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3,5-Bis(methylsulfonyl)aniline

3,5-Bis(methylsulfonyl)aniline Structure
3,5-Bis(methylsulfonyl)aniline structure
CAS No.
101990-69-6
Chemical Name:
3,5-Bis(methylsulfonyl)aniline
Synonyms
Dichloropyridine-4-methanol;3,5-Bis(methylsulfonyl)aniline;2,6-Dichloro-4-pyridinemethanol;2,6-DICHLOROPYRIDINE-4-METHANOL;3,5-BIS(METHYLSULPHONYL)ANILINE;4-Pyridinemethanol,2,6-dichloro-;(2,6-DICHLORO-4-PYRIDYL)METHANOL;2,6-DICHLORO-4-PYRIDINYL METHANOL;2,6-Dichloro-4-pyridinemethanol>(2,6-dichloropyridin- 4-yl)methanol
CBNumber:
CB6694531
Molecular Formula:
C6H5Cl2NO
Molecular Weight:
178.02
MDL Number:
MFCD00052638
MOL File:
101990-69-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:54:21
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3,5-Bis(methylsulfonyl)aniline Properties

Melting point 0°C
Boiling point 0°C
Density 1.478±0.06 g/cm3(Predicted)
Flash point 0°C
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 12.72±0.10(Predicted)
color White to Off-White
InChI InChI=1S/C6H5Cl2NO/c7-5-1-4(3-10)2-6(8)9-5/h1-2,10H,3H2
InChIKey YDGJTFCKLFLWFM-UHFFFAOYSA-N
SMILES C1(Cl)=NC(Cl)=CC(CO)=C1
CAS DataBase Reference 101990-69-6(CAS DataBase Reference)
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  22-36/37/38
Safety Statements  26-36/37/39
WGK Germany  WGK 3
HazardClass  IRRITANT
HS Code  29333990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
NFPA 704
1
2 0

3,5-Bis(methylsulfonyl)aniline price More Price(64)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich MNO000193 (2,6-Dichloro-4-pyridyl)methanol 101990-69-6 1g $114 2026-04-30 Buy
TCI Chemical D4423 2,6-Dichloro-4-pyridinemethanol >98.0%(GC) 101990-69-6 1g $54 2026-04-30 Buy
TCI Chemical D4423 2,6-Dichloro-4-pyridinemethanol >98.0%(GC) 101990-69-6 5g $246 2026-04-30 Buy
TRC TRC-D436435-5G 2,6-Dichloro-4-pyridinemethanol 101990-69-6 5g $498 2026-06-03 Buy
TRC TRC-D436435-1G 2,6-Dichloro-4-pyridinemethanol 101990-69-6 1g $189 2026-06-03 Buy
Product number Packaging Price Buy
MNO000193 1g $114 Buy
D4423 1g $54 Buy
D4423 5g $246 Buy
TRC-D436435-5G 5g $498 Buy
TRC-D436435-1G 1g $189 Buy

3,5-Bis(methylsulfonyl)aniline Chemical Properties, Uses, Production

Chemical Properties

White powder

Uses

2,6-Dichloro-4-pyridinemethanol is a reagent in the preparation of functionalized compounds such as bipyridines and terpyridines via Stille-type cross coupling. Also used in the preparation of fluorescent chemosensors.

Definition

ChEBI: (2,6-Dichloro-4-pyridyl)methanol is a chloropyridine.

Synthesis

2,6-Dichloroisonicotinic acid

5398-44-7

3,5-BIS(METHYLSULFONYL)ANILINE

101990-69-6

The general procedure for the synthesis of 2,6-dichloropyridine-4-methanol from 2,6-dichloroisonicotinic acid was as follows: Preparation of Intermediate 3.1: To a stirred solution of 2,6-dichloroisonicotinic acid (10.0 g, 52.1 mmol) in THF (300 mL) at 0 °C was slowly added sulfadimethane-borane (1:1) complex (16.0 g, 210.5 mmol) to the THF solution. The reaction mixture was stirred at room temperature overnight. Subsequently, MeOH (22 mL) was carefully added to the stirred mixture under cooling in an ice bath. The reaction mixture was diluted with ethyl acetate (300 mL) and washed sequentially with 1N aqueous sodium hydroxide solution (100 mL) and saturated aqueous sodium chloride solution. The organic layer was concentrated and the residue was purified by silica gel column chromatography (eluent ratio: hexane/ethyl acetate = 7:1 to 3:1) to afford the target product 2,6-dichloropyridine-4-methanol (8.3 g, 46.6 mmol). The product was characterized by 1H NMR (300 MHz, CDCl3, 300 K): δ = 7.25 (2H); 4.72 (2H); 2.24 (1H).

References

[1] Journal of the American Chemical Society, 2005, vol. 127, # 29, p. 10124 - 10125
[2] Chemical Communications, 1998, # 15, p. 1567 - 1568
[3] Organic Letters, 2010, vol. 12, # 5, p. 940 - 943
[4] Journal fuer Praktische Chemie (Leipzig), 1938, vol. <2> 151, p. 65,79
[5] Tetrahedron, 2007, vol. 63, # 2, p. 291 - 298

3,5-Bis(methylsulfonyl)aniline synthesis

99-11-6
101990-69-6
Synthesis of 3,5-Bis(methylsulfonyl)aniline from Citrazinic acid

3,5-Bis(methylsulfonyl)aniline Preparation Products And Raw materials

Raw materials

Toluene 2,6-Dichloroisonicotinic acid Lithium Aluminum Hydride Methanol Thionyl chloride
2,6-Dichloroisonicotinamide Ethyl 2,6-dichloroisonicotinate 2,6-Dichloropyridine-4-methylamine 2,6-Dichloropyridine-4-carbonyl chloride 2,6-Dichloropyridine-4-carboxaldehyde
2,6-Dichloroisonicotinonitrile Methyl 2,6-dichloroisonicotinate Citrazinic acid

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Preparation Products

3,5-Bis(methylsulfonyl)aniline Suppliers

Global Suppliers ( 152)
Supplier Tel Email Country ProdList Advantage
Tianjin Wizard Science and Technology Co., Ltd. 22-22-58620773 18102163693 tjchemwizard@163.com China 94 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
ZEROSCHEM.CO.,LTD. 10-61256048 13810278579; sales@zeroschem.com China 1400 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Supplier Advantage
Tianjin Wizard Science and Technology Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
TCI (Shanghai) Development Co., Ltd. 81
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Pure Chemistry Scientific Inc. 62
Adamas Reagent, Ltd. 59
Accela ChemBio Co.,Ltd. 64
ZEROSCHEM.CO.,LTD. 59
Nanjing Chemlin Chemical Co., Ltd 64

View Latest Price from 3,5-Bis(methylsulfonyl)aniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3,5-BIS(METHYLSULFONYL)ANILINE pictures 2026-08-20 3,5-BIS(METHYLSULFONYL)ANILINE
101990-69-6
 $1.10 1g 99.00% 100 Tons min Dideu Industries Group Limited
3,5-BIS(METHYLSULFONYL)ANILINE pictures 2019-07-06 3,5-BIS(METHYLSULFONYL)ANILINE
101990-69-6
 $500.00 1KG 98% 1ton Career Henan Chemical Co

3,5-Bis(methylsulfonyl)aniline Spectrum

3,5-BIS(METHYLSULFONYL)ANILINE(101990-69-6)1HNMR3,5-BIS(METHYLSULFONYL)ANILINE(101990-69-6)FT-IR

101990-69-6 (3,5-Bis(methylsulfonyl)aniline) Related Search:

3,5-Bis(methylsulfonyl)aniline Methyl 2,6-dichloroisonicotinate 2,6-Dichloropyridine 2,3,5,6-Tetrachloropyridine-4-carboxylic acid 3,5-Dichlorobenzyl 2,6-dichloroisonicotinate
4-(Cyanomethyl)phenyl 2,6-dichloroisonicotinate (2,6-Dichloro-4-pyridyl)methyl 2,6-dichloroisonicotinate 2-Acetylphenyl 2,6-dichloroisonicotinate (2,6-Dichloro-4-pyridyl)methyl 4-(tert-butyl)benzoate 2-Chloro-4-fluorophenyl 2,6-dichloroisonicotinate
2-(2,6-Dichloro-4-pyridyl)-5-fluoro-4H-3,1-benzoxazin-4-one Ethyl 2-([([(2,6-dichloroisonicotinoyl)oxy]imino)(2,6-dichlorophenyl)methyl]amino)acetate O2-[(2,6-Dichloro-4-pyridyl)carbonyl]-5-nitrothiophene-2-carbohydroximamide (2,6-Dichloro-4-pyridyl)methyl thiophene-2-carboxylate N-[(2,6-Dichloroisonicotinoyl)oxy]-2-furamide
O4-[(2,6-Dichloro-4-pyridyl)carbonyl]-3-(2,6-dichlorophenyl)-5-methylisoxazole-4-carbohydroximamide 2-[(4-Chlorobenzyl)thio]-4-(([(2,6-dichloroisonicotinoyl)oxy]imino)methyl)pyrimidine (2,6-Dichloro-4-pyridyl)methyl N,N-dimethylcarbamate

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3,5-BIS(METHYLSULPHONYL)ANILINE 2,6-DICHLORO-4-PYRIDINYL METHANOL (2,6-DICHLORO-4-PYRIDYL)METHANOL 2,6-DICHLOROPYRIDINE-4-METHANOL 2,6-Dichloro-4-(hydroxymethyl)pyridine 2,6-Dichloropyridine-4-methanol ,98% (2,6-dichloropyridin- 4-yl)methanol 2,6-Dichloro-4-pyridinemethanol 4-Pyridinemethanol,2,6-dichloro- 2,6-Dichloro-4-(hydroxymethyl)pyridine 95+% 2,6-Dichloro-4-pyridinemethanol> 3,5-BIS(METHYLSULFONYL)ANILINE ISO 9001：2015 REACH Dichloropyridine-4-methanol 3,5-Bis(methylsulfonyl)aniline 101990-69-6 C8H11NO4S2 Heterocycle-Pyridine series