230 °F
storage temp.	2-8°C
form	Crystalline Powder or Crystals
color	White to off-white
Water Solubility	Insoluble in water.
Sensitive	Lachrymatory
BRN	1938788
InChI	InChI=1S/C9H9BrO2/c1-12-9-5-3-2-4-7(9)8(11)6-10/h2-5H,6H2,1H3
InChIKey	GKNCPTLOPRDYMH-UHFFFAOYSA-N
SMILES	C(=O)(C1=CC=CC=C1OC)CBr
CAS DataBase Reference	31949-21-0(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363

PPE

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes

C,T

Risk Statements

Safety Statements

22-26-36/37/39-45

RIDADR

UN 3261 8/PG 2

WGK Germany

Hazard Note

Lachrymatory/Toxic/Keep Cold

HazardClass

PackingGroup

III

HS Code

29147000

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Skin Corr. 1B

NFPA 704

	1
3		0

2-BROMO-2'-METHOXYACETOPHENONE price More Price(45)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	100854	2-Bromo-2′-methoxyacetophenone 98%	31949-21-0	5g	$214	2026-04-30	Buy
Sigma-Aldrich	100854	2-Bromo-2′-methoxyacetophenone 98%	31949-21-0	1g	$73	2023-06-20	Buy
ChemScene	CS-W012983	2-Bromo-2'-methoxyacetophenone ≥96%	31949-21-0	5g	$16	2026-06-04	Buy
ChemScene	CS-W012983	2-Bromo-2'-methoxyacetophenone ≥96%	31949-21-0	10g	$21	2026-06-04	Buy
ChemScene	CS-W012983	2-Bromo-2'-methoxyacetophenone ≥96%	31949-21-0	25g	$46	2026-06-04	Buy

Product number	Packaging	Price	Buy
100854	5g	$214	Buy
100854	1g	$73	Buy
CS-W012983	5g	$16	Buy
CS-W012983	10g	$21	Buy
CS-W012983	25g	$46	Buy

2-BROMO-2'-METHOXYACETOPHENONE Chemical Properties,Uses,Production

Chemical Properties

White to greyish-green crystalline powder

Uses

2-Bromo-2'-methoxyacetophenone is used as a pharmaceutical intermediate .

Preparation

Also obtained according to the procedure of Buckman (80%).

Synthesis

579-74-8

31949-21-0

The general procedure for the synthesis of o-methoxy-2-bromoacetophenone from 2'-methoxyacetophenone was as follows: copper(II) bromide (2.97 g, 6.66 mmol) was added to a two-necked round-bottomed flask equipped with a reflux condenser. Ethyl acetate (10.0 mL) was added to the flask and the mixture was stirred at 70 °C for 5 min under nitrogen protection. A solution of chloroform (10.0 mL) of 1-(2-methoxyphenyl)ethanone (0.50 g, 3.33 mmol) was slowly added, followed by refluxing the reaction mixture for 8 hours. After completion of the reaction, it was cooled to room temperature, filtered through a diatomaceous earth pad and the filter cake was washed with ethyl acetate (20 mL). The filtrate was concentrated under reduced pressure and the crude product obtained was purified by column chromatography (eluent ratio ethyl acetate:hexane = 1:4) to afford the pure o-methoxy-2-bromoacetophenone (0.73 g, 96% yield) as a brown liquid. Thin layer chromatography Rf value was 0.43 (unfolding agent ratio ethyl acetate:hexane = 1:4); 1H NMR (300 MHz, CDCl3) δ: 7.81 (1H, dd, J = 7.8, 1.8 Hz), 7.52 (1H, td, J = 7.8, 1.8 Hz), 7.05-6.96 (2H, m), 4.61 (2H, s). 3.94 (3H, s); 13C NMR (75 MHz, CDCl3) δ: 192.3, 158.8, 134.9, 131.6, 124.9, 121.2, 111.7, 56.0, 38.0.

References

[1] Bulletin of the Korean Chemical Society, 2017, vol. 38, # 12, p. 1481 - 1485
[2] Tetrahedron Letters, 2006, vol. 47, # 27, p. 4707 - 4710
[3] Tetrahedron Letters, 2009, vol. 50, # 6, p. 700 - 703
[4] Chemistry - A European Journal, 2011, vol. 17, # 28, p. 7953 - 7959
[5] Molecules, 2017, vol. 22, # 5,

2-BROMO-2'-METHOXYACETOPHENONE synthesis

Synthesis of 2-BROMO-2'-METHOXYACETOPHENONE from 2'-Methoxyacetophenone

2-BROMO-2'-METHOXYACETOPHENONE Preparation Products And Raw materials

Raw materials

2-METHOXYACETOPHENONE 2'-Methoxyacetophenone Ethyl acetate Chloroform Cupric bromide

Preparation Products

Piperidine, 4-[4-(2-methoxyphenyl)-2-thiazolyl]-

2-BROMO-2'-METHOXYACETOPHENONE Suppliers

Global( 178)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Changzhou Huanling Chemical Co., Ltd.	89803005 18206112582	info@huanlingchem.com	China	983	68
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
Energy Chemical	61
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Changzhou Huanling Chemical Co., Ltd.	68
Jia Xing Isenchem Co.,Ltd	66
Nanjing Chemlin Chemical Co., Ltd	64

View Lastest Price from 2-BROMO-2'-METHOXYACETOPHENONE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-22	2-BROMO-2'-METHOXYACETOPHENONE 31949-21-0		1kg	98%	1000kgs	Shaanxi Dideu New Materials Co. Ltd
	2020-01-05	2-BROMO-2'-METHOXYACETOPHENONE 31949-21-0	$1.00	1KG	99%	200kg	Career Henan Chemical Co

2-BROMO-2'-METHOXYACETOPHENONE
31949-21-0
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

2-BROMO-2'-METHOXYACETOPHENONE
31949-21-0
$1.00
99%
Career Henan Chemical Co

2-BROMO-2'-METHOXYACETOPHENONE Spectrum

2-BROMO-2'-METHOXYACETOPHENONE(31949-21-0)¹HNMR 2-BROMO-2'-METHOXYACETOPHENONE(31949-21-0)FT-IR 2-BROMO-2'-METHOXYACETOPHENONE(31949-21-0)IR

31949-21-0(2-BROMO-2'-METHOXYACETOPHENONE)Related Search:

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JR-13728, 2-Bromo-1-(2-methoxyphenyl)ethanone, 98% 2-bromo-2-methoxy-1-phenylethanone O-METHOXYPHENACYL BROMIDE A-BROMO-O-METHOXYACETOPHENONE AKOS BBS-00003867 2-BROMO-2'-METHOXYACETOPHENONE 2'-METHOXYPHENACYL BROMIDE 2-METHOXYPHENACYL BROMIDE alpha-Bromo-o-methoxyacetophenone Ethanone, 2-bromo-1-(2-methoxyphenyl)- alpha-Bromo-2'-methoxyacetophenone alpha-Bromo-2-methoxyacetophenone bromomethyl 2-methoxyphenyl ketone 2-Methoxyphenacyl bromide 98% 2''-METHOXY-2-BROMOACETOPHENONE 2-BROMO-2''-METHOXYACETOPHENONE 98% α-Bromo-2'-methoxyacetophenone 1-(2-Methoxyphenyl)-2-bromoethanone 1-(Bromoacetyl)-2-methoxybenzene 2'-Methoxy-α-bromoacetophenone 2-Bromo-2'-methoxyacetophenone,98% 2-Bromo-1-(2-methoxyphenyl)ethan-1-one, 2-(Bromoacetyl)anisole, 2-Bromo-2'-methoxyacetophenone 2-Methoxyphenacylbromide97% 2-Bromo-2’-MethoxyAcetophenone 2-BROMO-1-(2-METHOXYPHENYL)ETHANONE 31949-21-0 C9 Carbonyl Compounds Building Blocks Organic Building Blocks Ketones