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Mosapride citrate

Mosapride citrate Structure
Mosapride citrate structure
CAS No.
112885-42-4
Chemical Name:
Mosapride citrate
Synonyms
as4370;Gasmotin;enzamidecitrate;AS-4370 citrate;TAK-370 citrate;MOSAPRIDE CITRATE;Mosapride citrate,>99%;Mosapride Citrate (TAK-370;Mosapride citrate USP/EP/BP;Mosapride citrate - Bio-X ?
CBNumber:
CB6696030
Molecular Formula:
C27H33ClFN3O10
Molecular Weight:
614.02
MDL Number:
MFCD00874415
MOL File:
112885-42-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-19 07:28:27
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Mosapride citrate Properties

Melting point 143-145°
storage temp. Inert atmosphere,2-8°C
solubility DMSO (Slightly), Ethanol (Slightly, Sonicated)
form Solid
color White to Off-White
Stability Hygroscopic
InChIKey HUZTYZBFZKRPFG-UHFFFAOYSA-N
SMILES C(O)(C(=O)O)(CC(=O)O)CC(=O)O.C(C1C=C(Cl)C(N)=CC=1OCC)(=O)NCC1OCCN(CC2C=CC(F)=CC=2)C1
CAS DataBase Reference 112885-42-4(CAS DataBase Reference)
FDA UNII MF497J489P

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P280-P305+P351+P338-P310
Toxicity LD50 in male, female mice, rats (mg/kg): >3000, >3000, >3000, 1905 orally; >1000, 914, >1000, >1000 i.p.; all species >1000 s.c.; in male, female dogs (mg/kg): both >400 orally (Yatera)
NFPA 704
0
3 0

Mosapride citrate price More Price(72)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 30048 Mosapride (citrate) ≥98% 112885-42-4 10mg $63 2026-04-30 Buy
Cayman Chemical 30048 Mosapride (citrate) ≥98% 112885-42-4 50mg $229 2026-04-30 Buy
Cayman Chemical 30048 Mosapride (citrate) ≥98% 112885-42-4 100mg $423 2026-04-30 Buy
Cayman Chemical 30048 Mosapride (citrate) ≥98% 112885-42-4 250mg $976 2026-04-30 Buy
Usbiological 283141 Mosapride citrate Asreported 112885-42-4 25g $396 2026-06-03 Buy
Product number Packaging Price Buy
30048 10mg $63 Buy
30048 50mg $229 Buy
30048 100mg $423 Buy
30048 250mg $976 Buy
283141 25g $396 Buy

Mosapride citrate Chemical Properties, Uses, Production

Description

Mosapride is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69.9 nM). It is selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and α1- and α2-adrenergic receptors but acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM). It induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC50s = 208.4 and 73.2 nM, respectively). Mosapride (0.5 and 1 mg/kg, i.v.) increases antral and duodenal, but not ileal or colonic, motility in conscious dogs. It also increases gastric emptying in rats when administered at doses ranging from 0.03 to 30 mg/kg.

Uses

As a selective SR-4 activator and a SR-3 inhibitor, Mosapride(Mosapride citrate) is a gastroprokinetic agent that acts as a selective 5HT4 agonist which accelerates gastric emptying and is used for the treatment of acid reflux, irritable bowel syndrome and functional dyspepsia.

Uses

Mosapride Citrate is a selective SR-4 activator and a SR-3 inhibitor.

Biological Activity

5-HT 4 receptor agonist and 5-HT 3 receptor antagonist. Displays no activity at D 2 , α 1 , α 2 , 5-HT 1 and 5-HT 2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs.

Synthesis

Mosapride

112885-41-3

Mosapride citrate

112885-42-4

GENERAL STEPS: To a suspension of 1.3 g (2.5 mmol) of 4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide (Compound VIII) and 3 mL of water was added 12 mL of 117% aqueous hydrochloric acid. The resulting solution was stirred at 40°C for 3 hours, cooled to 10°C and 38 mL of 4M aqueous sodium hydroxide solution was added dropwise. The precipitated mosapride base (Compound IX) was filtered and washed twice with water to give 1.05 g (100%) of Compound IX.1.01 g of the above obtained Compound IX was warmed to boiling with 25 mL of 10% aqueous citric acid solution with stirring, cooled to 0°C, the precipitated product was filtered, and washed twice with water to give 1.34 g (86%) of 4-amino-5-chloro-2-ethanol oxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide 2-hydroxypropane-1,2,3-tricarboxylate. Melting point: 110-113°C.

storage

room temperature (desiccate)

References

[1] Patent: WO2003/106440, 2003, A2. Location in patent: Page 10

Mosapride citrate synthesis

112885-41-3
77-92-9
112885-42-4
Synthesis of Mosapride citrate from Mosapride and Citric acid

Mosapride citrate Preparation Products And Raw materials

Raw materials

Benzamide, 4-(acetylamino)-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]- Mosapride Citric acid

Preparation Products

Mosapride citrate Suppliers

Global Suppliers ( 315)
Supplier Tel Email Country ProdList Advantage
Hangzhou Xiao Bei Medical Technology Co., LTD +86-571-8526 3177 13962438025 beixi.dong@heryipharma.com China 196 58
Chengdu Saint - Kay Biotechnology Co., Ltd. 028-85157043 15882256948 676046971@qq.com China 4183 58
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
XiaoGan ShenYuan ChemPharm co,ltd 15527621225; 15527621225 1791901229@qq.com China 6742 52
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Wuhan Fortuna Chemical Co., Ltd 027-59207852 13308628970 buy@fortunachem.com China 2690 58
AILY INTL CHEMICAL CORP LTD 025-83208295 18913388297 ben@ailychem.com China 132 50
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
Supplier Advantage
Hangzhou Xiao Bei Medical Technology Co., LTD 58
Chengdu Saint - Kay Biotechnology Co., Ltd. 58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Adamas Reagent, Ltd. 59
XiaoGan ShenYuan ChemPharm co,ltd 52
BOC Sciences 65
Wuhan Fortuna Chemical Co., Ltd 58
AILY INTL CHEMICAL CORP LTD 50
Shanghai T&W Pharmaceutical Co., Ltd. 58
Haoyuan Chemexpress Co., Ltd. 61

View Latest Price from Mosapride citrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Mosapride citrate pictures 2026-09-16 Mosapride citrate
112885-42-4
 1KG 99.9% 500kg/month WUHAN FORTUNA CHEMICAL CO., LTD
Mosapride citrate pictures 2026-06-30 Mosapride citrate
112885-42-4
 1kg 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
Mosapride citrate pictures 2026-06-30 Mosapride citrate
112885-42-4
 1kg 98% 10000kgS Shaanxi Dideu New Materials Co. Ltd

Mosapride citrate Spectrum

Mosapride citrate(112885-42-4)1HNMR

112885-42-4 (Mosapride citrate) Related Search:

Mosapride Mosapride Impurity 7 Mosapride Impurity 6 Mosapride Impurity 3 4-amino-5-chloro-2-ethoxy-N-((2-morpholinyl)methyl)benzamide
Mosapride Impurity 8 Mosapride Impurity 2 Mosapride Citric Amide Mosapride N-Oxide Des-4-fluorobenzyl Mosapride-d5
Mosapride Impurity 4 Mosapride Lactose Conjugate Mosapride Impurity 1 MOSAPRIDE CITRATE DIHYDRATE 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine
Morpholin-2-yl-methylamine 2-Methylmorpholine Mosapride citrate

1of4

4-AMINO-5-CHLORO-2-ETHOXY-N-[[4-(4-FLUOROBENZYL)-2-MORPHOLINYL]METHYL]BENZAMIDE CITRATE DIHYDRATE 4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-benzamide 2-hydroxy-1,2,3-propanetricarboxylate Gasmotin enzamidecitrate yl)methyl)-,2-hydroxy-1,2,3-propanetricarboxylate(1:1) 4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]benzamidecitrate 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide 4-azanyl-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide Benzamide, 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-, 2-hydroxy-1,2,3-propanetricarboxylate 4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide 2-hydroxypropane-1,2,3-tricarboxylate MOSAPRIDE CITRATE (+-)-4-amino-5-chloro-2-ethoxy-n-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)b as4370 benzamide,4-amino-5-chloro-2-ethoxy-n-((4-((4-fluorophenyl)methyl)-2-morpholin AS-4370 citrate TAK-370 citrate Mosapride citrate,>99% Mosapride citrate USP/EP/BP Mosapride Citrate DISCONTINUED PLEASE SEE M730995 Mosapride Citrate (TAK-370 Mosapride CitrateQ: What is Mosapride Citrate Q: What is the CAS Number of Mosapride Citrate Q: What is the storage condition of Mosapride Citrate Q: What are the applications of Mosapride Citrate Mosapridecitrate/TAK-370citrate/AS-4370citrate Mosapride Citrate, 10 mM in DMSO MOSAPRIDE CITRATE (NON-STERILE BULK FORM) Mosapride citrate - Bio-X ? 112885-42-4 C21H25ClFN3O3C6H8O7C C21H25ClFN3O3C6H8O72H20 C27H33ClFN3O10 C21H25ClFN3O3C6H8O72H2O C21H25ClFN3O3C6H8O7 C21H25ClFN3O3C6H8O7C27H33ClFN3O10 Inhibitors APIS API TAK-370, AS-4370, Gasmotin Gastroprokinetic Agent