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2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one

2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one structure

CAS No.: 219138-24-6

Chemical Name:: 2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one

Synonyms: p38 MAPK Inhibitor;P38 MAP KINASE INHIBITOR;p-38 MAPK Inhibitor,p38 MAPK Inhibitor;p38 MAP Kinase Inhibitor, p38 MAPK inhibitor;2-(4-chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1H-pyrazol-3-one;2-(4-CHLOROPHENYL)-4-(FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE;2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one;2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-(pyridin-4-yl)-1,2-dihydro-3H-pyrazol-3-one;3H-Pyrazol-3-one, 2-(4-chlorophenyl)-4-(4-fluorophenyl)-1,2-dihydro-5-(4-pyridinyl)-

CBNumber:: CB6682024

Molecular Formula:: C20H13ClFN3O

Molecular Weight:: 365.79

MDL Number:: MFCD03452698

MOL File:: Mol file

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:54:21

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2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one Properties

Boiling point	534.1±60.0 °C(Predicted)
Density	1.388±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMF: 5 mg/ml; DMSO: 5 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 0.3 mg/ml
form	A crystalline solid
pka	6.61±0.10(Predicted)
color	Light yellow to yellow
InChI	1S/C20H13ClFN3O/c21-15-3-7-17(8-4-15)25-20(26)18(13-1-5-16(22)6-2-13)19(24-25)14-9-11-23-12-10-14/h1-12,24H
InChIKey	DZFBYHUKZSRPHU-UHFFFAOYSA-N
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

WGK Germany	WGK 1
Storage Class	11 - Combustible Solids

2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	17650	p38 MAPK Inhibitor ≥98%	219138-24-6	500μg	$134	2026-04-30	Buy
Cayman Chemical	17650	p38 MAPK Inhibitor ≥98%	219138-24-6	1mg	$253	2026-04-30	Buy
Cayman Chemical	17650	p38 MAPK Inhibitor ≥98%	219138-24-6	5mg	$795	2026-04-30	Buy
ChemScene	CS-0046093	p38 MAPK-IN-4 98.69%	219138-24-6	500??g	$74	2026-06-04	Buy
ChemScene	CS-0046093	p38 MAPK-IN-4 98.69%	219138-24-6	1mg	$119	2026-06-04	Buy

Product number	Packaging	Price	Buy
17650	500μg	$134	Buy
17650	1mg	$253	Buy
17650	5mg	$795	Buy
CS-0046093	500??g	$74	Buy
CS-0046093	1mg	$119	Buy

2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one Chemical Properties, Uses, Production

Uses

p38 MAPK-IN-4 (compound 6) is a p38 MAPK inhibitor with an 50 of 35 nM[1].

Biological Activity

Cell permeable: no', 'Product does not compete with ATP.', 'Reversible: no

IC 50

p38: 35 nM (IC₅₀)

References

[1] S E de Laszlo, et al. Pyrroles and other heterocycles as inhibitors of p38 kinase. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2689-94. DOI:10.1016/s0960-894x(98)00495-8

2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one Preparation Products And Raw materials

Raw materials

Preparation Products

2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one Suppliers

Global Suppliers ( 57)

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	9778	55
Shanghai Hongye Biotechnology Co. Ltd	400-9205774 400-920-5774	sales@glpbio.cn	China	6705	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Shanghai Zeye Biotechnology Co., Ltd.	021-57896695 13122526631	2885575445@qq.com	China	9777	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8137	58
Hefei Mokai Pharmaceutical Technology Co., Ltd	18130062233	690231469@qq.com	China	8000	58
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	59929	58
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24951	58

Supplier	Advantage
BOC Sciences	65
Shanghai YuanYe Biotechnology Co., Ltd.	60
Tianjin Kailiqi Biotechnology Co., Ltd.	55
Shanghai Hongye Biotechnology Co. Ltd	58
TargetMol Chemicals Inc.	58
Shanghai Zeye Biotechnology Co., Ltd.	58
MedBioPharmaceutical Technology Inc	58
Hefei Mokai Pharmaceutical Technology Co., Ltd	58
Bide Pharmatech Ltd.	58
TargetMol Chemicals Inc.	58

View Latest Price from 2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	p38 MAPK Inhibitor 219138-24-6	$88.00-483.00		99.96%	10g	TargetMol Chemicals Inc.
	2026-07-10	2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE 219138-24-6		1KG	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd

p38 MAPK Inhibitor
219138-24-6
$88.00-483.00
99.96%
TargetMol Chemicals Inc.

2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE
219138-24-6
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one Spectrum

2-(4-CHLOROPHENYL)-4-(4-FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE(219138-24-6)¹HNMR

219138-24-6 (2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one) Related Search:

EO 1428 p38 MAPK Monoclonal Antibody (Clone 9F12) Phenol,2,2'-sulfonylbis[3,4,6-trichloro]- p38 MAP Kinase Inhibitor III 2'-Fluoro-N-(4-hydroxyphenyl)-[1,1'-biphenyl]-4-butanamide

2-Propenoic acid, 3-[2,6-dichloro-4-[[[4-[3-(2,2-dimethyl-1-propoxypropyl)-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-, (2E)- P38 Mapk Inhibitor

1of2

2-(4-CHLOROPHENYL)-4-(FLUOROPHENYL)-5-PYRIDIN-4-YL-1,2-DIHYDROPYRAZOL-3-ONE P38 MAP KINASE INHIBITOR 2-(4-chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1H-pyrazol-3-one p38 MAPK Inhibitor p-38 MAPK Inhibitor,p38 MAPK Inhibitor 3H-Pyrazol-3-one, 2-(4-chlorophenyl)-4-(4-fluorophenyl)-1,2-dihydro-5-(4-pyridinyl)- 2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-(pyridin-4-yl)-1,2-dihydro-3H-pyrazol-3-one p38 MAP Kinase Inhibitor, p38 MAPK inhibitor 2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one 219138-24-6