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Kaempferol-3-O-rutinoside

Kaempferol-3-O-rutinoside Structure
Kaempferol-3-O-rutinoside structure
CAS No.
17650-84-9
Chemical Name:
Kaempferol-3-O-rutinoside
Synonyms
NICOTIFLORIN;Nictoflorin;KAEMPFEROL-3-RUTINOSIDE;Nicotiflorine;Aempferol-3-O-rutinoside;Kaempferol-3-O-rutinosid;Nicotifiorin;Nictoflorin (incorr;Nicotifloroside;Kaempferol-3-O-beta-rutinoside
CBNumber:
CB6690629
Molecular Formula:
C27H30O15
Molecular Weight:
594.52
MDL Number:
MFCD03427292
MOL File:
17650-84-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:54:21
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Kaempferol-3-O-rutinoside Properties

Melting point 200°C (dec.)
Boiling point 941.7±65.0 °C(Predicted)
Density 1.76
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka 6.20±0.40(Predicted)
color Off-White to Yellow
biological source plant (Clematis cultivar)
Stability Hygroscopic
Cosmetics Ingredients Functions ANTIOXIDANT
SKIN CONDITIONING - EMOLLIENT
SKIN PROTECTING
InChIKey RTATXGUCZHCSNG-FVJKAJKWNA-N
SMILES C1(O[C@H]2[C@H](O)[C@H]([C@H](O)[C@@H](CO[C@@H]3O[C@H]([C@H](O)[C@@H](O)[C@H]3O)C)O2)O)C(=O)C2=C(C=C(O)C=C2O)OC=1C1C=CC(O)=CC=1 |&1:2,3,5,6,8,11,13,14,16,18,r|
FDA UNII 4056D20K3H
UNSPSC Code 41116107
NACRES NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
Safety Statements  22-45-24/25
WGK Germany  3
HS Code  29389090
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

Kaempferol-3-O-rutinoside price More Price(52)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 90242 Kaempferol 3-O-β -rutinoside ≥98.0% (HPLC) 17650-84-9 1mg $163 2026-04-30 Buy
Sigma-Aldrich PHL80700 Kaempferol 3-rutinoside phyproof? Reference Substance 17650-84-9 10MG $524 2026-04-30 Buy
Sigma-Aldrich 90242 Kaempferol 3-O-β -rutinoside ≥98.0% (HPLC) 17650-84-9 5mg $593 2026-04-30 Buy
Cayman Chemical 27392 Nicotiflorin ≥98% 17650-84-9 1mg $69 2026-04-30 Buy
Cayman Chemical 27392 Nicotiflorin ≥98% 17650-84-9 5mg $263 2026-04-30 Buy
Product number Packaging Price Buy
90242 1mg $163 Buy
PHL80700 10MG $524 Buy
90242 5mg $593 Buy
27392 1mg $69 Buy
27392 5mg $263 Buy

Kaempferol-3-O-rutinoside Chemical Properties, Uses, Production

Description

Nicotiflorin is a flavonoid that has been found in I. glandulifera and has antioxidant and neuroprotective activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and ABTS radicals with EC50 values of 0.52 and 0.48 mg/ml, respectively, in cell-free assays. Nicotiflorin (1 μM) prevents hydrogen peroxide-induced decreases in tyrosine hydroxylase activity in PC12 cells and cell death in primary rat mesencephalic neurons. It decreases infarct volume by 24.5, 45.8, and 63.2% when administered at doses of 2.5, 5, and 10 mg/kg, respectively, in a rat model of cerebral ischemia-reperfusion injury induced by transient middle central artery occlusion (MCAO).

Chemical Properties

Light yellow needle-shaped crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Sophora japonica seeds and safflower.

Uses

Kaempferol 3-O-β -Rutinoside is a flavonoid antioxidant compound from Cichorium spinosum L. ecotype plants and also may display anti-diabetic activity. It is a component of many plant species including Helianthemum ruficomum.

Definition

ChEBI: Kaempferol-3-rutinoside is a kaempferol O-glucoside that is kaempferol attached to a rutinosyl [6-deoxy-alpha-L-mannosyl-(1->6)-beta-D-glucosyl] residue at position 3 via a glycosidic linkage. It has been isolated from the leaves of Solanum campaniforme. It has a role as a metabolite, a radical scavenger and a plant metabolite. It is a rutinoside, a trihydroxyflavone, a disaccharide derivative and a kaempferol O-glucoside.

General Description

Kaempferol 3-O-β -rutinoside is a bitter tasting flavonol glycoside that was isolated from flowers of a Clematis cultivar.

in vivo

At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the onset of ischemia markedly reduces brain infarct volume and neurological deficits[2]. Nicotiflorin (2.5-10 mg/kg) administered after onset of ischemia markedly reduces brain infarct volume by 24.5-63.2% and neurological deficits[3].

References

[1] KATARZYNA SZEWCZYK . Phenolic constituents of the aerial parts of Impatiens glandulifera Royle (Balsaminaceae) and their antioxidant activities[J]. Natural Product Research, 2019, 33 19: Pages 2851-2855. DOI: 10.1080/14786419.2018.1499644
[2] WEI QU . Kaempferol Derivatives Prevent Oxidative Stress–Induced Cell Death in a DJ-1–Dependent Manner[J]. Journal of pharmacological sciences, 2009, 110 2: Pages 191-200. DOI: 10.1254/jphs.09045fp
[3] RUNPING LI . Nicotiflorin reduces cerebral ischemic damage and upregulates endothelial nitric oxide synthase in primarily cultured rat cerebral blood vessel endothelial cells[J]. Journal of ethnopharmacology, 2006, 107 1: Pages 143-150. DOI: 10.1016/j.jep.2006.04.024

Kaempferol-3-O-rutinoside Preparation Products And Raw materials

Raw materials

Preparation Products

Kaempferol-3-O-rutinoside Suppliers

Global Suppliers ( 272)
Supplier Tel Email Country ProdList Advantage
ShangHai YuanYe Biotechnology Co., Ltd. 18916372613 shyysw007@163.com China 4993 60
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd 17701422015 3582572959@qq.com China 995 58
Chengdu RefMedic Biotech Co Ltd 028-82253651 18140204969 sales@refmedic.com China 2258 58
Hubei Danding Pharmaceutical Technology Co., Ltd 17701422019 17701422019 181646821@qq.com China 2421 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Sichuan Kulinan Technology Co., Ltd 400-1166-196 18981987031 cdhxsj@163.com China 11674 57
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
BioBioPha Co., Ltd. 0871-65217109 y.liu@mail.biobiopha.com China 5641 65
Chengdu Ai Keda Chemical Technology Co., Ltd. 4008-755-333 18080918076 800078821@qq.com China 9706 55
Supplier Advantage
ShangHai YuanYe Biotechnology Co., Ltd. 60
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd 58
Chengdu RefMedic Biotech Co Ltd 58
Hubei Danding Pharmaceutical Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61
Sichuan Kulinan Technology Co., Ltd 57
Dalian Meilun Biotech Co., Ltd. 58
BioBioPha Co., Ltd. 65
Chengdu Ai Keda Chemical Technology Co., Ltd. 55

View Latest Price from Kaempferol-3-O-rutinoside manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Kaempferol-3-O-rutinoside pictures 2023-02-24 Kaempferol-3-O-rutinoside
17650-84-9
 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
KAEMPFEROL-3-O-RUTINOSIDE pictures 2019-12-23 KAEMPFEROL-3-O-RUTINOSIDE
17650-84-9
 $1.00 100g 99% Career Henan Chemical Co

Kaempferol-3-O-rutinoside Spectrum

KAEMPFEROL-3-O-RUTINOSIDE(17650-84-9)1HNMR

17650-84-9 (Kaempferol-3-O-rutinoside) Related Search:

KaeMpferol 3-sophoroside-7-rhaMnoside Kaempferol 3-sophoroside-7-glucoside Kaempferol 3-(6-O-glucopyranosylglucoside) Kaempferol 3-neohesperidoside KAEMPFERITRIN
Sanggenon C kaempferol 3-O-sophoroside KaeMpferol-4'-O-β-D-glucopyranoside Kaempferol 7-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-3,5-dihydroxy-2-(4-hydroxyphenyl)-4H-benzopyran-4-one
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1of4

Nictoflorin (incorr 4H-1-Benzopyran-4-one,3-[[6-O-(6-deoxy-a-L-Mannopyranosyl)-b-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)- 3,4′,5,7-Tetrahydroxyflavone 3-rhamnoglucoside KaeMpferol-3-O-rutinosid, froM CarthaMus tinctorius Kaempfeol-3-O-rutinoside KAEMPFEROL-3-O-RUTINOSIDE WITH HPLC KAEMPFEROL-3-RUTINOSIDE hplc 3-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2-(4-hydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one 3-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one Kaempferol 3-rhamnoglucoside Nicotoflorin Kaempferol-3-O-rutinosid ,98% 3-[[6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one Nicotifiorin Kaempferol-3-O-rutinosid, 98%, from Carthamus tinctorius L. Kaempferol-3-O-rutinosid, ≥98.0%(HPLC) Rutoside Trihydrate Impurity 2（Rutoside Trihydrate EP Impurity B） Rutoside Trihydrate EP Impurity B Nicotiflorin (Kaempferol-3-O-beta-Rutinoside) Kaempferol-3-O-beta-rutinoside Rutoside EP Impurity B 4H-1-Benzopyran-4-one, 3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)- Kaempferol 3-O-β -Rutinoside (Nicotiflorin) Kaempferol 3-O-beta -Rutinoside (Nicotiflorin) Kaempferol 3-O-β -rutinoside 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one 5,7-Dihydroxy-2-(4-hydroxyphenyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one Kaempferol 3-rutinoside-RM Rutoside Trihydrate EP Impurity B (Kaempferol-3-O-Beta-Rutinoside) Kaempferol 3-O-b -Rutinoside (Nicotiflorin) Kaempferol 3-O-β -rutinoside Nicotiflorin (Kaempferol-3-O-rutinoside) Nicotiflorin (Standard) Aempferol-3-O-rutinoside KaeMpferol-3-O-rutinoside, Nicotiflorin Kaempferol-3-O-rutinosid KAEMPFEROL-3-RUTINOSIDE NICOTIFLORIN Nicotiflorine Nicotifloroside Nictoflorin Kaempferol-3-O-rutinoside 17650-84-9 Tetra-substituted Flavones chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract