3,5-BIS(METHYLSULFONYL)ANILINE
- CAS No.
- 101990-69-6
- Chemical Name:
- 3,5-BIS(METHYLSULFONYL)ANILINE
- Synonyms
- Dichloropyridine-4-methanol;3,5-BIS(METHYLSULFONYL)ANILINE;2,6-Dichloro-4-pyridinemethanol;3,5-BIS(METHYLSULPHONYL)ANILINE;2,6-DICHLOROPYRIDINE-4-METHANOL;4-Pyridinemethanol,2,6-dichloro-;(2,6-DICHLORO-4-PYRIDYL)METHANOL;2,6-DICHLORO-4-PYRIDINYL METHANOL;2,6-Dichloro-4-pyridinemethanol>(2,6-dichloropyridin- 4-yl)methanol
- CBNumber:
- CB6694531
- Molecular Formula:
- C6H5Cl2NO
- Molecular Weight:
- 178.02
- MDL Number:
- MFCD00052638
- MOL File:
- 101990-69-6.mol
- MSDS File:
- SDS
| Melting point | 0°C |
|---|---|
| Boiling point | 0°C |
| Density | 1.478±0.06 g/cm3(Predicted) |
| Flash point | 0°C |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 12.72±0.10(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C6H5Cl2NO/c7-5-1-4(3-10)2-6(8)9-5/h1-2,10H,3H2 |
| InChIKey | YDGJTFCKLFLWFM-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC(Cl)=CC(CO)=C1 |
| CAS DataBase Reference | 101990-69-6(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
3,5-BIS(METHYLSULFONYL)ANILINE price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | MNO000193 | (2,6-Dichloro-4-pyridyl)methanol | 101990-69-6 | 1g | $107 | 2025-07-31 | Buy |
| TCI Chemical | D4423 | 2,6-Dichloro-4-pyridinemethanol >98.0%(GC) | 101990-69-6 | 1g | $54 | 2025-07-31 | Buy |
| TCI Chemical | D4423 | 2,6-Dichloro-4-pyridinemethanol >98.0%(GC) | 101990-69-6 | 5g | $246 | 2025-07-31 | Buy |
| TRC | D436435 | 2,6-Dichloro-4-pyridinemethanol | 101990-69-6 | 5g | $370 | 2021-12-16 | Buy |
| Frontier Specialty Chemicals | JK183103 | 2,6-Dichloropyridine-4-methanol 98% | 101990-69-6 | 1g | $194 | 2021-12-16 | Buy |
3,5-BIS(METHYLSULFONYL)ANILINE Chemical Properties,Uses,Production
Chemical Properties
White powder
Uses
2,6-Dichloro-4-pyridinemethanol is a reagent in the preparation of functionalized compounds such as bipyridines and terpyridines via Stille-type cross coupling. Also used in the preparation of fluorescent chemosensors.
Definition
ChEBI: (2,6-Dichloro-4-pyridyl)methanol is a chloropyridine.
Synthesis
5398-44-7
101990-69-6
The general procedure for the synthesis of 2,6-dichloropyridine-4-methanol from 2,6-dichloroisonicotinic acid was as follows: Preparation of Intermediate 3.1: To a stirred solution of 2,6-dichloroisonicotinic acid (10.0 g, 52.1 mmol) in THF (300 mL) at 0 °C was slowly added sulfadimethane-borane (1:1) complex (16.0 g, 210.5 mmol) to the THF solution. The reaction mixture was stirred at room temperature overnight. Subsequently, MeOH (22 mL) was carefully added to the stirred mixture under cooling in an ice bath. The reaction mixture was diluted with ethyl acetate (300 mL) and washed sequentially with 1N aqueous sodium hydroxide solution (100 mL) and saturated aqueous sodium chloride solution. The organic layer was concentrated and the residue was purified by silica gel column chromatography (eluent ratio: hexane/ethyl acetate = 7:1 to 3:1) to afford the target product 2,6-dichloropyridine-4-methanol (8.3 g, 46.6 mmol). The product was characterized by 1H NMR (300 MHz, CDCl3, 300 K): δ = 7.25 (2H); 4.72 (2H); 2.24 (1H).
References
[1] Journal of the American Chemical Society, 2005, vol. 127, # 29, p. 10124 - 10125
[2] Chemical Communications, 1998, # 15, p. 1567 - 1568
[3] Organic Letters, 2010, vol. 12, # 5, p. 940 - 943
[4] Journal fuer Praktische Chemie (Leipzig), 1938, vol. <2> 151, p. 65,79
[5] Tetrahedron, 2007, vol. 63, # 2, p. 291 - 298
3,5-BIS(METHYLSULFONYL)ANILINE Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
View Lastest Price from 3,5-BIS(METHYLSULFONYL)ANILINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-09-03 | 3,5-BIS(METHYLSULFONYL)ANILINE
101990-69-6
|
US $1.10 / g | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2019-07-06 | 3,5-BIS(METHYLSULFONYL)ANILINE
101990-69-6
|
US $500.00 / KG | 1KG | 98% | 1ton | Career Henan Chemical Co |
-
- 3,5-BIS(METHYLSULFONYL)ANILINE
101990-69-6
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 3,5-BIS(METHYLSULFONYL)ANILINE
101990-69-6
- US $500.00 / KG
- 98%
- Career Henan Chemical Co
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