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Mosapride citrate

Mosapride citrate Structure
Mosapride citrate structure
CAS No.
112885-42-4
Chemical Name:
Mosapride citrate
Synonyms
as4370;Gasmotin;enzamidecitrate;AS-4370 citrate;TAK-370 citrate;MOSAPRIDE CITRATE;Mosapride citrate,>99%;Mosapride Citrate (TAK-370;Mosapride citrate USP/EP/BP;Mosapride citrate - Bio-X ?
CBNumber:
CB6696030
Molecular Formula:
C27H33ClFN3O10
Molecular Weight:
614.02
MDL Number:
MFCD00874415
MOL File:
112885-42-4.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:41
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Mosapride citrate Properties

Melting point 143-145°
storage temp. Inert atmosphere,2-8°C
solubility DMSO (Slightly), Ethanol (Slightly, Sonicated)
form Solid
color White to Off-White
Stability Hygroscopic
InChIKey HUZTYZBFZKRPFG-UHFFFAOYSA-N
SMILES C(O)(C(=O)O)(CC(=O)O)CC(=O)O.C(C1C=C(Cl)C(N)=CC=1OCC)(=O)NCC1OCCN(CC2C=CC(F)=CC=2)C1
CAS DataBase Reference 112885-42-4(CAS DataBase Reference)
FDA UNII MF497J489P

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P280-P305+P351+P338-P310
Toxicity LD50 in male, female mice, rats (mg/kg): >3000, >3000, >3000, 1905 orally; >1000, 914, >1000, >1000 i.p.; all species >1000 s.c.; in male, female dogs (mg/kg): both >400 orally (Yatera)
NFPA 704
0
3 0

Mosapride citrate price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 30048 Mosapride (citrate) 112885-42-4 10mg $57 2024-03-01 Buy
Cayman Chemical 30048 Mosapride (citrate) 112885-42-4 250mg $887 2024-03-01 Buy
Cayman Chemical 30048 Mosapride (citrate) 112885-42-4 50mg $208 2024-03-01 Buy
Cayman Chemical 30048 Mosapride (citrate) 112885-42-4 100mg $384 2024-03-01 Buy
Tocris 2844 Mosapridecitrate ≥99%(HPLC) 112885-42-4 50 $459 2021-12-16 Buy
Product number Packaging Price Buy
30048 10mg $57 Buy
30048 250mg $887 Buy
30048 50mg $208 Buy
30048 100mg $384 Buy
2844 50 $459 Buy

Mosapride citrate Chemical Properties,Uses,Production

Description

Mosapride is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69.9 nM). It is selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and α1- and α2-adrenergic receptors but acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM). It induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC50s = 208.4 and 73.2 nM, respectively). Mosapride (0.5 and 1 mg/kg, i.v.) increases antral and duodenal, but not ileal or colonic, motility in conscious dogs. It also increases gastric emptying in rats when administered at doses ranging from 0.03 to 30 mg/kg.

Uses

As a selective SR-4 activator and a SR-3 inhibitor, Mosapride(Mosapride citrate) is a gastroprokinetic agent that acts as a selective 5HT4 agonist which accelerates gastric emptying and is used for the treatment of acid reflux, irritable bowel syndrome and functional dyspepsia.

Uses

Mosapride Citrate is a selective SR-4 activator and a SR-3 inhibitor.

Biological Activity

5-HT 4 receptor agonist and 5-HT 3 receptor antagonist. Displays no activity at D 2 , α 1 , α 2 , 5-HT 1 and 5-HT 2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs.

Synthesis

Mosapride

112885-41-3

Mosapride citrate

112885-42-4

GENERAL STEPS: To a suspension of 1.3 g (2.5 mmol) of 4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide (Compound VIII) and 3 mL of water was added 12 mL of 117% aqueous hydrochloric acid. The resulting solution was stirred at 40°C for 3 hours, cooled to 10°C and 38 mL of 4M aqueous sodium hydroxide solution was added dropwise. The precipitated mosapride base (Compound IX) was filtered and washed twice with water to give 1.05 g (100%) of Compound IX.1.01 g of the above obtained Compound IX was warmed to boiling with 25 mL of 10% aqueous citric acid solution with stirring, cooled to 0°C, the precipitated product was filtered, and washed twice with water to give 1.34 g (86%) of 4-amino-5-chloro-2-ethanol oxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide 2-hydroxypropane-1,2,3-tricarboxylate. Melting point: 110-113°C.

storage

room temperature (desiccate)

References

[1] Patent: WO2003/106440, 2003, A2. Location in patent: Page 10

Mosapride citrate synthesis

112885-41-3
77-92-9
112885-42-4
Synthesis of Mosapride citrate from Mosapride and Citric acid

Mosapride citrate Preparation Products And Raw materials

Raw materials

Benzamide, 4-(acetylamino)-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]- Mosapride Citric acid

Preparation Products

Mosapride citrate Suppliers

Global( 314)Suppliers
Supplier Tel Email Country ProdList Advantage
Chongqing Ensky Pharmaceutical Co.,Ltd.
+86-23-86815286 +86-13983794297 sales@ensky-chemical.com China 92 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21620 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29852 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8615060885618 sales@amoychem.com China 6369 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Longyan Tianhua Biological Technology Co., Ltd 		0086 18039857276 18039857276 CHINA 2783 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30229 58
Supplier Advantage
Chongqing Ensky Pharmaceutical Co.,Ltd.
58
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Xiamen AmoyChem Co., Ltd 		58
Hubei xin bonus chemical co. LTD 		58
Standardpharm Co. Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
SIMAGCHEM CORP 		58
Longyan Tianhua Biological Technology Co., Ltd 		58
Career Henan Chemica Co 		58

View Lastest Price from Mosapride citrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Mosapride citrate pictures 2025-10-09 Mosapride citrate
112885-42-4
 US $0.00 / KG 1KG 98.0% 500kg/month WUHAN FORTUNA CHEMICAL CO., LTD
Mosapride citrate pictures 2025-04-04 Mosapride citrate
112885-42-4
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
Mosapride citrate pictures 2021-11-04 Mosapride citrate
112885-42-4
 US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd
  • Mosapride citrate pictures
  • Mosapride citrate
    112885-42-4
  • US $10.00 / Kg/Bag
  • 99%
  • Hebei Zhanyao Biotechnology Co. Ltd

Mosapride citrate Spectrum

Mosapride citrate(112885-42-4)1HNMR

112885-42-4(Mosapride citrate)Related Search:

Mosapride Mosapride Impurity 3 Mosapride Impurity 6 Mosapride Impurity 7 4-amino-5-chloro-2-ethoxy-N-((2-morpholinyl)methyl)benzamide
Mosapride Impurity 8 Mosapride Impurity 2 Mosapride Citric Amide Mosapride N-Oxide Des-4-fluorobenzyl Mosapride-d5
Mosapride Impurity 4 Mosapride Lactose Conjugate Mosapride Impurity 1 Morpholin-2-yl-methylamine 2-Methylmorpholine
Mosapride citrate 3-Hydroxyazetidine hydrochloride (4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE

1of4

4-AMINO-5-CHLORO-2-ETHOXY-N-[[4-(4-FLUOROBENZYL)-2-MORPHOLINYL]METHYL]BENZAMIDE CITRATE DIHYDRATE 4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-benzamide 2-hydroxy-1,2,3-propanetricarboxylate Gasmotin enzamidecitrate yl)methyl)-,2-hydroxy-1,2,3-propanetricarboxylate(1:1) 4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]benzamidecitrate 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide 4-azanyl-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide Benzamide, 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-, 2-hydroxy-1,2,3-propanetricarboxylate 4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide 2-hydroxypropane-1,2,3-tricarboxylate MOSAPRIDE CITRATE (+-)-4-amino-5-chloro-2-ethoxy-n-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)b as4370 benzamide,4-amino-5-chloro-2-ethoxy-n-((4-((4-fluorophenyl)methyl)-2-morpholin AS-4370 citrate TAK-370 citrate Mosapride citrate,>99% Mosapride citrate USP/EP/BP Mosapride Citrate DISCONTINUED PLEASE SEE M730995 Mosapride Citrate (TAK-370 Mosapride CitrateQ: What is Mosapride Citrate Q: What is the CAS Number of Mosapride Citrate Q: What is the storage condition of Mosapride Citrate Q: What are the applications of Mosapride Citrate Mosapridecitrate/TAK-370citrate/AS-4370citrate Mosapride Citrate, 10 mM in DMSO MOSAPRIDE CITRATE (NON-STERILE BULK FORM) Mosapride citrate - Bio-X ? 112885-42-4 C21H25ClFN3O3C6H8O7C C21H25ClFN3O3C6H8O72H20 C27H33ClFN3O10 C21H25ClFN3O3C6H8O72H2O C21H25ClFN3O3C6H8O7 C21H25ClFN3O3C6H8O7C27H33ClFN3O10 Inhibitors APIS API TAK-370, AS-4370, Gasmotin Gastroprokinetic Agent